Modeling aggregate exposures to glycol ethers from use of commercial floor products

International Journal of Toxicology

Volumn 25, Issue 2, 2006, Pages 95-107

  Koontz, Michael ^a   Price, Paul ^b   Hamilton, John ^c   Daggett, Daniel ^c   Sielken, Robert ^d   Bretzlaff, Robert ^d   Tyler, Tipton ^e,f  

^a GEOMET Technologies   (United States)

^b LifeLine Group   (United States)

^c JohnsonDiversey Inc   (United States)

^d Sielken & Associates Inc   (United States)

^e Health Studies Management and Consulting   (United States)

^f NONE   (United States)

Author keywords

Dose; Exposure; Floor Products; Glycol Ethers; Modeling; Multiroute

Indexed keywords

2 BUTOXYETHANOL; DIPROPYLENE GLYCOL METHYL ETHER; ETHER DERIVATIVE; UNCLASSIFIED DRUG;

AIR; ARTICLE; BUILDING; CHEMICAL INDUSTRY; COMPUTER PROGRAM; INHALATION; MAXIMUM ALLOWABLE CONCENTRATION; MODEL; MONTE CARLO METHOD; OCCUPATIONAL EXPOSURE; PARAMETER; SIMULATION; WORKPLACE;

ADULT; AIR POLLUTANTS; AIR POLLUTION, INDOOR; ENVIRONMENTAL MONITORING; ETHYLENE GLYCOLS; FLOORS AND FLOORCOVERINGS; HUMANS; INHALATION EXPOSURE; INTESTINAL ABSORPTION; MALE; MODELS, THEORETICAL; MONTE CARLO METHOD; OCCUPATIONAL EXPOSURE; PROPYLENE GLYCOLS; SKIN ABSORPTION; SOLVENTS; THRESHOLD LIMIT VALUES; UNCERTAINTY;

EID: 33645761430     PISSN: 10915818     EISSN: 1092874X     Source Type: Journal    
DOI: 10.1080/10915810600605724     Document Type: Article

References (29)

