Regulation of flagella

Current Opinion in Microbiology

Volumn 9, Issue 2, 2006, Pages 180-186

  McCarter, Linda L ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REGULATOR PROTEIN;

BACTERIAL FLAGELLUM; BACTERIAL GENE; BACTERIAL GENETICS; BACTERIUM ADHERENCE; CHEMOTAXIS; FLAGELLUM; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; NONHUMAN; REGULATORY MECHANISM; REVIEW; SECRETION;

BACTERIA; BACTERIAL PROTEINS; FLAGELLA; GENE EXPRESSION REGULATION, BACTERIAL; LOCOMOTION; TRANSCRIPTION, GENETIC;

BACTERIA (MICROORGANISMS);

EID: 33645844248     PISSN: 13695274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mib.2006.02.001     Document Type: Review

References (65)

1. Aldridge P., and Hughes K.T. Regulation of flagellar assembly. Curr Opin Microbiol 5 (2002) 160-165
2. Soutourina O.A., and Bertin P.N. Regulation cascade of flagellar expression in Gram-negative bacteria. FEMS Microbiol Rev 27 (2003) 505-523
3. Limberger R.J. The periplasmic flagellum of spirochetes. J Mol Microbiol Biotechnol 7 (2004) 30-40
4. Macnab R.M. Type III flagellar protein export and flagellar assembly. Biochim Biophys Acta 1694 (2004) 207-217
5. Minamino T., and Namba K. Self-assembly and type III protein export of the bacterial flagellum. J Mol Microbiol Biotechnol 7 (2004) 5-17
6. Journet L., Hughes K.T., and Cornelis G.R. Type III secretion: a secretory pathway serving both motility and virulence (review). Mol Membr Biol 22 (2005) 41-50
7. Kojima S., and Blair D.F. The bacterial flagellar motor: structure and function of a complex molecular machine. Int Rev Cytol 233 (2004) 93-134
8. Daniels R., Vanderleyden J., and Michiels J. Quorum sensing and swarming migration in bacteria. FEMS Microbiol Rev 28 (2004) 261-289
9. Harshey R.M. Bacterial motility on a surface: many ways to a common goal. Annu Rev Microbiol 57 (2003) 249-273
10. Kirov S.M. Bacteria that express lateral flagella enable dissection of the multifunctional roles of flagella in pathogenesis. FEMS Microbiol Lett 224 (2003) 151-159
11. Rather P.N. Swarmer cell differentiation in Proteus mirabilis. Environ Microbiol 7 (2005) 1065-1073
12. McCarter L.L. Dual flagellar systems enable motility under different circumstances. J Mol Microbiol Biotechnol 7 (2004) 18-29
13. Ren C.P., Beatson S.A., Parkhill J., and Pallen M.J. The Flag-2 locus, an ancestral gene cluster, is potentially associated with a novel flagellar system from Escherichia coli. J Bacteriol 187 (2005) 1430-1440. Multiple strain sequencing has led to the discovery of a second flagellar system in some enteric genomes.
14. England J.C., and Gober J.W. Cell cycle control of cell morphogenesis in Caulobacter. Curr Opin Microbiol 4 (2001) 674-680
15. Sourjik V., Muschler P., Scharf B., and Schmitt R. VisN and VisR are global regulators of chemotaxis, flagellar, and motility genes in Sinorhizobium (Rhizobium) meliloti. J Bacteriol 182 (2000) 782-788
16. Dasgupta N., Wolfgang M.C., Goodman A.L., Arora S.K., Jyot J., Lory S., and Ramphal R. A four-tiered transcriptional regulatory circuit controls flagellar biogenesis in Pseudomonas aeruginosa. Mol Microbiol 50 (2003) 809-824. Transcriptional profiling using wild type and mutant strains was implemented to elucidate the P. aeruginosa flagellar hierarchy.
17. Jacobi S., Schade R., and Heuner K. Characterization of the alternative sigma factor sigma54 and the transcriptional regulator FleQ of Legionella pneumophila, which are both involved in the regulation cascade of flagellar gene expression. J Bacteriol 186 (2004) 2540-2547
18. ••], this work also used transcriptional profiling to determine the unique flagellar hierarchy of H. pylori; this hierarchy is pertinent to regulation in C. jejuni.
19. Hendrixson D.R., and DiRita V.J. Transcription of sigma54-dependent but not sigma28-dependent flagellar genes in Campylobacter jejuni is associated with formation of the flagellar secretory apparatus. Mol Microbiol 50 (2003) 687-702
20. Brahmachary P., Dashti M.G., Olson J.W., and Hoover T.R. Helicobacter pylori FlgR is an enhancer-independent activator of sigma54-RNA polymerase holoenzyme. J Bacteriol 186 (2004) 4535-4542
21. Correa N.E., Peng F., and Klose K.E. Roles of the regulatory proteins FlhF and FlhG in the Vibrio cholerae flagellar transcription hierarchy. J Bacteriol 187 (2005) 6324-6332
22. 54-dependent flagellar regulators in Rhodobacter sphaeroides. This work proposes that hierarchical transcription occurs in four tiers and is determined by the concentration of the activators and their interaction. These regulators are unusual, in that they both lack an amino-terminal regulatory domain and one lacks a DNA binding domain.
23. Motaleb M.A., Sal M.S., and Charon N.W. The decrease in FlaA observed in a flaB mutant of Borrelia burgdorferi occurs posttranscriptionally. J Bacteriol 186 (2004) 3703-3711
24. Amati G., Bisicchia P., and Galizzi A. DegU-P represses expression of the motility fla-che operon in Bacillus subtilis. J Bacteriol 186 (2004) 6003-6014
25. Fraser G.M., Hirano T., Ferris H.U., Devgan L.L., Kihara M., and Macnab R.M. Substrate specificity of type III flagellar protein export in Salmonella is controlled by subdomain interactions in FlhB. Mol Microbiol 48 (2003) 1043-1057. FlhB acts as a gate in the flagellar export apparatus to control substrate specificity. This work shows that subdomain interactions within FlhB, which are promoted by cleavage of FlhB, determine the specificity of gating.
26. Ferris H.U., Furukawa Y., Minamino T., Kroetz M.B., Kihara M., Namba K., and Macnab R.M. FLHB regulates ordered export of flagellar components via autocleavage mechanism. J Biol Chem 280 (2005) 41236-41242
27. Minamino T., Saijo-Hamano Y., Furukawa Y., Gonzalez-Pedrajo B., Macnab R.M., and Namba K. Domain organization and function of Salmonella FliK, a flagellar hook-length control protein. J Mol Biol 341 (2004) 491-502
28. Hirano T., Shibata S., Ohnishi K., Tani T., and Aizawa S. N-terminal signal region of FliK is dispensable for length control of the flagellar hook. Mol Microbiol 56 (2005) 346-360. FliK controls hook length; this study found that it does not need to be exported to exert this control, and, moreover, its absolute size is not crucial for function. Thus, FliK is unlikely to function as a molecular ruler.
29. Minamino T., and Pugsley A.P. Measure for measure in the control of type III secretion hook and needle length. Mol Microbiol 56 (2005) 303-308
30. 28 factor FlgM. Thus, this paper raises the interesting question of who is guarding whom, i.e. does the chaperone protect the substrate or does the substrate sequester a regulatory factor?
31. Dutton R.J., Xu Z., and Gober J.W. Linking structural assembly to gene expression: a novel mechanism for regulating the activity of a sigma transcription factor. Mol Microbiol 58 (2005) 743-757. This study showed that activity of the C. crescentus flagellar regulator FlbD can be controlled by direct physical interaction with an anti-activator protein.
32. Dasgupta N., and Ramphal R. Interaction of the antiactivator FleN with the transcriptional activator FleQ regulates flagellar number in Pseudomonas aeruginosa. J Bacteriol 183 (2001) 6636-6644
33. Llewellyn M., Dutton R.J., Easter J., O'Donnol D., and Gober J.W. The conserved flaF gene has a critical role in coupling flagellin translation and assembly in Caulobacter crescentus. Mol Microbiol 57 (2005) 1127-1142. Hierarchical transcription is not the sole means by which the assembly of flagella is regulated; translation also can be linked to assembly. This work deciphers how two proteins of C. crescentus influence translation and stability of flagellin mRNA.
