Diagnostic utility of a p63/α-methyl coenzyme A racemase (p504s) cocktail in ambiguous lesions of the prostate upon needle biopsy

BJU International

Volumn 97, Issue 5, 2006, Pages 1109-1115

  Molinié, Vincent ^a   Hervé, Jean Marie ^b   Lugagne, Pierre Marie ^b   Lebret, Thierry ^b   Botto, Henry ^b  

^a SAINT JOSEPH HOSPITAL   (France)

^b FOCH HOSPITAL   (France)

Author keywords

Atypical small acinar proliferation; p504s; p63; Prostatic needle biopsy; Racemase; Small focus carcinoma

Indexed keywords

ALPHA METHYL COENZYME A RACEMASE; ANTIBODY; BIOCHEMICAL MARKER; PROTEIN P63; RACEMASE; UNCLASSIFIED DRUG;

ACINAR CELL; ARTICLE; BASAL CELL; BENIGN TUMOR; CANCER DIAGNOSIS; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE CLASSIFICATION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MALIGNANT NEOPLASTIC DISEASE; NEEDLE BIOPSY; PRIORITY JOURNAL; PROSTATE ADENOMA; PROSTATE CANCER; PROSTATE DISEASE; PROSTATIC INTRAEPITHELIAL NEOPLASIA; PROTEIN EXPRESSION;

ANTIBODIES; BIOPSY, NEEDLE; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE PROTEINS; PROSTATE; PROSTATIC NEOPLASMS; RACEMASES AND EPIMERASES; SENSITIVITY AND SPECIFICITY;

EID: 33645744464     PISSN: 14644096     EISSN: 1464410X     Source Type: Journal    
DOI: 10.1111/j.1464-410X.2006.06069.x     Document Type: Article

References (42)

