Computer-aided continuous drug infusion: Setup and test of a mobile closed-loop system for the continuous automated infusion of insulin

IEEE Transactions on Information Technology in Biomedicine

Volumn 10, Issue 2, 2006, Pages 395-402

  Dudde, Ralf ^a   Vering, Thomas ^b   Piechotta, Gundula ^a   Hintsche, Rainer ^a  

^a FRAUNHOFER INSTITUTE FOR SILICON TECHNOLOGY ISIT   (Germany)

^b Disetronic Medical Systems AG   (Switzerland)

Author keywords

Diabetes; Glucose monitor; Insulin infusion

Indexed keywords

ALGORITHMS; CLOSED LOOP CONTROL SYSTEMS; DRUG INFUSION; DRUG PRODUCTS; INSULIN;

DIABETES; GLUCOSE MONITOR; INSULIN INFUSION;

CONTROLLED DRUG DELIVERY;

INSULIN;

ALGORITHM; AMBULATORY CARE; ARTICLE; ARTIFICIAL INTELLIGENCE; BLOOD GLUCOSE MONITORING; COMPUTER ASSISTED DRUG THERAPY; DIABETES MELLITUS; EQUIPMENT; EQUIPMENT DESIGN; FEEDBACK SYSTEM; GLUCOSE BLOOD LEVEL; HUMAN; INSTRUMENTATION; INSULIN INFUSION; METHODOLOGY;

ALGORITHMS; AMBULATORY CARE; ARTIFICIAL INTELLIGENCE; BLOOD GLUCOSE; BLOOD GLUCOSE SELF-MONITORING; DIABETES MELLITUS; DRUG THERAPY, COMPUTER-ASSISTED; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; FEEDBACK; HUMANS; INSULIN; INSULIN INFUSION SYSTEMS;

EID: 33645700078     PISSN: 10897771     EISSN: None     Source Type: Journal    
DOI: 10.1109/TITB.2006.864477     Document Type: Article

References (18)

1. S. Andreassen, E. J. Gomez, and E. R. Carson, "Computers in diabetes 2000," Comput. Meth. Prog. Biomed., vol. 69, pp. 93-95, 2002.
2. E. Colloff, "The promise of technology in the management of the patient with diabetes," Diabetes Technol. Ther., vol. 2, no. 1, pp. 91-99, 2000.
3. D. C. Klonoff, "Welcome to diabetes technology & therapeutics," Diabetes Technol. Ther., vol. 1, no. 1, pp. 1-2, 1999.
4. F. R. Kaufmann, L. C. Gibson, M. Halvorson, S. Carpenter, L. K. Fisher, and P. Pitukcheewanont, "A pilot study of the continuous glucose monitoring system," Diabetes Care, vol. 24, pp. 2030-2034, 2001.
5. A. Maran, C. Crepaldi, A. Tiengo, G. Grassi, E. Vitali, G. Pagano, S. Bistoni, G. Calabrese, F. Santeusanio, F. Leonetti, M. Ribaudo, U. Di Mario, G. Annuzzi, S. Genovese, G. Riccardi, M. Previti, D. Cucinotta, F. Giorgino, A. Bellomo, R. Giorgino, A. Poscia, and M. Varalli, "Continuous subcutaneous glucose monitoring in diabetic patients," Diabetes Care, vol. 25, pp. 347-352, 2002.
6. M. Shichiri, M. Sakakida, K. Nishida, and S. Shimoda, "Enhanced, simplified glucose sensor: Long-term clinical application of wearable artificial endocrine pancreas," Artif. Organs, vol. 22, pp. 32-42, 1998.
7. J. Mastrototar, "The MiniMed continuous glucose monitoring system," J. Pediatr. Endocrinol. Metab., vol. 12, pp. 751-758, 1999.
8. M. J. Tierney, J. A. Tamada, R. O. Potts, L. Jovanovic, and S. Garg, "Clinical evaluation of the GlucoWatch Biographer: A continual, non-invasive glucose monitor for patients with diabetes," Biosens. Bioelectron., vol. 16, pp. 621-629, 2001.
9. E. Wilkens and P. Atanasov, "Glucose monitoring: State of the art," Med. Eng. Phys., vol. 18, pp. 273-288, 1996.
10. K. Jungheim, K. J. Wientjes, I. Heinemann, V. Lodwig, T. Koschinsky, and A. J. Schoonen, "Subcutaneous continuous glucose monitoring," Diabetes Care, vol. 24, pp. 2030-2034, 2001.
11. Z. Trajanoski, G. A. Brunner, L. Schaupp, M. Ellmerer, P. Wach, T. R. Pieber, P. Kotanko, and F. Skrabal, "Open-flow microperfusion of subcutaneous adipose tissue for on-line continuous ex vivo measurement of glucose concentration," Diabetes Care, vol. 20, pp. 1114-1121, 1997.
12. M. Gerritsen, J. A. Jansen, A. Kros, D. M. Vriezema, N. A. J. M. Hövell, and A. van der Gaag, "Influence of inflammatory cells and serum on the performance of implantable glucose sensors," J. Biomed. Mater. Res., vol. 54, pp. 69-75, 2001.
13. R. Hovorka, V. Canonico, L. J. Chassin, U. Haueter, M. Massi-Benedetti, M. Orsini-Federici, T. R. Pieber, H. Schaller, L. Schaupp, T. Vering, and M. E. Wilinska, "Nonlinear model predictive control of glucose concentration in subjects with type 1 diabetes," Physiol. Meas., vol. 25, pp. 905-920, 2004.
14. L. Schaupp, H. Schaller, M. Bodenlenz, B. Balent, J. Plank, R. Sommer, P. Wach, and T. R. Pieber, "Vergleich zwischen S. C. Sensoren und der offenen Mikroperfusionstechnik zur kontinuierlichen Messung der Glukosekonzentration bei Typ 1 Diabetikem," Acta Med. