A review of the impact of L-carnitine therapy on patient functionality in maintenance hemodialysis

American Journal of Kidney Diseases

Volumn 41, Issue 4 SUPPL. 4, 2003, Pages

  Miller, Brent ^a   Ahmad, Suhail ^b  

^a BARNES JEWISH HOSPITAL   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Chronic renal failure (CRF); Dialysis; End stage renal disease (ESRD); Exercise; Functionality; Kidney failure; L carnitine; Levocarnitine; Muscle; Myopathy; Uremia

Indexed keywords

CARNITINE;

CARNITINE DEFICIENCY; CHRONIC KIDNEY FAILURE; CLINICAL TRIAL; DAILY LIFE ACTIVITY; EXERCISE; HEMODIALYSIS; HUMAN; KIDNEY FAILURE; MUSCLE CRAMP; MUSCLE WEAKNESS; MYOPATHY; QUALITY OF LIFE; REVIEW; TREATMENT OUTCOME; WELLBEING;

EID: 0037381302     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0272-6386(03)00116-1     Document Type: Review

References (23)

1. Wolcott DL: Psychosocial rehabilitation of adult dialysis patients, in Nissenson AR, Fine RN (eds): Dialysis Therapy (ed 2). Philadelphia, PA, Hanley & Belfus, 1993, pp 335-340
2. Ahmad S, Robertson HT, Golper TA, et al: Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kidney Int 38:912-918, 1990
3. Bellinghieri G, Savica V, Mallamace A, et al: Correlation between increased serum and tissue L-carnitine levels and improved muscle symptoms in hemodialyzed patients. Am J Clin Nutr 38:523-531, 1983
4. Brass EP, Adler S, Sietsema KE, et al: Intravenous L-carnitine increases plasma carnitine, reduces fatigue, and may preserve exercise capacity in hemodialysis patients. Am J Kidney Dis 37:1018-1028, 2001
5. Casciani CU, Caruso U, Cravotto E, et al: Beneficial effects of L-carnitine in post-dialysis syndrome. Curr Ther Res 33:116-127, 1982
6. Fagher B, Cederblad G, Eriksson M, et al: L-Carnitine and haemodialysis: Double blind study on muscle function and metabolism and peripheral nerve function. Scand J Clin Lab Invest 45:169-178, 1985
7. Feinfeld DA, Kurian P, Cheng JT, et al: Effect of oral L-carnitine on serum myoglobin in hemodialysis patients. Ren Fail 18:91-96, 1996
8. Giovenali P, Fenocchio D, Montanari G, et al: Selective trophic effect of L-carnitine in type I and IIa skeletal muscle fibers. Kidney Int 46:1616-1619, 1994
9. Rocchi L, Feola I, Calvani M, et al: Effects of carnitine administration in patients with chronic renal failure undergoing periodic dialysis, evaluated by computerized electromyography. Drugs Exp Clin Res 12:707-711, 1986
10. Rogerson ME, Rylance PB, Wilson R, et al: Carnitine and weakness in haemodialysis patients. Nephrol Dial Transplant 4:366-371, 1989
11. Sakurauchi Y, Matsumoto Y, Shinzato T, et al: Effects of L-carnitine supplementation on muscular symptoms in hemodialyzed patients. Am J Kidney Dis 32:258-264, 1998
12. Semeniuk J, Shalansky KF, Taylor N, et al: Evaluation of the effect of intravenous L-carnitine on quality of life in chronic hemodialysis patients. Clin Nephrol 54:470-477, 2000
13. Siami G, Clinton ME, Mrak R, et al: Evaluation of the effect of intravenous L-carnitine therapy on function, structure and fatty acid metabolism of skeletal muscle in patients receiving chronic hemodialysis. Nephron 57:306-313, 1991
14. Sloan RS, Kastan B, Rice SI, et al: Quality of life during and between hemodialysis treatments: Role of L-carnitine supplementation. Am J Kidney Dis 32:265-272, 1998
15. Sohn HJ, Choi GB, Yoon KI: L-Carnitine in maintenance hemodialysis: Clinical, lipid and biochemical effects. Korean J Nephrol 2:260-268, 1992
16. Spagnoli LG, Palmieri G, Mauriello A, et al: Morphometric evidence of the trophic effect of L-carnitine on human skeletal muscle. Nephron 55:16-23, 1990
17. Painter P, Stewart AL, Carey S: Physical functioning: Definitions, measurement, and expectations. Adv Ren Replace Ther 6:110-123, 1999
18. Curtin RB, Lowrie EG, DeOreo PB: Self-reported functional status: An important predictor of health outcomes among end-stage renal disease patients. Adv Ren Replace Ther 6:133-140, 1999
19. DeOreo PB: Hemodialysis patient-assessed functional health status predicts continued survival, hospitalization, and dialysis-attendance compliance. Am J Kidney Dis 30:204-212, 1997
20. Goral S: Levocarnitine's role in the treatment of patients with end-stage renal disease: A review. Dial Transpl 30:530-538, 2001
21. Hiatt WR, Koziol BJ, Shapiro JI, Brass EP: Carnitine metabolism during exercise in patients on chronic hemodialysis. Kidney Int 41:1613-1619, 1992
22. Mujais SK: Muscle cramps during hemodialysis. Int J Artif Organs 17:570-572, 1994
23. Sklar AH, Riesenberg LA, Silber AK, et al: Postdialysis fatigue. Am J Kidney Dis 28:732-736, 1996