34. Lai H.C., Soo P.C., Wei J.R., Yi W.C., Liaw S.J., Horng Y.T., Lin S.M., Ho S.W., Swift S., and Williams P. The RssAB two-component signal transduction system in Serratia marcescens regulates swarming motility and cell envelope architecture in response to exogenous saturated fatty acids. J Bacteriol 187 (2005) 3407-3414
35. Liaw S.J., Lai H.C., and Wang W.B. Modulation of swarming and virulence by fatty acids through the RsbA protein in Proteus mirabilis. Infect Immun 72 (2004) 6836-6845
36. Kim D.J., Boylan B., George N., and Forst S. Inactivation of ompR promotes precocious swarming and flhDC expression in Xenorhabdus nematophila. J Bacteriol 185 (2003) 5290-5294
37. Clarke M.B., and Sperandio V. Transcriptional regulation of flhDC by QseBC and sigma (FliA) in enterohaemorrhagic Escherichia coli. Mol Microbiol 57 (2005) 1734-1749
38. Majdalani N., Vanderpool C.K., and Gottesman S. Bacterial small RNA regulators. Crit Rev Biochem Mol Biol 40 (2005) 93-113
39. Tomoyasu T., Ohkishi T., Ukyo Y., Tokumitsu A., Takaya A., Suzuki M., Sekiya K., Matsui H., Kutsukake K., and Yamamoto T. The ClpXP ATP-dependent protease regulates flagellum synthesis in Salmonella enterica serovar Typhimurium. J Bacteriol 184 (2002) 645-653
40. Wolfe A.J., Chang D.E., Walker J.D., Seitz-Partridge J.E., Vidaurri M.D., Lange C.F., Pruss B.M., Henk M.C., Larkin J.C., and Conway T. Evidence that acetyl phosphate functions as a global signal during biofilm development. Mol Microbiol 48 (2003) 977-988
41. Bergara F., Ibarra C., Iwamasa J., Patarroyo J.C., Aguilera R., and Marquez-Magana L.M. CodY is a nutritional repressor of flagellar gene expression in Bacillus subtilis. J Bacteriol 185 (2003) 3118-3126
42. Calvio C., Celandroni F., Ghelardi E., Amati G., Salvetti S., Ceciliani F., Galizzi A., and Senesi S. Swarming differentiation and swimming motility in Bacillus subtilis are controlled by swrA, a newly identified dicistronic operon. J Bacteriol 187 (2005) 5356-5366. This study characterized a key regulatory locus controlling swimming and swarming in B. subtilis.
43. Yao S.Y., Luo L., Har K.J., Becker A., Ruberg S., Yu G.Q., Zhu J.B., and Cheng H.P. Sinorhizobium meliloti ExoR and ExoS proteins regulate both succinoglycan and flagellum production. J Bacteriol 186 (2004) 6042-6049
44. Clegg S., and Hughes K.T. FimZ is a molecular link between sticking and swimming in Salmonella enterica serovar Typhimurium. J Bacteriol 184 (2002) 1209-1213
45. Blumer C., Kleefeld A., Lehnen D., Heintz M., Dobrindt U., Nagy G., Michaelis K., Emody L., Polen T., Rachel R., et al. Regulation of type 1 fimbriae synthesis and biofilm formation by the transcriptional regulator LrhA of Escherichia coli. Microbiology 151 (2005) 3287-3298
46. Francez-Charlot A., Laugel B., Van Gemert A., Dubarry N., Wiorowski F., Castanie-Cornet M.P., Gutierrez C., and Cam K. RcsCDB His-Asp phosphorelay system negatively regulates the flhDC operon in Escherichia coli. Mol Microbiol 49 (2003) 823-832
47. Nachin L., Nannmark U., and Nystrom T. Differential roles of the universal stress proteins of Escherichia coli in oxidative stress resistance, adhesion, and motility. J Bacteriol 187 (2005) 6265-6272
48. Boles B.R., and McCarter L.L. Vibrio parahaemolyticus scrABC, a novel operon affecting swarming and capsular polysaccharide regulation. J Bacteriol 184 (2002) 5946-5954
49. Simm R., Morr M., Kader A., Nimtz M., and Romling U. GGDEF and EAL domains inversely regulate cyclic di-GMP levels and transition from sessility to motility. Mol Microbiol 53 (2004) 1123-1134
