Medical innovation, unmet medical need, and the drug pipeline

Canadian Journal of Clinical Pharmacology

Volumn 13, Issue 1, 2006, Pages

  Mather, Charles M ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Anthropology; Organizational efficiency; Recombinant DNA; Technical efficiency

Indexed keywords

ALTEPLASE; HUMAN GROWTH HORMONE; INTERLEUKIN 2; PENICILLIN G; RECOMBINANT DNA; RECOMBINANT HUMAN INSULIN; STREPTOKINASE; STREPTOMYCIN; INSULIN; TISSUE PLASMINOGEN ACTIVATOR;

ANTHROPOLOGY; ARTERY DISEASE; BLOOD CLOT; CANCER; CLINICAL TRIAL; DIABETES MELLITUS; DRUG APPROVAL; DRUG EFFICACY; DRUG INDUSTRY; HEALTH CARE NEED; HEART INFARCTION; HUMAN; NONHUMAN; PITUITARY DWARFISM; REVIEW; SHORT STATURE; STROKE; TREATMENT FAILURE; CHEMISTRY; DRUG THERAPY; EDITORIAL; ORGANIZATION AND MANAGEMENT; PHARMACEUTICS; PRODUCTIVITY; STATISTICS; SYNTHESIS;

DNA, RECOMBINANT; DRUG THERAPY; EFFICIENCY; HUMAN GROWTH HORMONE; HUMANS; INSULIN; TECHNOLOGY, PHARMACEUTICAL; TISSUE PLASMINOGEN ACTIVATOR;

EID: 33645802596     PISSN: 1198581X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (34)

1. Mather C. The pipeline and the porcupine: Alternate metaphors for the physician-industry relationship. Soc Sci Med 2005;60:1323-1334.
2. Mather C, Fleising U, Taylor L. Translating Knowledge from Bench to Bedside: The Controversial Social Life of t-PA. Risk Management: An International Journal 2004;6(2):47-58.
3. Spilker B. Multinational Pharmaceutical Companies. New York: Raven Press, 1989.
4. Economist. Hippocrates meet Mammon. The Economist 1990, Sep 22, 95.
5. Latour B. Science in Action. Cambridge: Cambridge University Press, 1987.
6. Strauss A. A social world perspective. Studies in Symbolic Interaction 1978;1:119-128.
7. Van Gennep A. The Rites of Passage. Translated by Vizedom MB, Caffee GL. Chicago: University of Chicago Press, 1960.
8. Turner V. The Forest of Symbols. Ithaca, N.Y.:Cornell University Press, 1967.
9. Appadurai A. The Social Life of Things: Commodities in Cultural Perspective. Cambridge: Cambridge University Press, 1986.
10. Van der Geest S, Whyte SR, and Hardon A. The anthropology of pharmaceuticals: a biographical approach. Annual Review of Anthropology 1996;25:153-178.
11. Fleising U. In search of genohype: A content analysis of biotechnology company documents. New Genetics and Society 2001;20(3):239-254.
12. Lock M, Scheper-Hughes N. A Critical-Interpretive Approach in Medical Anthropology: Rituals and Routines of Discipline and Dissent. In: Sargent CF, Johnson TM, eds. Medical Anthropology: Contemporary Theory and Method. Westport, CT: Praeger, 1996:41-70.
13. Star SL, Griesemer JR. Institutional ecology, 'translations' and boundary objects: Amateurs and professionals in Berkeley's museum of vertebrate zoology, 1907-1939. Social Studies of Science, 1989;19(3):387-420.
14. Van der Sluijs J, van Eijndhoven J, Shackley S, Wynne B. Anchoring devices in science for policy: The case for consensus around climate sensitivity. Social Studies of Science, 1998;28(2):291-323.
15. Fujimura J. Crafting Science: Standardized Packages, Boundary Objects and "Translation". In: Pickering A, ed. Science as Practice and Culture. Chicago: University of Chicago Press, 1992:168-211.
16. Abbott A. The System of Professions: An Essay on the Division of Expert Labor. Chicago: University of Chicago Press, 1989.
17. Lowy I. Between Bench and Bedside. Cambridge: Harvard University Press, 1996.
18. Goodell RS. (1979) Public Involvement in the DNA Controversy: The Case of Cambridge, Massachusetts. Science, Technology, and Human Values 1979;4(27):36-43.
19. Krimsky S. Genetic Alchemy: The Social History of the Recombinant DNA Controversy. Cambridge, Massachusetts: MIT Press, 1983.
20. Hughes SS. Making Dollars out of DNA: The First Major Patent in Biotechnology and the Commercialization of Biotechnology, 1974-1980. Isis 2001;92(3):541-575.
21. Waddell C. Reasonableness versus Rationality in the Construction and Justification of Science Policy Decisions: The Case of the Cambridge Experimentation Review Board. Science, Technology, and Human Values 1989;14 (1):7-25.
22. Wright S. Molecular Politics: Developing American and British Regulatory Policy for Genetic Engineering, 1972-1982. Chicago: University of Chicago Press, 1994.
23. McKelvey M. Evolutionary Innovations: The Business of Biotechnology. Oxford: Oxford University Press, 2000.
24. Bogner WC, Thomas H. (1996). Drugs to Market: Creating Value and Advantage in the Pharmaceutical Industry. New York: Pergamon, 1996.
25. Callahan P, Abboud L. A new boost for the vertically challenged - FDA panel gives initial nod to use of growth hormones for healthy but short kids. Wall Street Journal 2003; Eastern Edition, 11 June, pp. D.1.
26. 2Langreth R. Sweet syringe of youth. Forbes 2000;11 December, pp. 218.
27. Kolata G. New Growth Industry in Human Growth Hormone? Science 1986;234:22-24.
28. Cheseboro JH, Knatterud G, Roberts R, et al. Thrombolysis in myocardial infarction (TIMI) trial, phase 1: A comparison between intravenous plasminogen activator and intravenous streptokinase. Circulation 1987;76:142-54.
29. Barnett HJM, Buchan AM. The Imperative to Develop Dedicated Stroke Centers. JAMA 2000;283(23):3125-3126.
30. Indredavik B, Bakke F, Slørdahl SA, Rokseth R, Håheim LL. Stroke Unit Treatment Improves Long-term Quality of Life. Stroke 1998;29:895-899.
31. Lenzer J. Alteplase for stroke: money and optimistic claims buttress the "brain attack" campaign. British Medical Journal 2000;324:723-729.
32. Wolff SP. Trying times for 'human insulin'. Nature 1992;356(6368):375- 376.
33. Teuscher A, Berger WB. Hypoglycaemic unawareness in diabetics transferred from bee/porcine insulin to 'human insulin'. Lancet 1987;2(8555):382-385.
34. Greene K. Scientists battle spammers over HGH sales. Wall Street Journal 2003;June 12, pp. B.1.