Therapeutic strategies for treating hair loss

Drug Discovery Today: Therapeutic Strategies

Volumn 3, Issue 1, 2006, Pages 101-110

  Paus, Ralf ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA LACTALBUMIN; AMMONIUM TRICHLORO(DIOXYETHYLENE O,O')TELLURATE; ANTIANDROGEN; ANTICOAGULANT AGENT; ANTITHYROID AGENT; ASIASARI EXTRACT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BIMATOPROST; CYCLOSPORIN A; CYPROTERONE ACETATE; DIAZOXIDE; ESTRADIOL; FINASTERIDE; LATANOPROST; MELATONIN; MINOXIDIL; PARATHYROID HORMONE; PEPTIDE HORMONE ANTAGONIST; PLANT EXTRACT; POLYPHENOL DERIVATIVE; PROCYANIDIN DERIVATIVE; PROTEIN KINASE C INHIBITOR; RETINOID; RU 58841 MYRISTATE; SOYBEAN PROTEIN; SYNTAXIN 2; TELLURIUM; THYMOSIN BETA4; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZINC;

ASIASARI; CELL GROWTH; CELL TRANSFORMATION; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG RESEARCH; DRUG TARGETING; HAIR FOLLICLE; HAIR GROWTH; HAIR LOSS; HUMAN; MEDICINAL PLANT; MOLECULAR MECHANICS; NONHUMAN; REVIEW; SOYBEAN; TENSILE STRENGTH;

EID: 33645855867     PISSN: 17406773     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddstr.2006.03.004     Document Type: Review

References (115)

1. Bandaranayake I., and Mirmirani P. Hair loss remedies - separating fact from fiction. Cutis 73 (2004) 107-114
2. Price V.H. Treatment of hair loss. N. Engl. J. Med. 341 (1999) 964-973
3. Hadshiew I., et al. Burden of hair loss: stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia. J. Invest. Dermatol. 123 (2004) 455-457
4. Hunt N., and McHale S. The psychological impact of alopecia. BMJ 331 (2005) 951-953
5. Ross E.K., and Shapiro J. Management of hair loss. Dermatol. Clin. 23 (2005) 227-243
6. In: Dawber R. (Ed). Diseases of the Hair and Scalp (1997), Blackwell
7. Pierard G.E., et al. EEMCO guidance for the assessment of hair shedding and alopecia. Skin Pharmacol. Physiol. 17 (2004) 98-110
8. Olsen E.A., et al. Evaluation and treatment of male and female pattern hair loss. J. Am. Acad. Dermatol. 52 (2005) 301-311
9. Paus R., and Cotsarelis G. The biology of hair follicles. N. Engl. J. Med. 341 (1990) 491-497
10. Stenn K., and Paus R. Controls of hair follicle cycling. Physiol. Rev. 81 (2001) 449-494
11. Alonso L., and Fuchs E. The hair cycle. J. Cell Sci. 119 Pt 3 (2006) 391-393
12. Paus R., and Foitzik K. In search of the hair cycle clock: a guided tour. Differentiation 72 (2004) 489-511
13. Ito T., et al. Collapse and restoration of MHC class I-dependent immune privilege: exploiting the human hair follicle as a model. Am. J. Pathol. 164 (2004) 623-634
14. Paus R., et al. A "hairy" privilege. Trends Immunol. 26 (2005) 32-40
15. Lindner G., et al. Analysis of apoptosis during hair follicle regression (catagen). Am. J. Pathol. 151 (1997) 1601-1617
16. Botchkareva N.V., et al. Apoptosis in the hair follicle. J. Invest. Dermatol. 126 (2006) 258-264
17. Kaufman K.D., et al. Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group. J. Am. Acad. Dermatol. 39 (1998) 578-589
18. Messenger A.G., and Rundegren J. Minoxidil: mechanisms of action on hair growth. Br. J. Dermatol. 150 (2004) 186-194
19. Paus R., et al. Hair growth control by immunosuppression. Arch. Dermatol. Res. 288 (1996) 408-410
20. Maurer M., et al. Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia. Am. J. Pathol. 150 (1997) 1433-1441
21. Thornton M.J. Oestrogen functions in skin and skin appendages. Expert Opin. Ther. Targets 9 (2005) 617-629
22. Conrad F., et al. Estrogens and human scalp hair growth - still more questions than answers. J. Invest. Dermatol. 122 (2004) 840-842
