메뉴 건너뛰기




Volumn 23, Issue 3, 2006, Pages 263-270

A randomised, controlled clinical trial evaluating changes in therapeutic efficacy and oxidative parameters after treatment with propionyl L-carnitine in patients with peripheral arterial disease requiring haemodialysis

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYNONENAL; MALONALDEHYDE; NITRATE; NITRITE; PLACEBO; PROPIONYLCARNITINE;

EID: 33645790536     PISSN: 1170229X     EISSN: 1170229X     Source Type: Journal    
DOI: 10.2165/00002512-200623030-00008     Document Type: Article
Times cited : (38)

References (35)
  • 1
    • 0035999921 scopus 로고    scopus 로고
    • Anemia and left ventricular hypertrophy in chronic kidney disease populations: A review of the current state of knowledge
    • Levin A. Anemia and left ventricular hypertrophy in chronic kidney disease populations: a review of the current state of knowledge. Kidney Int Suppl 2002; (80): 35-8
    • (2002) Kidney Int Suppl , Issue.80 , pp. 35-38
    • Levin, A.1
  • 2
    • 0042574210 scopus 로고    scopus 로고
    • Cardiovascular disease in chronic renal failure: Pathophysiologic aspects
    • London GM. Cardiovascular disease in chronic renal failure: pathophysiologic aspects. Semin Dial 2003; 16 (2): 85-94
    • (2003) Semin Dial , vol.16 , Issue.2 , pp. 85-94
    • London, G.M.1
  • 3
    • 0034079643 scopus 로고    scopus 로고
    • Cardiovascular disease and chronic renal disease: A new paradigm
    • Sarnak MJ, Levey AS. Cardiovascular disease and chronic renal disease: a new paradigm. Am J Kidney Dis 2000; 35 (4 Suppl. 1): S117-31
    • (2000) Am J Kidney Dis , vol.35 , Issue.4 SUPPL. 1
    • Sarnak, M.J.1    Levey, A.S.2
  • 4
    • 0033057143 scopus 로고    scopus 로고
    • The clinical epidemiology of cardiac disease in chronic renal failure
    • Parfrey PS, Foley RN. The clinical epidemiology of cardiac disease in chronic renal failure. J Am Soc Nephrol 1999; 10 (7): 1606-15
    • (1999) J Am Soc Nephrol , vol.10 , Issue.7 , pp. 1606-1615
    • Parfrey, P.S.1    Foley, R.N.2
  • 5
    • 0032229725 scopus 로고    scopus 로고
    • Epidemiology of cardiovascular risk factors in chronic renal disease
    • Coresh J, Longenecker JC, Miller 3rd ER, et al. Epidemiology of cardiovascular risk factors in chronic renal disease. J Am Soc Nephrol 1998; 9 (12 Suppl.): S24-30
    • (1998) J Am Soc Nephrol , vol.9 , Issue.12 SUPPL.
    • Coresh, J.1    Longenecker, J.C.2    Miller III, E.R.3
  • 6
    • 0033937001 scopus 로고    scopus 로고
    • Atherosclerotic cardiovascular disease risks in chronic hemodialysis patients
    • Cheung AK, Sarnak MJ, Yan G, et al. Atherosclerotic cardiovascular disease risks in chronic hemodialysis patients. Kidney Int 2000; 58 (1): 353-62
    • (2000) Kidney Int , vol.58 , Issue.1 , pp. 353-362
    • Cheung, A.K.1    Sarnak, M.J.2    Yan, G.3
  • 7
    • 1642458138 scopus 로고    scopus 로고
    • High prevalence of peripheral arterial disease in persons with renal insufficiency: Results from the National Health and Nutrition Examination Survey 1999-2000
    • O'Hare AM, Glidden DV, Fox CS, et al. High prevalence of peripheral arterial disease in persons with renal insufficiency: results from the National Health and Nutrition Examination Survey 1999-2000. Circulation 2004; 109 (3): 320-3
    • (2004) Circulation , vol.109 , Issue.3 , pp. 320-323
    • O'Hare, A.M.1    Glidden, D.V.2    Fox, C.S.3
  • 8
    • 0036243494 scopus 로고    scopus 로고
    • Prevalence of lower extremity arterial disease defined by the ankle-brachial index among American Indians: The Inter-Tribal Heart Project
    • Lamar Welch VL, Casper M, Greenlund K, et al. Prevalence of lower extremity arterial disease defined by the ankle-brachial index among American Indians: the Inter-Tribal Heart Project. Ethn Dis 2002; 12 (1): S1-63-7
    • (2002) Ethn Dis , vol.12 , Issue.1
    • Lamar Welch, V.L.1    Casper, M.2    Greenlund, K.3
  • 10
    • 4444305406 scopus 로고    scopus 로고
    • Role of nutrition for cardiovascular risk reduction in chronic kidney disease patients
    • Ikizler TA. Role of nutrition for cardiovascular risk reduction in chronic kidney disease patients. Adv Chronic Kidney Dis 2004; 11 (2): 162-71
    • (2004) Adv Chronic Kidney Dis , vol.11 , Issue.2 , pp. 162-171
    • Ikizler, T.A.1
  • 11
    • 0038044769 scopus 로고    scopus 로고
    • Effects of vitamin supplementation on microcirculatory disturbance in hemodialysis patients without peripheral arterial disease
    • Sato M, Matsumoto Y, Morita H, et al. Effects of vitamin supplementation on microcirculatory disturbance in hemodialysis patients without peripheral arterial disease. Clin Nephrol 2003; 60 (1): 28-34
    • (2003) Clin Nephrol , vol.60 , Issue.1 , pp. 28-34
    • Sato, M.1    Matsumoto, Y.2    Morita, H.3
  • 12
    • 0141988641 scopus 로고    scopus 로고
    • Antioxidants in peripheral arterial disease
    • Violi F, Loffredo L, Mancini A, et al. Antioxidants in peripheral arterial disease. Curr Drug Targets 2003; 4 (8): 651-5
    • (2003) Curr Drug Targets , vol.4 , Issue.8 , pp. 651-655
    • Violi, F.1    Loffredo, L.2    Mancini, A.3
  • 13
    • 0035153678 scopus 로고    scopus 로고
    • Advanced glycation end products, their receptors and diabetic angiopathy
    • Wautier JL, Guillausseau PJ. Advanced glycation end products, their receptors and diabetic angiopathy. Diabetes Metab 2001; 27 (5 Pt 1): 535-42
    • (2001) Diabetes Metab , vol.27 , Issue.5 PART 1 , pp. 535-542
    • Wautier, J.L.1    Guillausseau, P.J.2
  • 14
    • 0012738864 scopus 로고    scopus 로고
    • Pharmacokinetics of L-carnitine
    • Evans AM, Fornasini G. Pharmacokinetics of L-carnitine. Clin Pharmacokinet 2003; 42 (11): 941-67
    • (2003) Clin Pharmacokinet , vol.42 , Issue.11 , pp. 941-967
    • Evans, A.M.1    Fornasini, G.2
  • 15
    • 0019325901 scopus 로고
    • Relationship between acid-soluble carnitine and coenzyme A pools in vivo
    • Brass EP, Hoppel CL. Relationship between acid-soluble carnitine and coenzyme A pools in vivo. Biochem J 1980; 190 (3): 495-504
    • (1980) Biochem J , vol.190 , Issue.3 , pp. 495-504
    • Brass, E.P.1    Hoppel, C.L.2
  • 16
    • 0030844417 scopus 로고    scopus 로고
    • Technetium-99m sestamibi leg scintigraphy for non-invasive assessment of propionyl-L-carnitine induced changes in skeletal muscle metabolism
    • Cittanti C, Colamussi P, Giganti M, et al. Technetium-99m sestamibi leg scintigraphy for non-invasive assessment of propionyl-L-carnitine induced changes in skeletal muscle metabolism. Eur J Nucl Med 1997; 24 (7): 762-6
    • (1997) Eur J Nucl Med , vol.24 , Issue.7 , pp. 762-766
    • Cittanti, C.1    Colamussi, P.2    Giganti, M.3
  • 17
    • 0026009064 scopus 로고
    • Muscle carnitine deficiency in patients with severe peripheral vascular disease
    • Brevetti G, Angelini C, Rosa M, et al. Muscle carnitine deficiency in patients with severe peripheral vascular disease. Circulation 1991; 84 (4): 1490-5
    • (1991) Circulation , vol.84 , Issue.4 , pp. 1490-1495
    • Brevetti, G.1    Angelini, C.2    Rosa, M.3
  • 18
    • 0034769731 scopus 로고    scopus 로고
    • Effects of ischaemic stress on leukocyte activation processes in patients with chronic peripheral occlusive arterial disease: Role of L-propionyl carnitine administration