1. ASHRAE. 1989. Ventilation for acceptable indoor air quality. June 1989. Atlanta, GA: American Society of Heating, Refrigerating and Air-Conditioning Engineers, Inc. Standard, ASHRAE 62-1989.
2. Bartnik, F. G., A. K. Reddy, G. Klecak, Y. Zimmermann, J. J. Hostynek, and K. Kunstler. 1987. Percutaneous absorption, metabolism, and hemolytic activity of n-butoxyethanol. Fundam. Appl. Toxicol. 8:59-70.
3. Boatman, R. J., and J. B. Knaak. 2001. Ethers of ethylene glycol and derivatives. In Patty's toxicology, 5th ed., Vol. 7, ed. E. Bingham, B. Cohrssen, and C. H. Powell, 73-270. New York: John Wiley & Sons.
4. Burmaster, D. E. 1996. Benefits and costs of using probabilistic techniques in human health risk assessments - with an emphasis on site-specific risk assessments. Hum. Ecol. Risk Assess. 2:35-43.
5. Chinn, H., E. Anderson, and M. Yoneyama. 2000. CEH marketing research report. Glycol ethers. SRI International, Menlo Park, CA.
6. Corley, R. A., G. A. Bormett, and B. I. Ghanyem. 1994. Physiologically based pharmacokinetics of 2-butoxyethanol and its major metabolite, 2-butoxyacetic acid, in rats and humans. Toxicol. Appl. Pharmacol. 129:61-79.
7. Corley, R. A., D. A. Markham, C. Banks, P. Delorme, A. Masterman, and J. M. Haul. 1997. Physiologically baseed pharmacokinetics and the dermal absorption of 2,-butoxyethanol vapor by humans. Fundam. Appl. Toxicol. 39:120-130.
8. Cragg, S. T., and R. J. Boatman. 2001. Glycol ethers: Ethers of propylene, butylene glycols, and other glycol derivatives. In Patty's toxicology, 5th ed., Vol. 7, ed. E. Bingham, B. Cohrssen, and C. H. Powell, 271-395. New York: John Wiley & Sons.
9. Dugard, P. H., M. Walker, S. J. Mawdsley, and R. C. Scott. 1984. Absorption of some glycol ethers through human skin in vitro. Environ. Health Perspect. 57:193-198.
10. ECETOC. 2005. The toxicology of glycol ethers and its relevance to man, 4th ed., Vol. I. Technical Report No. 95. Brussels: European Centre for Ecotoxicology and Toxicology of Chemicals.
11. Evans, W. C. 1994. Development of continuous-application source terms and analytical solutions for one- and two-compartment systems. In characterizing sources of indoor air pollution and related sink effects, 297-293. ASTM STP 1287. American Society for Testing and Materials, West Conshohocken, PA.
12. Finley, B., and D. Paustenbach. 1994. The benefits of probabilistic exposure assessment: Three case studies involving contaminated air, water, and soil. Risk Anal. 53:54-57.
13. Hertwich, E., T. E. McKone, and W. S. Pease. 1999. A systematic uncertainty analysis of an evaluative fate and exposure model. Risk Anal. 20:439-454.
14. ISSA. 1999. 358 Cleaning times. The International Sanitary Supply Association (ISSA), Lincolnwood, IL.
15. Jayjock, M. 1994. Back pressure modeling of indoor air concentration from volatilizing sources. Am. Ind. Hyg. Assoc. J. 5:230-235.
16. Johanson, G. 1986. Physiologically based pharmacokinetic modeling of inhaled 2-butoxyethanol in man. Toxicol Lett. 34:23-31.
17. Koontz, M. D. 1992. Consumer products exposure guidelines: Evaluation of indoor air quality models. Final report for USEPA Office of Research and Development, Environmental Monitoring Systems Laboratory. Las Vegas: GEOMET Technologies, Inc.
18. Koontz, M. D., and H. R. Rector. 1995. Estimation of distributions for residential air exchange rates. Final report for USEPA Office of Pollution Prevention and Toxics. Las Vegas: GEOMET Technologies, Inc.
19. McCready, D., and D. Fontaine. 2003. Estimating volatilization and exposure to constituents in surface coatings; models versus experiments. Paper no. 70369. 96th Annual Meeting of Air & Waste Management Association, San Diego, CA.
20. Nagda, N., and M. Koontz. 1991. A multichamber model for assessing consumer inhalation exposure. Indoor Air 4:593-605.
21. Persily, A. K. 1989. Ventilation rates in office buildings. IAQ 1989. Atlanta, GA: American Society of Heating, Refrigerating and Air-Conditioning Engineers, Inc., pp 128-136.
22. Robinson, J. P., and J. A. Wiley. 1989. Activity patterns of California residents. Berkeley, CA: Survey Research Center, University of California. ARB Contract No. A6-177-33.
23. Sparks, L. E., B. A. Tichenor, J. Chang, and Z. Guo. 1996. Gas-phase mass transfer model for predicting volatile organic compound (VOC) emission rates from indoor pollutant sources. Indoor Air 6:31-40.
24. Sweeny, L. M., T. R. Tyler, C. R. Kirman, R. A. Corley, R. H. Reitz, D. J. Paustenbach, J. F. Holson, M. D. Whorton, K. M. Thompson, and M. L. Gargas. 2001. Proposed occupational exposure limits for select ethylene glycol ethers using PBPK models and Monte Carlo simulations. Toxicol. Sci. 62:124-139.
25. USEPA. 1997. Exposure factors handbook. EPA/600/P-95/002Fa.
26. Van Veen, M. 1996. A general model for exposure and uptake from consumer products. Risk Anal. 16:331-338.
27. Venier, M., G. Adami, F. Larese, G. Maina, and N. Remzi. 2004. Percutaneous absorption of 5 glycol ethers through human skin in vitro. Toxicol. In Vitro 18:665-671.
28. Versar, Inc. 1992. A laboratory method to determine the retention of liquids on the surface of hands. Washington, DC: U.S. Environmental Protection Agency, Office of Pollution Prevention and Toxics. EPA Contract No. 68-02-4254.
29. Wilkinson, S. C., and F. M. Williams. 2002. Effects of experimental conditions on the absorption of glycol ethers through human skin in vitro. Int. Arch Occup. Environ. Health 75:519-527.