The first air-stable and efficient nucleophilic trialkylphosphine organocatalyst for the Baylis-Hillman reaction

Advanced Synthesis and Catalysis

Volumn 348, Issue 4-5, 2006, Pages 413-417

  He, Zhengrong ^a,b   Tang, Xiaofang ^a   Chen, Yaoming ^b   He, Zhengjie ^a  

^a NANKAI UNIVERSITY   (China)

^b CHENGDU INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

Activated alkenes; Aldehydes; Baylis Hillman reaction; Nucleophilic organocatalyst; Trialkylphosphine

Indexed keywords

EID: 33645906242     PISSN: 16154150     EISSN: 15213897     Source Type: Journal    
DOI: 10.1002/adsc.200505403     Document Type: Article

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32. Reactions were run as follows: at room temperature, a mixture of 4-nitrobenzaldehyde (1.0 mmol) and the catalyst (0.2 mmol) in ethyl acrylate (2.0 mL) was stirred for 6 h. After removal of volatile components on a rotary evaporator, the residue was subjected to silica gel column chromatography (petroleum ether-ethyl acetate, 6:1, v/v) to afford the product. The average yields for HMT and PTA were 8% and 86%, respectively, for 3 runs.