Clozapine modulates aromatic L-amino acid decarboxylase activity in mouse striatum

Journal of Pharmacology and Experimental Therapeutics

Volumn 317, Issue 2, 2006, Pages 480-487

  Neff, Norton H ^a   Wemlinger, Trina A ^a   Duchemin, Anne Marie ^a   Hadjiconstantinou, Maria ^a  

^a THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; AROMATIC LEVO AMINO ACID DECARBOXYLASE; BIOLOGICAL MARKER; CATECHOLAMINE; CLOZAPINE; DOPAMINE; DOPAMINE 4 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; INDOLEAMINE; LEVODOPA; MESSENGER RNA; MUSCARINIC RECEPTOR BLOCKING AGENT; PROTEIN; SEROTONIN 1A ANTAGONIST; SEROTONIN 2C ANTAGONIST; SEROTONIN 3 ANTAGONIST; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; CATECHOLAMINE SYNTHESIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORPUS STRIATUM; DECARBOXYLATION; DOPAMINE METABOLISM; DOPAMINERGIC SYSTEM; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME LOCALIZATION; LOCUS CERULEUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN METABOLISM; RAPHE NUCLEUS; SINGLE DRUG DOSE; SUBSTANTIA NIGRA; TIME; VENTRAL TEGMENTUM;

ANIMALS; ANTIPSYCHOTIC AGENTS; AROMATIC-L-AMINO-ACID DECARBOXYLASES; CLOZAPINE; CORPUS STRIATUM; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE; MICE, INBRED STRAINS; MPTP POISONING; RECEPTORS, DOPAMINE; RECEPTORS, SEROTONIN;

EID: 33645855880     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.097972     Document Type: Article

References (40)

