The safety of extended consumption of freezing dryness Agaricus blazei (Iwade strain 101) Himematsutake

Japanese Pharmacology and Therapeutics

Volumn 34, Issue 1, 2006, Pages 103-117

  Kajimoto, Osami ^a   Ikeda, Yutaka ^b   Yabune, Mitsuharu ^c   Sakamoto, Akane ^c   Kajimoto, Yoshitaka ^c  

^a Osaka University of Foreign Studies   (Japan)

^b Shien Corporation

^c Soiken Inc   (Japan)

Author keywords

Agaricus blazei; Hepatic function; Safety

Indexed keywords

AGARICUS BLAZEI EXTRACT;

ADULT; AGARICUS BLAZEI; ANAMNESIS; ARTICLE; BLOOD EXAMINATION; CLINICAL ARTICLE; CONTROLLED STUDY; FOOD INTAKE; FREEZE DRYING; HUMAN; LIVER DYSFUNCTION; LIVER FUNCTION; PHYSICAL EXAMINATION; URINALYSIS;

EID: 33645796620     PISSN: 03863603     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Fukushima M, Nakano M, Morii Y, Ohashi T, Fujiwara Y, Sonoyama K. Hepatic LDL receptor mRNA in rats is increased by dietary mushroom (Agaricus bisporus) fiber and sugar beet fiber. J Nutr 2000; 130: 2151-6.
2. Manohar V, Talpur NA, Echard BW, Lieberman S, Preuss HG. Effects of a water-soluble extract of maitake mushroom on circulating glucose/insulin concentrations in KK mice. Diabetes Obes Metab 2002; 4: 43-8.
3. Otsuka M, Shinozuka K, Hirata G, Kunitomo M. Influences of a shiitake (Lentinus edodes)-fructo-oligosaccharide mixture (SK-204) on experimental pulmonary thrombosis in rats. Yakugaku Zasshi 1996; 116: 169-73.
4. Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol 1989; 35: 91-4.
5. Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol 1987; 33: 341-6.
6. Piraino F, Brandt CR. Isolation and partial characterization of an antiviral, RC-183, from the edible mushroom Rozites caperata. Antiviral Res 1999; 43: 67-78.
7. Ikekawa T, Uehara N, Maeda Y, Nakanishi M, Fukuoka F. Antitumor activity of aqueous extracts of edible mushrooms. Canser Res 1969; 29: 734-5.
8. Fujimiya Y, Suzuki Y, Oshiman K. Selective tumoricidal effect of soluble proteoglucan extracted from the basidiomycete, Agaricus blazei Murill, mediated via natural killer cell activation and apoptosis. Cancer Immunol Immunother 1998; 46: 147-59.
9. Nakajima A, Ishida T, Koga M, Takeushi T, Mazda O, Takeuchi M. Effect of hot water extract from Agaricus blazei Murill on antibody-producing cell in mice. Int Immunopharmacol 2002; 2: 1205-11.
10. Mizuno M, Morimoto M, Minato K, Tsuchida H. Polysaccharides from Agaricus blazai stimulate lymphocyte T-cell subsets in mice. Biosci Biotechnol Biochem 1998; 62: 434-7.
11. Kaneno R, Fontanari LM, Santos SA, Di Stashi LC, Rodrigues Filho E, Eira AF. Effects of extracts from Brazilian sun-mushroom (Agaricus blazei) on the NK activity and lymphoproliferative responsiveness of Ehrlich tumor-bearing mice.
12. Ebina T, Fujimiya Y. Antitumor effect of a peptide-glucan preparation extracted from Agaricus blazei in a double-grafted tumor system in mice. Biotherapy 1998; 11: 259-65.
13. Mizuno M, Minato K, Ito H, Kawade M, Terai H, Tsuchida H. Anti-tumor polysaccharide from the mycelium of liquid-cultured Agaricus blazei mill. Biochem Mol Biol Int 1999; 47: 707-14.
14. Kawagishi H, Kanao T, Inagaki R, Mizuno T. Formolysis of a potent antitumor (1→6)-β-D-glucan-protem complex from Agaricus blazei fruiting bodies and antitumor activity of the resulting products. Carbohydrate Polymer 1990; 12: 393-403.
15. Ito H, Shimura K, Ito H, Kawabe M. Antitumor effects of a new polysaccharide-protein complex (ATOM) prepared from Agaricus blazei (Iwade strain 101) "Himematsutake" and its mechanisums in tumor-bearing mice. Anticancer Res 1997; 17: 277-84.
16. Chen L, Shao HJ, Su YB. Coimmunization of Agaricus blazei Murill extract with hepatitis B virus core protein through DNA vaccine enhances cellular and humoral immune Int Immunopharmacol 2004; 4: 403-9.
17. Barbisan LF, Miyamoto M, Scolastici C, Salvadori DM, Ribeiro LR, Eira AF, et al. Influence of aqueous extract of Agaricus blazei on rat liver toxicity indused by different doses of diethylnitrosamine. J Ethnopharmacol 2002; 83: 25-32.
18. Pross HF, Lotzova E. Role of natural killer cells in cancer. Nat Immun 1993; 12: 279-92.
19. Whiteside TL, Herberman RB. The role of natural killer cells in immune surveillance of cancer. Curr Opin Immunol 1995; 7: 704-10.
20. Lode HN, Xiang R, Dreier T, Varki NM, Gillies SD, Reisfedl RA. Natural killer cell-mediated eradication of neuroblastoma metastases to bone marrow by targeted interleukin-2 therapy. Blood 1998; 91: 1706-15.
21. Kay RM. Dietary fiber. J Lipid Res 1982; 23: 221-42.