23. Conrad F., et al. Substantial sex-dependent differences in the response of human scalp hair follicles to estrogen stimulation in vitro advocate gender-tailored management of female versus male pattern balding. J. Investig. Dermatol. Symp. Proc. 10 (2005) 243-246
24. Libecco J.F., and Bergfeld W.F. Finasteride in the treatment of alopecia. Expert Opin. Pharmacother. 5 (2004) 933-940
25. Arca E., et al. An open, randomized, comparative study of oral finasteride and 5% topical minoxidil in male androgenetic alopecia. Dermatology 209 (2004) 117-125
26. Lucky A.W., et al. A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss. J. Am. Acad. Dermatol. 50 (2004) 541-553
27. Berger R.S., et al. The effects of minoxidil, 1% pyrithione zinc and a combination of both on hair density: a randomized controlled trial. Br. J. Dermatol. 149 (2003) 354-362
28. Kawashima M., et al. Finasteride in the treatment of Japanese men with male pattern hair loss. Eur. J. Dermatol. 14 (2004) 247-254
29. Leavitt M., et al. Effects of finasteride (1 mg) on hair transplant. Dermatol. Surg. 31 (2005) 1268-1276
30. Trueb R.M., and Swiss Trichology Study Group. Finasteride treatment of patterned hair loss in normoandrogenic postmenopausal women. Dermatology 209 (2004) 202-207
31. Valsecchi R., et al. Female androgenetic alopecia treated by finasteride: a case forward. Acta Derm. Venereol. 84 (2004) 488-489
32. Rapaport M.J. Follow-up of 1 mg finasteride treatment of male pattern baldness-difference between clinical trials and private office follow-up: influences on prescribing habits evaluated. Dermatol. Surg. 30 (2004) 761-763
33. Davies G.C., et al. Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles. J. Invest. Dermatol. 124 (2005) 686-694
34. Salem O.I., et al. Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J. Med. Chem. 49 (2006) 748-759
35. Bratoeff E., et al. Recent advances in the chemistry and pharmacological activity of new steroidal antiandrogens and 5 alpha-reductase inhibitors. Curr. Med. Chem. 12 (2005) 927-943
36. Olszewska M., and Rudnicka L. Effective treatment of female androgenic alopecia with dutasteride. J. Drugs Dermatol. 4 (2005) 637-640
37. Azziz R., et al. Androgen excess in women: experience with over 1000 consecutive patients. J. Clin. Endocrinol. Metab. 89 (2004) 453-462
38. Sinclair R., et al. Treatment of female pattern hair loss with oral antiandrogens. Br. J. Dermatol. 152 (2005) 466-473
39. Munster U., et al. RU 58841-myristate - prodrug development for topical treatment of acne and androgenetic alopecia. Pharmazie 60 (2005) 8-12
40. Whiting D.A. Possible mechanisms of miniaturization during androgenetic alopecia or pattern hair loss. J. Am. Acad. Dermatol. 45 3 Suppl. (2001) S81-S86
41. Tobin D.J., et al. Plasticity and cytokinetic dynamics of the hair follicle mesenchyme: implications for hair growth control. J. Invest. Dermatol. 120 (2003) 895-904
42. Tumbar T., et al. Defining the epithelial stem cell niche in skin. Science 303 (2004) 359-363
43. Morris R.J., et al. Capturing and profiling adult hair follicle stem cells. Nat. Biotechnol. 22 (2004) 411-417
44. Ohyama M., et al. Characterization and isolation of stem cell-enriched human hair follicle bulge cells. J. Clin. Invest. 116 (2006) 249-260
45. Cotsarelis G. Gene expression profiling gets to the root of human hair follicle stem cells. J. Clin. Invest. 116 (2006) 19-22
46. Nakamura M., et al. Mutant laboratory mice with abnormalities in pilosebaceous unit development, growth and/or function. Exp. Dermatol. 10 (2001) 369-390