    • Signorelli SS, Malaponte G, Di Pino L, et al. Effects of ischaemic stress on leukocyte activation processes in patients with chronic peripheral occlusive arterial disease: role of L-propionyl carnitine administration. Pharmacol Res 2001; 44 (4): 305-9
    • (2001) Pharmacol Res , vol.44 , Issue.4 , pp. 305-309
    • Signorelli, S.S.1    Malaponte, G.2    Di Pino, L.3
  • 19
    • 4644278071 scopus 로고    scopus 로고
    • Impact of hemodialysis on endogenous plasma and muscle carnitine levels in patients with end-stage renal disease
    • Evans AM, Faull RJ, Nation RL, et al. Impact of hemodialysis on endogenous plasma and muscle carnitine levels in patients with end-stage renal disease. Kidney Int 2004; 66 (4): 1527-34
    • (2004) Kidney Int , vol.66 , Issue.4 , pp. 1527-1534
    • Evans, A.M.1    Faull, R.J.2    Nation, R.L.3
  • 20
    • 1242342233 scopus 로고    scopus 로고
    • Serum carnitine concentrations correlated to clinical outcome parameters in chronic hemodialysis patients
    • Steiber AL, Weatherspoon LJ, Spry L, et al. Serum carnitine concentrations correlated to clinical outcome parameters in chronic hemodialysis patients. Clin Nutr 2004; 23 (1): 27-34
    • (2004) Clin Nutr , vol.23 , Issue.1 , pp. 27-34
    • Steiber, A.L.1    Weatherspoon, L.J.2    Spry, L.3
  • 21
    • 0037381302 scopus 로고    scopus 로고
    • A review of the impact of L-carnitine therapy on patient functionality in maintenance hemodialysis
    • Miller B, Ahmad S. A review of the impact of L-carnitine therapy on patient functionality in maintenance hemodialysis. Am J Kidney Dis 2003; 41 (4 Suppl. 4): S44-8
    • (2003) Am J Kidney Dis , vol.41 , Issue.4 SUPPL. 4
    • Miller, B.1    Ahmad, S.2
  • 22
    • 0036192012 scopus 로고    scopus 로고
    • Effects of L-carnitine supplementation in maintenance hemodialysis patients: A systematic review
    • Hurot JM, Cucherat M, Haugh M, et al. Effects of L-carnitine supplementation in maintenance hemodialysis patients: a systematic review. J Am Soc Nephrol 2002; 13 (3): 708-14
    • (2002) J Am Soc Nephrol , vol.13 , Issue.3 , pp. 708-714
    • Hurot, J.M.1    Cucherat, M.2    Haugh, M.3
  • 23
    • 0035011124 scopus 로고    scopus 로고
    • Intravenous L-carnitine increases plasma carnitine, reduces fatigue, and may preserve exercise capacity in hemodialysis patients
    • Brass EP, Adler S, Sietsema KE, et al. Intravenous L-carnitine increases plasma carnitine, reduces fatigue, and may preserve exercise capacity in hemodialysis patients. Am J Kidney Dis 2001; 37 (5): 1018-28
    • (2001) Am J Kidney Dis , vol.37 , Issue.5 , pp. 1018-1028
    • Brass, E.P.1    Adler, S.2    Sietsema, K.E.3
  • 25
    • 0034456018 scopus 로고    scopus 로고
    • 4-Hydroxynonenal in the pathomechanisms of oxidative stress
    • Poli G, Schaur RJ. 4-Hydroxynonenal in the pathomechanisms of oxidative stress. IUBMB Life 2000; 50 (4-5): 315-21
    • (2000) IUBMB Life , vol.50 , Issue.4-5 , pp. 315-321
    • Poli, G.1    Schaur, R.J.2
  • 26
    • 0037411282 scopus 로고    scopus 로고
    • 4-Hydroxy-2-nonenal: A product and mediator of oxidative stress
    • Uchida K. 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog Lipid Res 2003; 42 (4): 318-43
    • (2003) Prog Lipid Res , vol.42 , Issue.4 , pp. 318-343
    • Uchida, K.1
  • 27
    • 0029149021 scopus 로고
    • Colorimetric methods for the determination of nitric oxide concentration in neutral aqueous solutions
    • Nims R, Derbyshire J, Saavedra J, et al. Colorimetric methods for the determination of nitric oxide concentration in neutral aqueous solutions. Methods 1995; 7: 48-54