1. Epstein JI. Diagnosis and reporting of limited adenocarcinoma of the prostate on needle biopsy. Mod Pathol 2004 17 307 15
2. Iczkowski KA Bostwick DG. Criteria for biopsy diagnosis of minimal volume prostatic adenocarcinoma: analytic comparison with nondiagnostic but suspicious atypical small acinar proliferation. Arch Pathol Lab Med 2000 124 98 107
3. Weinstein MH Signoretti S Loda M. Diagnostic utility of immunohistochemical staining for p63, a sensitive marker of prostatic basal cells. Mod Pathol 2002 15 1302 8
4. Srigley JR. Benign mimickers of prostatic adenocarcinoma. Mod Pathol 2004 17 328 48
5. Rubin MA Zhou M Dhanasekaran SM et al. alpha-Methylacyl coenzyme A racemase as a tissue biomarker for prostate cancer. JAMA 2002 287 1662 70
6. Luo J Zha S Gage WR et al. Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer. Cancer Res 2002 62 2220 6
7. Magi-Galluzzi C Luo J Isaacs WB Hicks JL de Marzo AM Epstein JI. Alpha-methylacyl-CoA racemase. a variably sensitive immunohistochemical marker for the diagnosis of small prostate cancer foci on needle biopsy. Am J Surg Pathol 2003 27 1128 33
8. Jiang Z Iczkowski KA Woda BA Tretiakova M Yang XJ. P504S immunostaining boosts diagnostic resolution of 'suspicious' foci in prostatic needle biopsy specimens. Am J Clin Pathol 2004 121 99 107
9. Beach R Gown AM De Peralta-Venturina MN et al. P504S immunohistochemical detection in 405 prostatic specimens including 376 18-gauge needle biopsies. Am J Surg Pathol 2002 26 1588 96
10. Evans AJ. Alpha-methylacyl CoA racemase (P504S): overview and potential uses in diagnostic pathology as applied to prostate needle biopsies. J Clin Pathol 2003 56 892 7
11. Davis LD Zhang W Merseburger A et al. p63 expression profile in normal and malignant prostate epithelial cells. Anticancer Res 2002 22 3819 25
12. Signoretti S Waltregny D Dilks J et al. p63 is a prostate basal cell marker and is required for prostate development. Am J Pathol 2000 157 1769 75
13. Parsons JK Gage WR Nelson WG De Marzo AM. p63 protein expression is rare in prostate adenocarcinoma: implications for cancer diagnosis and carcinogenesis. Urology 2001 58 619 24
14. Xu J Stolk JA Zhang X et al. Identification of differentially expressed genes in human prostate cancer using subtraction and microarray. Cancer Res 2000 60 1677 82
15. Shah RB Zhou M LeBlanc M Snyder M Rubin MA. Comparison of the basal cell-specific markers, 34betaE12 and p63, in the diagnosis of prostate cancer. Am J Surg Pathol 2002 26 1161 8
16. Helpap B Kollermann J Oehler U. Limiting the diagnosis of atypical small glandular proliferations in needle biopsies of the prostate by the use of immunohistochemistry. J Pathol 2001 193 350 3
17. Gown AM Vogel AM. Monoclonal antibodies to human intermediate filament proteins. II. Distribution of filament proteins in normal human tissues. Am J Pathol 1984 114 309 21
18. Varma M Linden MD Amin MB. Effect of formalin fixation and epitope retrieval techniques on antibody 34betaE12 immunostaining of prostatic tissues. Mod Pathol 1999 12 472 8
19. Hedrick L Epstein JI. Use of keratin 903 as an adjunct in the diagnosis of prostate carcinoma. Am J Surg Pathol 1989 13 389 96
20. Abrahams NA Ormsby AH Brainard J. Validation of cytokeratin 5/6 as an effective substitute for keratin 903 in the differentiation of benign from malignant glands in prostate needle biopsies. Histopathology 2002 41 35 41
21. Carella R Deleonardi G D'Errico A et al. Immunohistochemical panels for differentiating epithelial malignant mesothelioma from lung adenocarcinoma: a study with logistic regression analysis. Am J Surg Pathol 2001 25 43 50
22. Chu PG Weiss LM. Keratin expression in human tissues and neoplasms. Histopathology 2002 40 403 39
23. Molinie V Herve JM Lugagne PM Baglin AC. p63 and p504s cocktail is useful in ambiguous lesions of the prostate. Histopathology 2004 44 403 4
24. Molinie V Herve JM Lebret T et al. [Value of the antibody cocktail anti p63+ anti p504s for the diagnosis of prostatic cancer]. Ann Pathol 2004 24 6 16
25. Iczkowski KA Cheng L Crawford BG Bostwick DG. Steam heat with an EDTA buffer and protease digestion optimizes immunohistochemical expression of basal cell-specific antikeratin 34betaE12 to discriminate cancer in prostatic epithelium. Mod Pathol 1999 12 1 4
26. Yang A McKeon F. P63 and P73: P53 mimics, menaces and more. Nat Rev Mol Cell Biol 2000 1 199 207
27. Jiang Z Woda BA Rock KL et al. P504S: a new molecular marker for the detection of prostate carcinoma. Am J Surg Pathol 2001 25 1397 404
28. Amery L Fransen M De Nys K Mannaerts GP Van Veldhoven PP. Mitochondrial and peroxisomal targeting of 2-methylacyl-CoA racemase in humans. J Lipid Res 2000 41 1752 9
29. Schmitz W Albers C Fingerhut R Conzelmann E. Purification and characterization of an alpha-methylacyl-CoA racemase from human liver. Eur J Biochem 1995 231 815 22
30. Jiang Z Fanger GR Woda BA et al. Expression of alpha-methylacyl-CoA racemase (P504s) in various malignant neoplasms and normal tissues: a study of 761 cases. Hum Pathol 2003 34 792 6
31. Tretiakova MS Sahoo S Takahashi M et al. Expression of alpha-methylacyl-CoA racemase in papillary renal cell carcinoma. Am J Surg Pathol 2004 28 69 76
32. Jiang Z Wu CL Woda BA et al. P504S/alpha-methylacyl-CoA racemase: a useful marker for diagnosis of small foci of prostatic carcinoma on needle biopsy. Am J Surg Pathol 2002 26 1169 74
33. Zhou M Chinnaiyan AM Kleer CG Lucas PC Rubin MA. Alpha-Methylacyl-CoA racemase: a novel tumour marker over-expressed in several human cancers and their precursor lesions. Am J Surg Pathol 2002 26 926 31
34. Zhou M Jiang Z Epstein JI. Expression and diagnostic utility of alpha-methylacyl-CoA-racemase (P504S) in foamy gland and pseudohyperplastic prostate cancer. Am J Surg Pathol 2003 27 772 8
35. Schostak M Krause H Köllermann J Schrader M Miller K. Quantitative real-time RT-PCR for AMACR distinguishes prostate cancer with High specificity from benign lesions. J Urol 2005 173 531S (Abstract)
36. Herawi M Parwani AV Irie J Epstein JI. Small glandular proliferations on needle biopsies. Most common benign mimickers of prostatic adenocarcinoma sent in for expert second opinion. Am J Surg Pathol 2005 29 874 80
37. Wu CL Yang XJ Tretiakova M et al. Analysis of alpha-methylacyl-CoA racemase (P504S) expression in high-grade prostatic intraepithelial neoplasia. Hum Pathol 2004 35 1008 13
38. Leav I McNeal JE Ho SM Jiang Z. Alpha-methylacyl-CoA racemase (P504S) expression in evolving carcinomas within benign prostatic hyperplasia and in cancers of the transition zone. Hum Pathol 2003 34 228 33
39. Yang XJ Wu CL Woda BA et al. Expression of alpha-Methylacyl-CoA racemase (P504S) in atypical adenomatous hyperplasia of the prostate. Am J Surg Pathol 2002 26 921 5
40. Luo J Dunn TA Ewing CM Walsh PC Isaacs WB. Decreased gene expression of steroid 5 alpha-reductase 2 in human prostate cancer: implications for finasteride therapy of prostate carcinoma. Prostate 2003 57 134 9
41. Varma M Jasani B. Diagnostic utility of immunohistochemistry in morphologically difficult prostate cancer: review of current literature. Histopathology 2005 47 1 16
42. Hameed O Sublett J Humprey PA. Immunohistochemical stains for p63 and alpha-methylacyl-CoA racemase, versus a cocktail comprising both, in the diagnosis of prostatic carcinoma comparison of the immunohistochemical staining of 430 foci in radical prostatectomy and needle biopsy tissues. Am J Surg Pathol 2005 29 579 87