Absence of L1 in pancreatic masses distinguishes adenocarcinomas from poorly differentiated neuroendocrine carcinomas

Anticancer Research

Volumn 26, Issue 2 A, 2006, Pages 1167-1170

  Kaifi, Jussuf T ^a   Heidtmann, Sina ^a   Schurr, Paulus G ^a   Reichelt, Uta ^a   Mann, Oliver ^a   Yekebas, Emre F ^a   Wachowiak, Robin ^a   Strate, Tim ^a   Schachner, Melitta ^a   Izbicki, Jakob R ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

L1 cell adhesion molecule; Pancreatic carcinoma; Tumor markers

Indexed keywords

CELL ADHESION MOLECULE; MONOCLONAL ANTIBODY; PARAFFIN; PEROXIDASE; PROTEIN CD 171; PROTEIN L 1; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ADULT; ARTICLE; CANCER STAGING; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; NEUROENDOCRINE TUMOR; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; STAINING;

ADENOCARCINOMA; CARCINOMA, NEUROENDOCRINE; FEMALE; HUMANS; LEUKOCYTE L1 ANTIGEN COMPLEX; MALE; MIDDLE AGED; NEOPLASM STAGING; PANCREATIC NEOPLASMS;

EID: 33645815934     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Greenlee RT, Hill-Harmon MB, Murray T and Thun M: Cancer statistics. CA Cancer J Clin 51(1): 15-36, 2001.
2. Parkin DM and Muir CS: Cancer incidence in five continents. Comparability and quality of data. IARC Sci Publ 120: 45-173, 1992.
3. Mosca F, Giulianotti PC, Balestracci T, Di Candio G, Pietrabissa A, Sbrana F and Rossi G: Long-term survival in pancreatic cancer: pylorus-preserving versus Whipple pancreatoduodenectomy. Surgery 122(3): 553-566, 1997.
4. Trede M, Schwall G and Saeger HD: Survival after pancreatoduodenectomy. 118 consecutive resections without an operative mortality. Ann Surg 211(4): 447-458, 1990.
5. Allema JH, Reinders ME, van Gulik TM, Koelemay MJ, Van Leeuwen DJ, de Wit LT, Gouma DJ and Obertop H: Prognostic factors for survival after pancreaticoduodenectomy for patients with carcinoma of the pancreatic head region. Cancer 75(8): 2069-2076, 1995.
6. Ohnishi T, Matsumura H, Izumoto S, Hiraga S and Hayakawa T: A novel model of glioma cell invasion using organotypic brain slice culture. Cancer Res 58(14): 2935-2940, 1998.
7. Schachner M: Neural recognition molecules and synaptic plasticity. Curr Opin Cell Biol 9(5): 627-634, 1997.
8. Brummendorf T, Kenwrick S and Rathjen FG: Neural cell recognition molecule L1: from cell biology to human hereditary brain malformations. Curr Opin Neurobiol 8(1): 87-97, 1998.
9. Hortsch M: The L1 family of neural cell adhesion molecules: old proteins performing new tricks. Neuron 17(4): 587-593, 1996.
10. De Angelis E, MacFarlane J, Du JS, Yeo G, Hicks R, Rathjen FG, Kenwrick S and Brummendorf T: Pathological missense mutations of neural cell adhesion molecule L1 affect homophilic and heterophilic binding activities. EMBO J 18(17): 4744-4753, 1999.
11. Oleszewski M, Beer S, Katich S, Geiger C, Zeller Y, Rauch U and Altevogt P: Integrin and neurocan binding to L1 involves distinct Ig domains. J Biol Chem 274(35): 24602-24610, 1999.
12. Fogel M, Mechtersheimer S, Huszar M, Smirnov A, Abu-Dahi A, Tilgen W, Reichrath J, Georg T, Altevogt P and Gutwein P: L1 adhesion molecule (CD 171) in development and progression of human malignant melanoma. Cancer Lett 189(2): 237-247, 2003.
