Comparative pathogenesis of recombinant rabies vaccine strain SAD-L16 and SAD-D29 with replacement of Arg333 in the glycoprotein after peripheral inoculation of neonatal mice: Less neurovirulent strain is a stronger inducer of neuronal apoptosis

Acta Neuropathologica

Volumn 111, Issue 4, 2006, Pages 372-378

  Jackson, Alan C ^a   Rasalingam, Pamini ^a   Weli, Simon C ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Encephalitis; Neurovirulence; Pathogenesis; Rabies; Virulence

Indexed keywords

ARGININE; ASPARTIC ACID; CASPASE 3; RABIES VACCINE; VIRUS ANTIGEN; VIRUS GLYCOPROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN NERVE CELL; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GRANULAR CELL; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INOCULATION; KAPLAN MEIER METHOD; LIMB WEAKNESS; MALE; MORTALITY; MOUSE; NEOSTRIATUM; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RABIES VIRUS; STATISTICAL SIGNIFICANCE; TEGMENTUM; VIRUS ATTENUATION; VIRUS ENCEPHALITIS; VIRUS PATHOGENESIS; VIRUS STRAIN; VIRUS TRANSMISSION; VIRUS VIRULENCE;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BRAIN; FEMALE; GLYCOPROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MICE; MICE, INBRED ICR; NEURONS; RABIES VACCINES; RABIES VIRUS; VACCINES, SYNTHETIC; VIRAL PROTEINS; VIRULENCE;

EID: 33645760006     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-005-0006-z     Document Type: Article

References (18)

1. Baloul L, Lafon M (2003) Apoptosis and rabies virus neuroinvasion. Biochimie 85:777-788
2. Blancou J, Meslin F-X (1996) Modified live-virus rabies vaccines for oral immunization of carnivores. In: Meslin F-X, Kaplan MM, Koprowski H (eds) World health organization, laboratory techniques in rabies, 4th edn. World Health Organization, Geneva, pp 324-337
3. Coulon P, Rollin P, Aubert M, Flamand A (1982) Molecular basis of rabies virus virulence. I. Selection of avirulent mutants of the CVS strain with anti-G monoclonal antibodies. J Gen Virol 61:97-100
4. Dietzschold B, Wiktor TJ, Trojanowski JQ, Macfarlan RI, Wunner WH, Torres-Anjel MJ, Koprowski H (1985) Differences in cell-to-cell spread of pathogenic and apathogenic rabies virus in vivo and in vitro. J Virol 56:12-18
5. Dietzschold B, Wunner WH, Wiktor TJ, Lopes AD, Lafon M, Smith CL, Koprowski H (1983) Characterization of an antigenic determinant of the glycoprotein that correlates with pathogenicity of rabies virus. Proc Natl Acad Sci USA 80:70-74
6. Jackson AC (2002) Pathogenesis. In: Jackson AC, Wunner WH (eds) Rabies, Academic Press, San Diego, pp 245-282
7. Jackson AC (2002) Human disease. In: Jackson AC, Wunner WH (eds) Rabies, Academic Press, San Diego, pp 219-244
8. Jackson AC, Ye H, Phelan CC, Ridaura-Sanz C, Zheng Q, Li Z, Wan X, Lopez-Corella E (1999) Extraneural organ involvement in human rabies. Lab Invest 79:945-951
9. Mebatsion T (2001) Extensive attenuation of rabies virus by simultaneously modifying the dynein light chain binding site in the P protein and replacing Arg333 in the G protein. J Virol 75:11496-11502
10. Mori I, Nishiyama Y, Yokochi T, Kimura Y (2004) Virus-induced neuronal apoptosis as pathological and protective responses of the host. Rev Med Virol 14:209-216
11. Morimoto K, Hooper DC, Spitsin S, Koprowski H, Dietzschold B (1999) Pathogenicity of different rabies virus variants inversely correlates with apoptosis and rabies virus glycoprotein expression in infected primary neuron cultures. J Virol 73:510-518
12. Niezgoda M, Hanlon CA, Rupprecht CE (2002) Animal rabies. In: Jackson AC, Wunner WH (eds) Rabies, Academic Press, San Diego, pp 163-218
13. Rasalingam P, Rossiter JP, Jackson AC (2005) Recombinant rabies virus vaccine strain SAD-L16 inoculated intracerebrally in young mice produces a severe encephalitis with extensive neuronal apoptosis. Can J Vet Res 69:100-105
14. Rasalingam P, Rossiter JP, Mebatsion T, Jackson AC (2005) Comparative pathogenesis of the SAD-L16 strain of rabies virus and a mutant modifying the dynein light chain binding site of the rabies virus phosphoprotein in young mice. Virus Res 111:55-60
15. Sarmento L, Li X, Howerth E, Jackson AC, Fu ZF (2005) Glycoprotein-mediated induction of apoptosis limits the spread of attenuated rabies viruses in the central nervous system of mice. J Neurovirol 11:571-581
16. Schneider LG (1995) Rabies virus vaccines. Dev Biol Stand 84:49-54
17. Schnell MJ, Mebatsion T, Conzelmann KK (1994) Infectious rabies viruses from cloned cDNA. EMBO J 13:4195-4203
18. Seif I, Coulon P, Rollin PE, Flamand A (1985) Rabies virulence: Effect on pathogenicity and sequence characterization of rabies virus mutations affecting antigenic site III of the glycoprotein. J Virol 53:926-935