3-[2-[4-(3-Chloro-2-methylphenylmethyl)-1-piperazinyl]ethyl]-5,6-dimethoxy- 1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) is neuroprotective in rat microsphere embolism: Role of the cross-talk between calpain and caspase-3 through calpastatin

Journal of Pharmacology and Experimental Therapeutics

Volumn 317, Issue 2, 2006, Pages 529-536

  Han, Feng ^a   Shirasaki, Yasufumi ^b   Fukunaga, Kohji ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 [4 (3 CHLORO 2 METHYLPHENYLMETHYL) 1 PIPERAZINYL]ETHY] 5,6 DIMETHOXY 1 (4 IMIDAZOLYLMETHYL) 1H INDOLE; CALPAIN; CALPASTATIN; CASPASE 3; DY 9760E; FODRIN; MICROSPHERE; NEUROPROTECTIVE AGENT; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE (CALCIUM,CALMODULIN); UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN EMBOLISM; BRAIN ISCHEMIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME DEGRADATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME SUBSTRATE; ENZYMOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; BRAIN ISCHEMIA; CALCIUM-BINDING PROTEINS; CALMODULIN; CALPAIN; CASPASE 3; CASPASES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; INDAZOLES; INTRACRANIAL EMBOLISM; MALE; MICROSPHERES; NEURONS; NEUROPROTECTIVE AGENTS; PROTEIN BINDING; RATS; RATS, WISTAR;

EID: 33645889361     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.095018     Document Type: Article

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