1. Berry MD, Juorio AV, Li XM, and Boulton AA (1996) Aromatic L-amino acid decarboxylase: a neglected and misunderstood enzyme. Neurochem Res 21:1075-1087.
2. Broderick PA and Piercey (1998) Clozapine, haloperidol and the D4 antagonist PNU-101387G: in vivo effects on mesocortical, mesolimbic and nigrostriatal dopamine and serotonin release. J Neural Transm 105:749-767.
3. Burki HR, Ruch W, and Asper H (1975) Effects of clozapine, thioridazine, perlapine and haloperidol on the metabolism of the biogenic amines in the brain of the rat. Psychopharmacologia 41:27-33.
4. Cho S, Duchemin A-M, Neff NH, and Hadjiconstantinou M (1999) Tyrosine hydroxylase, aromatic L-amino acid decarboxylase and dopamine metabolism after chronic treatment with dopaminergic drugs. Brain Res 830:237-245.
5. Cho S, Neff NH, and Hadjiconstantinou M (1997) Regulation of tyrosine hydroxylase and aromatic L-amino acid decarboxylase by dopaminergic drugs. Eur J Pharmacol 323:149-157.
6. Cumming P, Ase A, Laliberte C, Kuwabara H, and Gjedde A (1997) In vivo regulation of DOPA decarboxylase by dopamine receptors in rat brain. J Cereb Blood Flow Metab 17:1254-1260.
7. Durif F (1999) Treating and preventing levodopa-induced dyskinesias. Drugs Aging 14:337-345.
8. Eaton MJ, Gudehithlu KP, Quach T, Silvia CP, Hadjiconstantinou M, and Neff NH (1993) Distribution of aromatic L-amino acid decarboxylase mRNA in mouse brain by in situ hybridization histology. J Comp Neurol 336:1-15.
9. Fisher A, Biggs CS, Eradini O, and Starr MS (2000) Dual effects of L-3,4,-dihydroxyphenylalanine on aromatic L-amino acid decarboxylase, dopamine release and motor stimulation in the reserpine-treated rat: evidence that behaviour is dopamine independent. Neuroscience 95:97-111.
10. Fisher A, Biggs CS, and Starr MS (1998) Differential effects of NMDA and non-NMDA on the activity of aromatic L-amino acid decarboxylase activity in the nigrostriatal dopamine pathway of the rat. Brain Res 792:126-132.
11. Friedman JH and Factor SA (2000) Atypical antipsychotics in the treatment of drug-induced psychosis in Parkinson's disease. Movement Disorders 15:201-211.
12. Hadjiconstantinou M, Rossetti ZL, Silvia C, Krajnc D, and Neff NH (1988) Aromatic L-amino acid decarboxylase activity of the rat retina is modulated in vivo by environmental light. J Neurochem 51:1560-1564.
13. Hadjiconstantinou M, Rossetti ZL, Wemlinger TA, and Neff NH (1995) Dizocilpine enhances striatal tyrosine hydroxylase and aromatic L-amino acid decarboxylase activity. Eur J Pharmacol 289:97-101.
14. Hadjiconstantinou M, Wemlinger TA, Sylvia CP, Hubble JP, and Neff NH (1993) Aromatic L-amino acid decarboxylase activity of mouse striatum is modulated via dopamine receptors. J Neurochem 60:2175-2180.
15. Hefti F, Melamed E, and Wurtman RJ (1980) The decarboxylation of L-DOPA in parkinsonian brain: in vivo studies on an animal model. J Neural Transm 16 (Suppl):95-101.
16. Hefti F, Melamed E, and Wurtman RJ (1981) The site of dopamine formation in rat striatum after L-DOPA administration. J Pharmacol Exp Ther 217:189-197.
17. Hetey L, Kudrin VS, Shemanow AY, Rayevsky KS, and Oelssner W (1985) Presynaptic dopamine and serotonin receptors modulating tyrosine hydroxylase activity in synaptosomes of the nucleus accumbens of rats. Eur J Pharmacol 113:1-10.
18. Invernizzi R, Morali F, Pozzi L, and Samanin R (1990) Effects of acute and chronic clozapine on dopamine release and metabolism in the striatum and nucleus accumbens of conscious rats. Br J Pharmacol 100:774-778.
19. Kaakkola S and Wurtman RJ (1993) Effects of catechol-O-methyltransferase inhibitors and L-3,4-dihydroxyphenylalanine with or without carbidopa on extracellular dopamine in rat striatum. J Neurochem 60:137-144.
20. Kang UJ, Park DH, Wessel T, Baker H, and Joh TH (1992) DOPA-decarboxylation in the striata of rats with unilateral substantia nigra lesions. Neurosci Lett 147:53-57.
21. Kapur S and Remington G (2001) Atypical antipsychotics: New directions and new challenges in the treatment of schizophrenia. Annu Rev Med 52:503-517.
22. Karoum F and Egan MF (1992) Dopamine release and metabolism in the rat frontal cortex, nucleus accumbens and striatum: a comparison of acute clozapine and haloperidol. Br J Pharmacol 105:703-707.
23. Mao L, Lau YS, Petroske E, and Wang JQ (2001) Profound astrogenesis in the striatum of adult mice following nigrostriatal dopaminergic lesion by repeated MPTP administration. Dev Brain Res 131:57-65.
24. McMillen BA and Shore PA (1978) Comparative effects of clozapine and alphaadrenoceptor blocking drugs on regional noradrenaline metabolism in rat brain. Eur J Pharmacol 52:225-230.
25. Melamed E (1990) Interactions of exogenous L-dopa with nigrostriatal dopaminergic neurons in Parkinson's disease, in Parkinson's Disease: Anatomy, Pathology and Therapy (Streifer MB, Korczyn AD, Melamed E, and Youdim MBH eds) pp 61-66, Raven Press, New York.
26. Melamed E, Hefti F, Pettibone DJ, Liebman J, and Wurtman RJ (1981) Aromatic L-amino acid decarboxylase in rat corpus striatum: implications for action of L-dopa in parkinsonism. Neurology 31:651-655.
27. Meltzer HY, Li Z, Kaneda Y, and Ichikawa J (2003) Serotonin receptors: their key role in drugs to treat schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 27:1159-1172.
28. 11C]dopa. Brain Res 578:122-128.
29. Mura A, Jackson D, Manley MS, Young SJ, and Groves PM (1995) Aromatic L-amino acid decarboxylase immunoreactive cells in the striatum: a possible site for the conversion of exogenous L-DOPA to dopamine. Brain Res 704:51-60.
30. Neff NH, Wemlinger TA, and Hadjiconstantinou M (2000) SCH 23390 enhances exogenous L-DOPA decarboxylation in nigrostriatal neurons. J Neural Transm 107:429-443.
31. Nguyen TB and Angers M (1987) Effects of different monoamine oxidase inhibitors on the metabolism of L-DOPA in the rat brain. Biochem Pharmacol 36:1731-1735.
32. Onali P, Mosca E, and Olianas MC (1992) Presynaptic dopamine autoreceptors and second messengers controlling tyrosine hydroxylase activity in rat striatum. Neurochem Int 20 (Suppl):89S-93S.
33. 2-adrenoceptors. J Neurochem 52:647-652.
34. Rossetti ZL, Silvia CP, Krajnc D, Neff NH, and HadjiconstantinouM(1990) Aromatic L-amino acid decarboxylase is modulated by D1 dopamine receptors in rat retina. J Neurochem 54:787-791.
35. Rozas G, Liste I, Guerra MJ, and Labandeira-Garcia JL (1998) Sprouting of serotonergic afferents into striatum after selective lesion of the dopaminergic system by MPTP in adult mice. Neurosci Lett 245:151-154.
36. Tarsy D, Baldessarini RJ, and Tarazi FI (2002) Effects of newer antipsychotics on extrapyramidal function. CNS Drugs 16:23-45.
37. Weihmuller FB, Bruno JP, Neff NH, and Hadjiconstantinou M (1990) Dopamine receptor plasticity following MPTP-induced nigrostriatal lesions in the mouse. Eur J Pharmacol 180:369-372.
38. Young EA, Duchemin A-M, Neff NH, and Hadjiconstantinou M (1998) Parallel modulation of striatal dopamine synthetic enzymes by second messenger pathways. Eur J Pharmacol 357:15-23.
39. Zhu MY, Juorio AV, Paterson IA, and Boulton AA (1992) Regulation of aromatic L-amino acid decarboxylase by dopamine receptors in the rat brain. J Neurochem 58:637-641.
40. Zivkovic B, Guidotti A, Revuelta A, and Costa E (1975) Effect of thioridazine, clozapine and other antipsychotics on the kinetic state of tyrosine hydroxylase and on the turnover rate of dopamine in striatum and nucleus accumbens. J Pharmacol Exp Ther 194:37-46.