13. Gil OD, Sakurai T, Bradley AE, Fink MY, Cassella MR, Kuo JA and Felsenfeld DP: Ankyrin binding mediates L1CAM interactions with static components of the cytoskeleton and inhibits retrograde movement of L1CAM on the cell surface. J Cell Biol 162(4): 719-730, 2003.
14. Gutwein P, Mechtersheimer S, Riedle S, Stoeck A, Gast D, Joumaa S, Zentgraf H, Fogel M and Altevogt DP: ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles. FASEB J 17(2): 292-294, 2003.
15. Kowitz A, Kadmon G, Verschueren H, Remels L, De Baetselier P, Hubbe M, Schachner M, Schirrmacher V and Altevogt P: Expression of L1 cell adhesion molecule is associated with lymphoma growth and metastasis. Clin Exp Metastasis 11(5): 419-429, 1993.
16. Linnemann D, Raz A and Bock E: Differential expression of cell adhesion molecules in variants of K1735 melanoma cells differing in metastatic capacity. Int J Cancer 43(4): 709-712, 1989.
17. Miyahara R, Tanaka F, Nakagawa T, Matsuoka K, Isii K and Wada H: Expression of neural cell adhesion molecules (polysialylated form of neural cell adhesion molecule and L1-cell adhesion molecule) on resected small cell lung cancer specimens: in relation to proliferation state. J Surg Oncol 77(1): 49-54, 2001.
18. Thies A, Schachner M, Moll I, Berger J, Schulze HJ, Brunner G and Schumacher U: Overexpression of the cell adhesion molecule L1 is associated with metastasis in cutaneous malignant melanoma. Eur J Cancer 38(13): 1708-1716, 2002.
19. Gutwein P, Oleszewski M, Mechtersheimer S, Agmon-Levin N, Krauss K and Altevogt P: Role of Src kinases in the ADAM-mediated release of L1 adhesion molecule from human tumor cells. J Biol Chem 275(20): 15490-15497, 2000.
20. Kalus I, Schnegelsberg B, Seidah NG, Kleene R and Schachner M: The proprotein convertase PC5A and a metalloprotease are involved in the proteolytic processing of the neural adhesion molecule L1. J Biol Chem 278(12): 10381-10388, 2003.
21. Mechtersheimer S, Gutwein P, Agmon-Levin N, Stoeck A, Oleszewski M, Riedle S, Postina R, Fahrenholz F, Fogel M, Lemmon V and Altevogt P: Ectodomain shedding of L1 adhesion molecule promotes cell migration by autocrine binding to integrins. J Cell Biol 155(4): 661-673, 2001.
22. Allory Y, Matsuoka Y, Bazille C, Christensen EI, Ronco P and Debiec H: The L1 cell adhesion molecule is induced in renal cancer cells and correlates with metastasis in clear cell carcinomas. Clin Cancer Res 11(3): 1190-1197, 2005.
23. Fogel M, Gutwein P, Mechtersheimer S, Riedle S, Stoeck A, Smirnov A, Edler L, Ben-Arie A, Huszar M and Altevogt P: L1 expression as a predictor of progression and survival in patients with uterine and ovarian carcinomas. Lancet 362(9387): 869-875, 2003.
24. Deichmann M, Kurzen H, Egner U, Altevogt P and Hartschuh W: Adhesion molecules CD171 (L1CAM) and CD24 are expressed by primary neuroendocrine carcinomas of the skin (Merkel cell carcinomas). J Cutan Pathol 30(6): 363-368, 2003.
25. Gavert N, Conacci-Sorrell M, Gast D, Schneider A, Altevogt P, Brabletz T and Ben-Ze'ev A: L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J Cell Biol 168(4): 633-642, 2005.
26. Kaifi JT, Zinnkann U, Yekebas EF, Schurr PG, Reichelt U, Wachowiak R, Fiegel H, Petri S, Schachner M and Izbicki JR: L1 cell adhesion molecule (CD171) as a potential marker for poorly differentiated pancreatic neuroendocrine carcinomas. World J Gastroenterol 12(1): 94-98, 2006.