47. Green J., et al. A gene for pili annulati maps to the telomeric region of chromosome 12q. J. Invest. Dermatol. 123 (2004) 1070-1072
48. Horev L., et al. De novo mutations in monilethrix. Exp. Dermatol. 12 (2003) 882-885
49. Geyer A.S., et al. Netherton syndrome with extensive skin peeling and failure to thrive due to a homozygous frameshift mutation in SPINK5. Dermatology 210 (2005) 308-314
50. Hoffman R.M. Gene and stem cell therapy of the hair follicle. Methods Mol. Biol. 289 (2005) 437-448
51. Richardson G.D., et al. Plasticity of rodent and human hair follicle dermal cells: implications for cell therapy and tissue engineering. J. Investig. Dermatol. Symp. Proc. 10 (2005) 180-183
52. Stenn K.S., and Cotsarelis G. Bioengineering the hair follicle: fringe benefits of stem cell technology. Curr. Opin. Biotechnol. 16 (2005) 493-497
53. Reynolds A.J., et al. Trans-gender induction of hair follicles. Nature 402 (1999) 33-34
54. Sugiyama-Nakagiri Y., et al. Hair follicle stem cell-targeted gene transfer and reconstitution system. Gene Ther. 13 (2006) 732-737
55. Malkinson F.D., et al. Prostaglandins protect against murine hair injury produced by ionizing radiation or doxorubicin. J. Invest. Dermatol. 101 1 Suppl. (1993) 135S-137S
56. Cuscela D., et al. Protection from radiation-induced alopecia with topical application of nitroxides: fractionated studies. Cancer J. Sci. Am. 2 (1996) 273
57. Lozeron H., and Maggiora A. A propos of chemical radioprotection (agreements and disagreements of different tests). Dermatologica 131 (1965) 28-40
58. Gilhar A., and Kalish R.S. Alopecia Areata: a tissue specific autoimmune disease of the hair follicle. Autoimmun Rev. 5 (2006) 64-69
59. Stenn K.S., et al. Glucocorticoid effect on hair growth initiation: a reconsideration. Skin Pharmacol. 6 (1993) 125-134
60. Oh H.S., and Smart R.C. An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation. Proc. Natl. Acad. Sci. U S A 93 (1996) 12525-12530
61. Ohnemus U., et al. Hair cycle control by estrogens: catagen induction via estrogen receptor (ER)-alpha is checked by ER beta signaling. Endocrinology 146 (2005) 1214-1225
62. MacDonald Hull S.P., et al. Guidelines for the management of alopecia areata. Br. J. Dermatol. 149 (2003) 692-699
63. Philpott M.P., et al. Effects of insulin and insulin-like growth factors on cultured human hair follicles: IGF-I at physiologic concentrations is an important regulator of hair follicle growth in vitro. J. Invest. Dermatol. 102 (1994) 857-861
64. Itami S., and Inui S. Role of androgen in mesenchymal epithelial interactions in human hair follicle. J. Investig. Dermatol. Symp. Proc. 10 (2005) 209-211
65. Ito N., et al. Human hair follicles display a functional equivalent of the hypothalamic-pituitary-adrenal axis and synthesize cortisol. FASEB J. 19 (2005) 1332-1334
66. Cooper A., et al. Alpha-melanocyte-stimulating hormone suppresses antigen-induced lymphocyte proliferation in humans independently of melanocortin 1 receptor gene status. J. Immunol. 175 (2005) 4806-4813
67. Gatti S., et al. Alpha-melanocyte-stimulating hormone protects the allograft in experimental heart transplantation. Transplantation 74 (2002) 1678-1684
68. Luger T.A., et al. Cutaneous immunomodulation and coordination of skin stress responses by alpha-melanocyte-stimulating hormone. Ann. N. Y. Acad. Sci. 840 (1998) 381-394
69. Vogt A., et al. Follicular targeting - a promising tool in selective dermatotherapy. J. Investig. Dermatol. Symp. Proc. 10 (2005) 252-255
70. Randall J., and Ream E. Hair loss with chemotherapy: at a loss over its management?. Eur. J. Cancer Care (Engl.) 14 (2005) 223-231
71. Paus R., et al. Chemotherapy-induced alopecia in mice. Induction by cyclophosphamide, inhibition by cyclosporine A, and modulation by dexamethasone. Am. J. Pathol. 144 (1994) 719-734
72. Sharov A.A., et al. Fas signaling is involved in the control of hair follicle response to chemotherapy. Cancer Res. 64 (2004) 6266-6270
73. Botchkarev V.A. Molecular mechanisms of chemotherapy-induced hair loss. J. Investig. Dermatol. Symp. Proc. 8 (2003) 72-75
74. Grevelman E.G., and Breed W.P. Prevention of chemotherapy-induced hair loss by scalp cooling. Ann. Oncol. 16 (2005) 352-358 (Epub ahead of print)
75. Hendrix S., et al. A guide to assessing damage response pathways of the hair follicle: lessons from cyclophosphamide-induced alopecia in mice. J. Invest. Dermatol. 125 (2005) 42-51
76. Paus R., et al. Topical calcitriol enhances normal hair regrowth but does not prevent chemotherapy-induced alopecia in mice. Cancer Res. 56 (1996) 4438-4443
77. Ohnemus U., et al. Topical estrogen accelerates hair regrowth in mice after chemotherapy-induced alopecia by favoring the dystrophic catagen response to damage. J. Invest. Dermatol. 122 (2004) 7-13
78. Philpott M.P., et al. Whole hair follicle culture. Dermatol. Clin. 14 (1996) 595-607
79. Peters E.M., et al. P75 Neurotrophin receptor-mediated signaling promotes human hair follicle regression (catagen). Am. J. Pathol. 168 (2006) 221-234
80. Foitzik K., et al. Towards dissecting the pathogenesis of retinoid-induced hair loss: all trans retinoic acid induces premature hair follicle regression (catagen) by upregulation of transforming growth factor-beta2 in the dermal papilla. J. Invest. Dermatol. 124 (2005) 1119-1126
81. Foitzik K., et al. Human scalp hair follicles are both a target and a source of prolactin, which serves as an autocrine and/or paracrine promoter of apoptosis driven hair follicle regression. Am. J. Pathol. 168 (2006) 748-756
82. Philpott M.P., et al. Human hair growth in vitro. J. Cell Sci. 97 (1990) 463-471
83. Paus R., et al. Telogen skin contains an inhibitor of hair growth. Br. J. Dermatol. 122 (1990) 777-784
84. Slominski A., et al. Detection of proopiomelanocortin-derived antigens in normal and pathologic human skin. J. Lab. Clin. Med. 122 (1993) 658-6684
85. Kobayashi H., et al. A role of melatonin in neuroectodermal-mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors. FASEB J. 19 (2005) 1710-1712
86. Kromminga A., et al. Indications that normal human hair follicles have established a hypothalamic-pituitary-thyroid axis. Exp. Dermatol. 15 (2006) 256a
87. Laugsch M., et al. Human skin and hair follicles are targets and sources of erythropoietin. Exp. Dermatol. 15 (2006) 256a-257a
88. Arck P.C., et al. Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways. Am. J. Pathol. 162 (2003) 803-814
89. Peters E.M., et al. Neurogenic inflammation in stress-induced termination of murine hair growth is promoted by nerve growth factor. Am. J. Pathol. 165 (2004) 259-271
90. Arck P.C., et al. Mast cell deficient and neurokinin-1 receptor knockout mice are protected from stress-induced hair growth inhibition. J. Mol. Med. 83 (2005) 386-396
91. Arck P.C., et al. Topical minoxidil counteracts stress-induced hair growth inhibition in mice. Exp. Dermatol. 12 (2003) 580-590
92. Lin K.K., et al. Identification of hair cycle-associated genes from time-course gene expression profile data by using replicate variance. Proc. Natl. Acad. Sci. U S A 101 (2004) 15955-15960
93. Rendl M., et al. Molecular dissection of mesenchymal-epithelial interactions in the hair follicle. PLoS Biol. 3 (2005) e331
