메뉴 건너뛰기




Volumn 5, Issue 1, 2006, Pages 25-29

Pentoxifylline does not prevent neither liver damage nor early profibrogenic events in a rat model of non-alcoholic steatohepatitis

Author keywords

Choline deficient diet; Fatty liver disease; Liver fibrosis; Pentoxifylline; Steatohepatitis

Indexed keywords

ALPHA ACTIN; AMINOTRANSFERASE; CHOLINE; COLLAGEN TYPE 1; DRINKING WATER; GLUTATHIONE; MESSENGER RNA; PENTOXIFYLLINE; PROCOLLAGEN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 33645789349     PISSN: 16652681     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1665-2681(19)32035-6     Document Type: Article
Times cited : (9)

References (29)
  • 1
    • 0038644536 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Summary of an AASLD Single Topic Conference
    • Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 2003; 37: 1202-1219.
    • (2003) Hepatology , vol.37 , pp. 1202-1219
    • Neuschwander-Tetri, B.A.1    Caldwell, S.H.2
  • 2
    • 17444417085 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Adams LA, Angulo P, Lindor KD. Nonalcoholic fatty liver disease. CMAJ 2005; 172: 899-905.
    • (2005) CMAJ , vol.172 , pp. 899-905
    • Adams, L.A.1    Angulo, P.2    Lindor, K.D.3
  • 3
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-1231.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 5
    • 8744254513 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH): Diagnosis and clinical course
    • Cortez-Pinto H, Camilo ME. Non-alcoholic fatty liver disease/nonalcoholic steatohepatitis (NAFLD/NASH): diagnosis and clinical course. Best Pract Res Clin Gastroenterol 2004; 18: 1089-1104.
    • (2004) Best Pract Res Clin Gastroenterol , vol.18 , pp. 1089-1104
    • Cortez-Pinto, H.1    Camilo, M.E.2
  • 6
    • 0036302288 scopus 로고    scopus 로고
    • Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma
    • Bugianesi E, Leone N, Vanni E, Marchesini G, Brunello F, Carucci P, Musso A, et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology 2002; 123: 134-140.
    • (2002) Gastroenterology , vol.123 , pp. 134-140
    • Bugianesi, E.1    Leone, N.2    Vanni, E.3    Marchesini, G.4    Brunello, F.5    Carucci, P.6    Musso, A.7
  • 7
    • 13544258741 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: Recent advances from experimental models to clinical management
    • Portincasa P, Grattagliano I, Palmieri VO, Palasciano G. Nonalcoholic steatohepatitis: recent advances from experimental models to clinical management. Clin Biochem 2005; 38: 203-217.
    • (2005) Clin Biochem , vol.38 , pp. 203-217
    • Portincasa, P.1    Grattagliano, I.2    Palmieri, V.O.3    Palasciano, G.4
  • 8
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"?
    • Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology 1998; 114: 842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 9
    • 0036454882 scopus 로고    scopus 로고
    • Non-alcoholic steatohepatitis: Definitions and pathogenesis
    • Day C, Saksena S. Non-alcoholic steatohepatitis: Definitions and pathogenesis. J Gastroenterol Hepatol 2002; 17 Suppl 3: S377-S384.
    • (2002) J Gastroenterol Hepatol , vol.17 , Issue.3 SUPPL.
    • Day, C.1    Saksena, S.2
  • 11
    • 12144291550 scopus 로고    scopus 로고
    • Oxidative stress-related parameters in the liver of nonalcoholic fatty liver disease patients
    • Lond
    • Videla LA, Rodrigo R, Orellana M, Fernandez V, Tapia G, Quinones L, Varela N, et al. Oxidative stress-related parameters in the liver of nonalcoholic fatty liver disease patients. Clin Sci (Lond) 2004; 106: 261-268.
    • (2004) Clin Sci , vol.106 , pp. 261-268
    • Videla, L.A.1    Rodrigo, R.2    Orellana, M.3    Fernandez, V.4    Tapia, G.5    Quinones, L.6    Varela, N.7
  • 12
    • 4344666158 scopus 로고    scopus 로고
    • Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease
    • Diehl AM. Tumor necrosis factor and its potential role in insulin resistance and nonalcoholic fatty liver disease. Clin Liver Dis 2004; 8: 619-638.
    • (2004) Clin Liver Dis , vol.8 , pp. 619-638
    • Diehl, A.M.1
  • 14
    • 0033030541 scopus 로고    scopus 로고
    • Effect of pentoxifylline on early proliferation and phenotypic modulation of fibrogenic cells in two rat models of liver fibrosis and on cultured hepatic stellate cells
    • Desmouliere A, Xu G, Costa AM, Yousef IM, Gabbiani G, Tuchweber B. Effect of pentoxifylline on early proliferation and phenotypic modulation of fibrogenic cells in two rat models of liver fibrosis and on cultured hepatic stellate cells. J Hepatol 1999; 30: 621-631.
    • (1999) J Hepatol , vol.30 , pp. 621-631
    • Desmouliere, A.1    Xu, G.2    Costa, A.M.3    Yousef, I.M.4    Gabbiani, G.5    Tuchweber, B.6
  • 15
    • 0035200125 scopus 로고    scopus 로고
    • Effects of pentoxifylline on the different steps during adhesion and transendothelial migration of flowing neutrophils
    • Bahra PS, Rainger GE, Wautier JL, Nash GB. Effects of pentoxifylline on the different steps during adhesion and transendothelial migration of flowing neutrophils. Cell Biochem Funct 2001; 19: 249-257.
