Synthesis and SAR Studies of diarylpyrrole anticoccidial agents

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 10, 2006, Pages 2817-2821

  Qian, Xiaoxia ^a   Liang, Gui Bai ^a   Feng, Dennis ^a   Fisher, Michael ^a   Crumley, Tami ^a   Rattray, Sandra ^a   Dulski, Paula M ^a   Gurnett, Anne ^a   Leavitt, Penny Sue ^a   Liberator, Paul A ^a   Misura, Andrew S ^a   Samaras, Samantha ^a   Tamas, Tamas ^a   Schmatz, Dennis M ^a   Wyvratt, Matthew ^a   Biftu, Tesfaye ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Anticoccidial

Indexed keywords

2 PYRROLIDINE NITROGEN; COCCIDIOSTATIC AGENT; CYCLIC GMP DEPENDENT PROTEIN KINASE; DIMETHYLAMINE; PROTOZOAL PROTEIN; PYRROLE DERIVATIVE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTICOCCIDIAL ACTIVITY; ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; DRUG SCREENING; DRUG SYNTHESIS; EIMERIA TENELLA; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; COCCIDIOSTATS; CYCLIC GMP-DEPENDENT PROTEIN KINASES; EIMERIA TENELLA; ENZYME INHIBITORS; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP;

EIMERIA TENELLA;

EID: 33645851330     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.01.041     Document Type: Article

References (7)

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7. 1H NMR and LC-MS prior to submission for biological evaluation.