Enhanced mass resolution method development, validation and assay application to support preclinical studies of a new drug candidate

Rapid Communications in Mass Spectrometry

Volumn 20, Issue 8, 2006, Pages 1240-1246

  Pucci, Vincenzo ^a   Bonelli, Fabio ^a   Monteagudo, Edith ^a   Laufer, Ralph ^a  

^a Merck Research Laboratories   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY;

BIOLOGICAL MATRIXES; DRUG CANDIDATES; LC-MS-MS; MASS RESOLUTION; METHOD DEVELOPMENT; PRECLINICAL STUDIES; RESOLUTION METHODS; SIMPLE++; TANDEM MASS SPECTROMETRIC; TRIPLE-QUADRUPOLE MASS SPECTROMETER;

CURVE FITTING;

EID: 33645843339     PISSN: 09514198     EISSN: 10970231     Source Type: Journal    
DOI: 10.1002/rcm.2439     Document Type: Article

References (11)

1. Covey TR, Lee EL, Henion J. Anal. Chem. 1986; 58: 2453.
2. Lee MS, Kerns EH. Mass Spectrom. Rev. 1999; 18: 187.
3. Bocxlaer JF, Clauwaert KM, Lambert WE, Deforce DL, Van den Eeckhout EG, De Leenheer AP. Mass Spectrom. Rev. 2000; 19: 165.
4. Hopfgartner G, Bourgogne E. Mass Spectrom. Rev. 2003; 22: 195.
5. Hughes N, Winnik W, Dunyach JJ, Amad M, Splendore M, Paul G. J. Mass Spectrom. 2003; 38: 743.
6. Pucci V, Monteagudo E, Bonelli F, Rapid Commun. Mass Spectrom. 2005; 19: 3713.
7. Xu X, Veals J, Korfmacher WA. Rapid Commun. Mass Spectrom. 2003; 17: 832.
8. Jemal M, Ouyang Z. Rapid Commun. Mass Spectrom. 2003; 17: 24.
9. Yang L, Amad M, Winnik WM, Schoen AE, Schweingruber H, Mylchreest I, Rudewicz PJ. Rapid Commun. Mass Spectrom. 2002; 16: 2060.
10. Harper S, Pacini B, Avolio S, Di Filippo M, Migliaccio G, Laufer R, De Francesco R, Rowley M, Narjes F. J. Med. Chem. 2005; 48: 1314.
11. Available: http://www.fda.gov/cder/guidance/4252fnl. htm#P199_14564.