    • (1995) Methods , vol.7 , pp. 48-54
    • Nims, R.1    Derbyshire, J.2    Saavedra, J.3
  • 28
    • 0019201951 scopus 로고
    • Pyruvate carboxylase and propionyl-CoA carboxylase as anaplerotic enzymes in skeletal muscle mitochondria
    • Davis EJ, Spydevold O, Bremer J. Pyruvate carboxylase and propionyl-CoA carboxylase as anaplerotic enzymes in skeletal muscle mitochondria. Eur J Biochem 1980; 110 (1): 255-62
    • (1980) Eur J Biochem , vol.110 , Issue.1 , pp. 255-262
    • Davis, E.J.1    Spydevold, O.2    Bremer, J.3
  • 29
    • 0026683401 scopus 로고
    • Skeletal muscle carnitine metabolism in patients with unilateral peripheral arterial disease
    • Hiatt WR, Wolfel EE, Regensteiner JG, et al. Skeletal muscle carnitine metabolism in patients with unilateral peripheral arterial disease. J Appl Physiol 1992; 73 (1): 346-53
    • (1992) J Appl Physiol , vol.73 , Issue.1 , pp. 346-353
    • Hiatt, W.R.1    Wolfel, E.E.2    Regensteiner, J.G.3
  • 30
    • 0023905696 scopus 로고
    • Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: A double-blind, cross-over study
    • Brevetti G, Chiariello M, Ferulano G, et al. Increases in walking distance in patients with peripheral vascular disease treated with L-carnitine: a double-blind, cross-over study. Circulation 1988; 77 (4): 767-73
    • (1988) Circulation , vol.77 , Issue.4 , pp. 767-773
    • Brevetti, G.1    Chiariello, M.2    Ferulano, G.3
  • 31
    • 0034619027 scopus 로고    scopus 로고
    • Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): Randomised placebo-controlled trial
    • Boaz M, Smetana S, Weinstein T, et al. Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial. Lancet 2000; 356 (9237): 1213-8
    • (2000) Lancet , vol.356 , Issue.9237 , pp. 1213-1218
    • Boaz, M.1    Smetana, S.2    Weinstein, T.3
  • 32
    • 0037471546 scopus 로고    scopus 로고
    • Critical issues in peripheral arterial disease detection and management: A call to action
    • Belch JJ, Topol EJ, Agnelli G, et al. Critical issues in peripheral arterial disease detection and management: a call to action. Arch Intern Med 2003; 163 (8): 884-92
    • (2003) Arch Intern Med , vol.163 , Issue.8 , pp. 884-892
    • Belch, J.J.1    Topol, E.J.2    Agnelli, G.3
  • 33
    • 0026501734 scopus 로고
    • Mortality over a period of 10 years in patients with peripheral arterial disease
    • Criqui MH, Langer RD, Fronek A, et al. Mortality over a period of 10 years in patients with peripheral arterial disease. N Engl J Med 1992; 326 (6): 381-6
    • (1992) N Engl J Med , vol.326 , Issue.6 , pp. 381-386
    • Criqui, M.H.1    Langer, R.D.2    Fronek, A.3
  • 34
    • 0037394435 scopus 로고    scopus 로고
    • Renal insufficiency as a predictor of cardiovascular outcomes and mortality in elderly individuals
    • Fried LF, Shlipak MG, Crump C, et al. Renal insufficiency as a predictor of cardiovascular outcomes and mortality in elderly individuals. J Am Coll Cardiol 2003; 41 (8): 1364-72
    • (2003) J Am Coll Cardiol , vol.41 , Issue.8 , pp. 1364-1372
    • Fried, L.F.1    Shlipak, M.G.2    Crump, C.3
  • 35
    • 33646564106 scopus 로고    scopus 로고
    • Effect of PLC on functional parameters and oxidative profile in type 2 diabetes-associated PAD
    • In press
    • Signorelli S, Neri S, Di Pino L, et al. Effect of PLC on functional parameters and oxidative profile in type 2 diabetes-associated PAD. Diabetes Res Clin Pract. In press
    • Diabetes Res Clin Pract
    • Signorelli, S.1    Neri, S.2    Di Pino, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.