Facile synthesis of α,α′ disubstituted N-hydroxypyrrolidines and N-hydroxypiperidines via double 1,4-addition of hydroxylamine

Tetrahedron Letters

Volumn 47, Issue 19, 2006, Pages 3191-3193

  Bargiggia, Frédéric C ^a   Murray, William V ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ESTER DERIVATIVE; HYDROXYLAMINE; PIPERIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; WATER;

ADDITION REACTION; ARTICLE; ROOM TEMPERATURE; SUBSTITUTION REACTION;

EID: 33645827567     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2006.03.064     Document Type: Article

References (11)

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11. 4 and the solvent evaporated under vacuum. The crude was purified by flash chromatography (typical eluant EtOAc/hexane 30/70).