94. Ma L., et al. 'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation. Development 130 (2003) 379-389
95. Mecklenburg L., et al. Premature termination of hair follicle morphogenesis and accelerated hair follicle cycling in Iasi congenital atrichia (fzica) mice points to fuzzy as a key element of hair cycle control. Exp. Dermatol. 14 (2005) 561-570
96. Tosti A., et al. Hypertrichosis of the eyelashes caused by bimatoprost. J. Am. Acad. Dermatol. 51 5 Suppl. (2004) S149-S150 (Erratum in: J. Am. Acad. Dermatol. 2004; 51:1040)
97. Modschiedler K., et al. Hyperpigmentosis and hypertrichosis of the eyelids after use of bimatoprost eye drops. J. Dtsch. Dermatol. Ges. 3 (2005) 276-277
98. Sasaki S. Influence of prostaglandin F2alpha and its analogues on hair regrowth and follicular melanogenesis in a murine model. Exp. Dermatol. 14 (2005) 323-328
99. Namazi M.R. Prostaglandin analogs for hair growth: greater expectations. Dermatol. Online J. 9 (2003) 29
100. Schilli M.B., et al. Control of hair growth with parathyroid hormone (7-34). J. Invest. Dermatol. 108 (1997) 928-932
101. Peters E.M., et al. A new strategy for modulating chemotherapy-induced alopecia, using PTH/PTHrP receptor agonist and antagonist. J. Invest. Dermatol. 117 (2001) 173-178
102. Tsuruki T., and Yoshikawa M. Anti-alopecia effect of Gly-Leu-Phe, an immunostimulating peptide derived from alpha-lactalbumin. Biosci. Biotechnol. Biochem. 69 (2005) 1633-1635
103. Esfandiari A., and Kelley P. The effects of tea polyphenolic compounds on hair loss among rodents. J. Natl. Med. Assoc. 97 (2005) 816-818
104. Plonka P.M., et al. Zinc as an ambivalent but potent modulator of murine hair growth in vivo - preliminary observations. Exp. Dermatol. 14 (2005) 844-853
105. Ead R.D. Oral zinc sulphate in alopacia areata - a double blind trial. Br. J. Dermatol. 104 (1981) 483-484
106. Hirai Y., et al. Structural optimization of pep7, a small peptide extracted from epimorphin, for effective induction of hair follicle anagen. Exp. Dermatol. 14 (2005) 692-699
107. Rho S.S., et al. The hair growth promoting effect of Asiasari radix extract and its molecular regulation. J. Dermatol. Sci. 38 (2005) 89-97
108. Fischer T.W., et al. Melatonin increases anagen hair rate in women with androgenetic alopecia or diffuse alopecia: results of a pilot randomized controlled trial. Br. J. Dermatol. 150 (2004) 341-345
109. Tsuruki T., et al. Anti-alopecia mechanisms of soymetide-4, an immunostimulating peptide derived from soy beta-conglycinin. Peptides 26 (2005) 707-711
110. Sredni B., et al. Hair growth induction by the Tellurium immunomodulator AS101: association with delayed terminal differentiation of follicular keratinocytes and ras-dependent up-regulation of KGF expression. FASEB J. 18 (2004) 400-402
111. Philp D., et al. Thymosin beta4 increases hair growth by activation of hair follicle stem cells. FASEB J. 18 (2004) 385-387
112. Philp D., et al. Thymosin beta4 promotes angiogenesis, wound healing, and hair follicle development. Mech. Ageing Dev. 125 (2004) 113-115
113. Takahashi T., et al. The first clinical trial of topical application of procyanidin B-2 to investigate its potential as a hair growing agent. Phytother. Res. 15 (2001) 331-336
114. Kamimura A., and Takahashi T. Procyanidin B-3, isolated from barley and identified as a hair-growth stimulant, has the potential to counteract inhibitory regulation by TGF-beta1. Exp. Dermatol. 11 (2002) 532-541
115. Kamimura A., and Takahashi T. Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study. Br. J. Dermatol. 146 (2002) 41-51