50. Jenal U. Cyclic di-guanosine-monophosphate comes of age: a novel secondary messenger involved in modulating cell surface structures in bacteria?. Curr Opin Microbiol 7 (2004) 185-191
51. Ellermeier C.D., and Slauch J.M. RtsA and RtsB coordinately regulate expression of the invasion and flagellar genes in Salmonella enterica serovar Typhimurium. J Bacteriol 185 (2003) 5096-5108
52. Teplitski M., Goodier R.I., and Ahmer B.M. Pathways leading from BarA/SirA to motility and virulence gene expression in Salmonella. J Bacteriol 185 (2003) 7257-7265
53. Grundling A., Burrack L.S., Bouwer H.G., and Higgins D.E. Listeria monocytogenes regulates flagellar motility gene expression through MogR, a transcriptional repressor required for virulence. Proc Natl Acad Sci USA 101 (2004) 12318-12323
54. Kalir S., and Alon U. Using a quantitative blueprint to reprogram the dynamics of the flagella gene network. Cell 117 (2004) 713-720. Based upon experimental data, a quantitative blueprint of flagellar gene expression was mathematically modeled and tested by using controlled expression of regulators. This work represents an exciting advance to probing and understanding complex genetic circuits.
55. McAdams H.H., and Shapiro L. A bacterial cell-cycle regulatory network operating in time and space. Science 301 (2003) 1874-1877. This work also describes a complex wiring diagram, in particular the CtrA regulatory network of C. crescentus. CtrA is a key regulator controlling the Caulobacter cell cycle and the determining regulator for the flagellar network.
56. 2 to the various flagellar promoters correlate with promoter strength and the timing of gene expression.
57. Kim Y.K., and McCarter L.L. Cross-regulation in Vibrio parahaemolyticus: compensatory activation of polar flagellar genes by the lateral flagellar regulator LafK. J Bacteriol 186 (2004) 4014-4018
58. Correa N.E., and Klose K.E. Characterization of enhancer binding by the Vibrio cholerae flagellar regulatory protein FlrC. J Bacteriol 187 (2005) 3158-3170
59. Millikan D.S., and Ruby E.G. FlrA, a sigma54-dependent transcriptional activator in Vibrio fischeri, is required for motility and symbiotic light-organ colonization. J Bacteriol 185 (2003) 3547-3557
60. Stewart B.J., and McCarter L.L. Lateral flagellar gene system of Vibrio parahaemolyticus. J Bacteriol 185 (2003) 4508-4518. This study mapped the three-tiered lateral flagellar transcriptional hierarchy by using mutant and fusion analyses.
61. Tomoyasu T., Takaya A., Isogai E., and Yamamoto T. Turnover of FlhD and FlhC, master regulator proteins for Salmonella flagellum biogenesis, by the ATP-dependent ClpXP protease. Mol Microbiol 48 (2003) 443-452
62. Crosson S., McAdams H., and Shapiro L. A genetic oscillator and the regulation of cell cycle progression in Caulobacter crescentus. Cell Cycle 3 (2004) 1252-1254
63. Dasgupta N., Ferrell E.P., Kanack K.J., West S.E., and Ramphal R. fleQ, the gene encoding the major flagellar regulator of Pseudomonas aeruginosa, is sigma70 dependent and is downregulated by Vfr, a homolog of Escherichia coli cyclic AMP receptor protein. J Bacteriol 184 (2002) 5240-5250
64. Williams T., Joseph B., Beier D., Goebel W., and Kuhn M. Response regulator DegU of Listeria monocytogenes regulates the expression of flagella-specific genes. FEMS Microbiol Lett 252 (2005) 287-298
65. Kearns D.B., Chu F., Rudner R., and Losick R. Genes governing swarming in Bacillus subtilis and evidence for a phase variation mechanism controlling surface motility. Mol Microbiol 52 (2004) 357-369. The authors describe the identification of a key regulatory locus swrA controlling flagellar regulation and swarming in B. subtilis.