Effect of colitis and ileoanal pouch on biliary enrichment of ursodeoxycholic acid in primary sclerosing cholangitis

Digestive Diseases and Sciences

Volumn 51, Issue 3, 2006, Pages 618-622

  Rost, D ^a   Rudolph, G ^a   Kloeters Plachky, P ^a   Stiehl, A ^a,b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Cholangitis; Colitis; Pouch; Ursodeoxycholic acid

Indexed keywords

BILE ACID; DEOXYCHOLIC ACID; LITHOCHOLIC ACID; URSODEOXYCHOLIC ACID;

ADULT; ARTICLE; BILE ACID METABOLISM; CLINICAL TRIAL; COLITIS; COLON; COLON RESECTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; ILEUM; MAJOR CLINICAL STUDY; PRIMARY SCLEROSING CHOLANGITIS; PRIORITY JOURNAL; PROCTOCOLECTOMY; SMALL INTESTINE;

ADULT; BILE ACIDS AND SALTS; CASE-CONTROL STUDIES; CHOLANGITIS, SCLEROSING; COLITIS; COLONIC POUCHES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MAXIMUM TOLERATED DOSE; PROBABILITY; REFERENCE VALUES; RISK ASSESSMENT; TREATMENT OUTCOME; URSODEOXYCHOLIC ACID;

EID: 33645855865     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-006-3180-5     Document Type: Article

References (33)

1. Poupon RE, Balkau B, Eschwege E, Poupon R: A multicenter controlled trial of ursodiol for the treatment of primary biliary cirrhosis. N Engl J Med 324:1548-1554, 1991
2. Lindor KDL, Dickson ER, Baldus WP, Jorgensen RA, Ludwig J, Murtaugh PA, Harrison JM, Wiesner RH, Anderson ML, Lange SM, Lesage G, Rossi SS, Hofmann AF: Ursodeoxycholic acid in the treatment of primary biliary cirrhosis. Gastroenterology 106:1284-1290, 1994
3. Poupon RE, Lindor KD, Cauch-Dudek K, Dickson ER, Poupon R, Heathcote EJ: Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis. Gastroenterology 113:884-890, 1997
4. Beuers U, Spengler U, Kruis W, Aydemir Š, Wiebecke B, Heldwein W, Weinzierl M, Pape GR, Sauerbruch T, Paumgartner G: Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: a placebo controlled trial. Hepatology 16:707-714, 1992
5. Lindor KD, Mayo PSC/UDCA Study Group: Ursodiol for the treatment of primary sclerosing cholangitis. N Engl J Med 336:691-695, 1997
6. Stiehl A, Rudolph G, Sauer P, Benz C, Stremmel W, Walker S, Theilmann L: Efficacy of ursodeoxycholic acid and endoscopic dilation of major duct stenoses in primary sclerosing cholangitis. An 8-year prospective study. J Hepatol 26:560-566, 1997
7. Mitchell SA, Bansi DS, Hunt N, von Bergmann K, Fleming BCA, Chapman RW: A preliminary trial of high dose ursodeoxycholic acid in primary sclerosing eholangitis: Results of a randomized double-blind placebo-controlled study. Gastroenterology 121:900-907, 2001
8. Stiehl A, Rudolph G, Kloeters-Plachky P, Sauer P, Walker S: Development of dominant bile duct stenoses in patients with primary aclerosing cholangitis treated with ursodeoxycholic acid: outcome after endoscopic treatment. J Hepatol 36:151-156, 2002
9. Stiehl A, Raedsch R, Rudolph G: Ileal excretion of bile acids: comparison with biliary bile acid composition and effect of ursodeoxycholic acid treatment. Gastroenterology 94:1201-1206, 1988
10. Walker S, Rudolph G, Raedsch R, Stiehl A: Intestinal absorption of ursodeoxycholic acid in patients with extrahepatic biliary obstruction and bile drainage. Gastroenterology 102:810-815, 1992
11. Sauer P, Benz C, Rudolph G, Kloeters-Plachky P, Stremmel W, Stiehl A: Influence of cholestasis on absorption of ursodeoxycholic acid. Dig Dis Sci 44:817-822, 1999
12. Fedorowski T, Salen G, Colallilo A, Tint GS, Mosbach EH, Hall JC: Metabolism of ursodeoxycholic acid in man. Gastroenterology 73:1131-1137, 1977
13. Fedorowski T, Salen G, Tint GS, Mosbach E: Transformation of chenodeoxycholic acid and ursodeoxycholic acid by human intestinal bacteria. Gastroenterology 77:1068-1073, 1979
14. Fromm H, Carlson GL, Hofmann AF, Farivar S, Amin P: Metabolism in man of 7-ketolithocholic acid: precursor of cheno- and ursodeoxycholic acid. Am J Physiol 239:G161-G166, 1980
15. Stiehl A, Raedsch R, Rudolph G: Acute effects of ursodeoxycholic acid and chenodeoxycholic acid on the small intestinal absorption of bile acids. Gastroenterology 98:424-428, 1990
16. Marteau P, Chazouilleres O, Myara A, Jian R, Rambaud JC, Poupon R: Effect of chronic administration of ursodeoxycholic acid on the ileal absorption of endogenous bile acids in man. Hepatology 12:1206-1208, 1990
17. Combes B, Carithers RL, Maddrey WC, Munoz S, Garcia-Tsao G, Bonner GF, Boyer JL, Luketic VA, Shiffman ML, Peters MG, White H, Zetterman RK, Risser R, Rossi SS, Hofmann AF: Biliary bile acids in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 29:1649-1654, 1999
18. Invernizzi P, Setchell KDR, Crosignani A, Battezzati PM, Larghi A, O'Conell N, Podda M: Differences in the metabolism and disposition of ursodeoxycholic acid and of its taurine-conjugated species in patients with primary biliary cirrhosis. Hepatology 29:320-327, 1999
19. Batta AK, Salen G, Arora R, Shefer S, Tint GS, Abroon J, Eskreis D, Katz S: Effect of ursodeoxycholic acid on bile acid metabolism in primary biliary cirrhosis. Hepatology 10:414-419, 1989
20. Crosignani A, Battezzati PM, Bertolini M, Zuin M, Watson D, Setchell KDR: Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration. Hepatology 14:1000-1007, 1991
21. Rost D, Rudolph G, Kloeters-Plachky P, Stiehl A: Effect of high dose ursodeoxycholic acid on its biliary enrichment in primary sclerosing eholangitis. Hepatology 40:693-698, 2004
22. Stiehl A, Raedsch R, Rudolph G, Czygan P, Walker S: Analysis of bile acid glucuronides in urine: group separation on a lipophilic anion exchanger. Clin Chim Acta 123:275-285, 1982
23. Alme B, Bremmelgaard A, Sjövall J, Thomassen P: Analysis of metabolic profiles of bile acid in urine using lipophilic anion exchanger and computerized gas liquid chromatography mass spectrometry. J Lipid Res 18:339-361, 1977
24. Palma J, Reyes H, Ribalta J, Iglesias J, Gonzalez MC, Hernandez I, Alvarez C, Molina C, Danitz AM: Effects of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy. Hepatology 15:1043-1047, 1992
25. Cotting J, Lentze MJ, Reichen J: Effects of ursodeoxycholic acid therapy on nutrition and liver function in patients with cystic fibrosis and long- standing cholestasis. Gut 31:918-921, 1990
26. Colombo C, Setchell KDR, Podda M, Crosignani A, Roda A, Curcio L, Ronchi M, Giunta A: Effects of ursodeoxycholic acid therapy for liver disease associated with cystic fibrosis. J Pediatr 117:482-489, 1990
27. Kitani K, Kitani S: Tauroursodeoxycholate prevents taurocholate-induced cholestasis. Life Sci 30:515-523, 1982
28. Galle PR, Theilmann L, Raedsch R, Otto G, Stiehl A: Ursodeoxycholate reduces hepatotoxicity of bile salts in primary human hepatocytes. Hepatology 12:486-491, 1990
29. Heuman DM, Mills AS, McCall J, Hylemon PB, Pandak M, Vlahcevic ZR: Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts: in vivo studies in rat. Gastroenterology 100:203-211, 1991
30. Tsukahara K, Kanai S, Ohta M, Kitani K: Taurine conjugate of ursodeoxycholate plays a major role in the hepatoprotective effect against cholestasis induced by taurochenodeoxycholate in rats. Liver 13:262-269, 1993
31. Heuman DM, Dajaj R: Ursodeoxycholate conjugates protect against disruption of cholesterol-rich membranes by bile salts. Gastroenterology 106:1333-1341, 1994
32. Benz C, Angermueller S, Töx U, Kloeters-Plachky P, Riedel HP, Sauer P, Stremmel W, Stiehl A: Effect of tauroursodeoxycholic acid on bile acid induced apoptosis and cytolysis in rat hepatocytes. J Hepatol 28:99-106, 1998
33. Rodrigues CM, Ma X, Linehan-Stieers C, Fan G, Kren BT, Steer J: Ursodeoxycholic acid prevents cytochrome C release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation. Cell Death Differ 6:842-854, 1999