    • (2001) Cell Biochem Funct , vol.19 , pp. 249-257
    • Bahra, P.S.1    Rainger, G.E.2    Wautier, J.L.3    Nash, G.B.4
  • 16
    • 0030795195 scopus 로고    scopus 로고
    • Pentoxifylline inhibits growth and collagen synthesis of cultured human hepatic myofibroblast-like cells
    • Preaux AM, Mallat A, Rosenbaum J, Zafrani ES, Mavier P. Pentoxifylline inhibits growth and collagen synthesis of cultured human hepatic myofibroblast-like cells. Hepatology 1997; 26: 315-322.
    • (1997) Hepatology , vol.26 , pp. 315-322
    • Preaux, A.M.1    Mallat, A.2    Rosenbaum, J.3    Zafrani, E.S.4    Mavier, P.5
  • 17
    • 0036155891 scopus 로고    scopus 로고
    • Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis
    • Raetsch C, Jia JD, Boigk G, Bauer M, Hahn EG, Riecken E-O, Schuppan D. Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression in rat secondary biliary fibrosis. Gut 2002; 50: 241-247.
    • (2002) Gut , vol.50 , pp. 241-247
    • Raetsch, C.1    Jia, J.D.2    Boigk, G.3    Bauer, M.4    Hahn, E.G.5    Riecken, E.-O.6    Schuppan, D.7
  • 18
    • 4644224457 scopus 로고    scopus 로고
    • Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet
    • Koppe SW, Sahai A, Malladi P, Whitington PF, Green RM. Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet. J Hepatol 2004; 41: 592-598.
    • (2004) J Hepatol , vol.41 , pp. 592-598
    • Koppe, S.W.1    Sahai, A.2    Malladi, P.3    Whitington, P.F.4    Green, R.M.5
  • 19
    • 11144249271 scopus 로고    scopus 로고
    • A pilot trial of pentoxifylline in nonalcoholic steatohepatitis
    • Adams LA, Zein CO, Angulo P, Lindor KD. A pilot trial of pentoxifylline in nonalcoholic steatohepatitis. Am J Gastroenterol 2004; 99: 2365-2368.
    • (2004) Am J Gastroenterol , vol.99 , pp. 2365-2368
    • Adams, L.A.1    Zein, C.O.2    Angulo, P.3    Lindor, K.D.4
  • 20
    • 7044269614 scopus 로고    scopus 로고
    • Beneficial effects of tumor necrosis factor-alpha inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis
    • Satapathy SK, Garg S, Chauhan R, Sakhuja P, Malhotra V, Sharma BC, Sarin SK. Beneficial effects of tumor necrosis factor-alpha inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2004; 99: 1946-1952.
    • (2004) Am J Gastroenterol , vol.99 , pp. 1946-1952
    • Satapathy, S.K.1    Garg, S.2    Chauhan, R.3    Sakhuja, P.4    Malhotra, V.5    Sharma, B.C.6    Sarin, S.K.7
  • 21
    • 0033741433 scopus 로고    scopus 로고
    • Correlation between stellate cell activation and serum fibrosis markers in choline-deficient Lamino acid-defined diet-induced rat liver fibrosis
    • Hironaka K, Sakaida I, Uchida K, Okita K. Correlation between stellate cell activation and serum fibrosis markers in choline-deficient Lamino acid-defined diet-induced rat liver fibrosis. Dig Dis Sci 2000; 45: 1935-1943.
    • (2000) Dig Dis Sci , vol.45 , pp. 1935-1943
    • Hironaka, K.1    Sakaida, I.2    Uchida, K.3    Okita, K.4
  • 22
    • 0842308111 scopus 로고    scopus 로고
    • Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet
    • Kawaguchi K, Sakaida I, Tsuchiya M, Omori K, Takami T, Okita K. Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. Biochem Biophys Res Commun 2004; 315: 187-195.
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 187-195
    • Kawaguchi, K.1    Sakaida, I.2    Tsuchiya, M.3    Omori, K.4    Takami, T.5    Okita, K.6
  • 23
    • 0022272493 scopus 로고
    • Determination of glutathione and glutathione disulfide in biological samples
    • Anderson ME. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol 1985; 113: 548-555.
    • (1985) Methods Enzymol , vol.113 , pp. 548-555
    • Anderson, M.E.1
  • 24
  • 25
  • 26
    • 0030858931 scopus 로고    scopus 로고
    • Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis
    • Windmeier C, Gressner AM. Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis. Gen Pharmacol 1997; 29: 181-196.
    • (1997) Gen Pharmacol , vol.29 , pp. 181-196
    • Windmeier, C.1    Gressner, A.M.2
  • 27
    • 0037542941 scopus 로고    scopus 로고
    • In vivo inefficiency of pentoxifylline and interferon-alpha on hepatic fibrosis in biliary-obstructed rats: Assessment by tissue collagen content and prolidase activity
    • Tarcin O, Avsar K, Demirturk L, Gultepe M, Oktar BK, Ozdogan OC, Baloglu H, et al. In vivo inefficiency of pentoxifylline and interferon-alpha on hepatic fibrosis in biliary-obstructed rats: assessment by tissue collagen content and prolidase activity. J Gastroenterol Hepatol 2003; 18: 437-444.
    • (2003) J Gastroenterol Hepatol , vol.18 , pp. 437-444
    • Tarcin, O.1    Avsar, K.2    Demirturk, L.3    Gultepe, M.4    Oktar, B.K.5    Ozdogan, O.C.6    Baloglu, H.7
  • 28
    • 29144523498 scopus 로고    scopus 로고
    • Lessons from animal models of NASH
    • Diehl AM. Lessons from animal models of NASH. Hepatol Res 2005.
    • (2005) Hepatol Res
    • Diehl, A.M.1
  • 29


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.