Improvements in the status of folate and cobalamin in pregnant newfoundland women are consistent with observed reductions in the incidence of neural tube defects

Canadian Journal of Public Health

Volumn 97, Issue 2, 2006, Pages 132-135

  House, James D ^a   March, Sandra B ^b   Ratnam, Sam ^b   Crowley, Marilyn ^c   Friel, James K ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b Newfoundland and Labrador Public Health Laboratory   (Canada)

^c MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

Cobalamin; Folic acid; Homocysteine; Neural tube defects

Indexed keywords

COBALAMIN; FOLIC ACID; HOMOCYSTEINE;

ADOLESCENT; ADULT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIETARY INTAKE; FEMALE; FOLIC ACID BLOOD LEVEL; GEOGRAPHIC DISTRIBUTION; GESTATION PERIOD; HEALTH PROGRAM; HEALTH SURVEY; HUMAN; INCIDENCE; MATERNAL NUTRITION; NEURAL TUBE DEFECT; POPULATION DISTRIBUTION; PREGNANCY; PRENATAL CARE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RISK REDUCTION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; VITAMIN BLOOD LEVEL;

EID: 33645781763     PISSN: 00084263     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03405331     Document Type: Article

References (21)

1. Canada Gazette Part II. Regulatory impact analysis statement, SOR/98-550. 1998;132:3029-33.
2. Food and Drug Administration. Food standards: Amendment of the standards of identity for enriched grain products to require addition of folic acid - Final rule. Fed Reg 1996;61:8781-97.
3. Medical Research Council Vitamin Study Research Group. Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study. Lancet 1991;338:131-37.
4. Czeizel AE, Dudas I. Prevention of the first occurrence of neural tube defects by periconceptional vitamin supplementation. N Engl J Med 1992;327:1832-35.
5. Werler MM, Shapiro S, Mitchell AA. Periconceptional folic acid exposure and risk of occurent neural tube defects. JAMA 1993;269:1257-61.
6. Frecker ME. Neural tube defects in Newfoundland. J Epidemiol Community Health 1994;48:100.
7. House JD, Brosnan JT, Ives E, Ratnam S, Friel JK. Folate and B12 status of pregnant Newfoundland women. CMAJ 2000;162:1557-59.
8. Vester B, Rasmussen K. High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum. Eur J Clin Chem Clin Biochem 1991;29:549-54.
9. De Wals P, Rusen ID, Lee NS, Morin P, Niyonsenga T. Trend in prevalence of neural tube defects in Quebec. Birth Defects Res Part A Clin Mol Teratol 2003;67:919-23.
10. House JD, Jacobs RL, Stead LM, Brosnan ME, Brosnan JT. Regulation of homocysteine metabolism. Adv Enzyme Regul 1999;39:69-91.
11. Ray JG, Vermeulen MJ, Boss SC, Cole DEC. Increased red cell folate concentrations in women of reproductive age after Canadian Folic Acid Food Fortification. Epidemiology 2002;13:238-40.
12. Ray JG, Meier C, Vermeulen MJ, Boss S, Wyatt PR, Cole DEC. Association of neural tube defects and folic acid fortification in Canada. Lancet 2002;360:2047-48.
13. Persad VL, Van den Hof MC, Dubé JM, Zimmer P. Incidence of open neural tube defects in Nova Scotia after folic acid fortification. CMAJ 2002;167:241-45.
14. Daly S, Mills JL, Molloy AM, Conley M, Lee YJ, Kirke PN, et al. Minimum effective dose of folic acid for food fortification to prevent neural-tube defects. Lancet 1997;350:1666-69.
15. Friel JK, Frecker M, Fraser FC. Nutritional patterns of mothers of children with neural tube defects in Newfoundland. Am J Med Genet 1995;55:195-99.
16. Crane JMG, Sun C, Hutchens D, Crowley M. The epidemiology of neural tube defects in Newfoundland and Labrador. J Soc Obstet Gynaecol Can 2001;23:510-14.
17. Ray JG, Blom HJ. Vitamin B12 insufficiency and the risk of fetal neural tube defects. Q J Med 2003;96:289-95.
18. De Bree A, Verschuren WM, Kromhout D, Kluijtmans LA, Blom HJ. Homocysteine determinants and the evidence to what extent homocysteine determines the risk of coronary heart disease. Pharmacol Rev 2002;54:599-618.
19. Morris MS. Homocysteine and Alzheimer's disease. Lancet Neurol 2003;2:425-28.
20. McLean RR, Jacques PF, Selhub, J, Tucker KL, Samelson EJ, Broe KE, et al. Homocysteine as a predictive factor for hip fracture in older persons. N Engl J Med 2004;350:2042-49.
21. McNulty H. Increasing evidence in favor of mandatory fortification with folic acid. Br J Nutr 2001;86:425-26.