Impaired antibody affinity maturation process characterizes a subset of patients with common variable immunodeficiency
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Prospective analysis suggests susceptibility genes for deficiencies of IgA and several other immunoglobulins on the [HLA-B8, SC01, DR3] conserved extended haplotype
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Primary defect in CD8+ lymphocytes in the antibody deficiency disease (common variable immunodeficiency): Abnormalities in intracellular production of interferon-gamma (IFN-gamma) in CD28+ ('cytotoxic') and CD28 - (suppressor) CD8+ subsets
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Can HLA-DRB1 typing have prognostic value in patients with undifferentiated chronic arthritis?
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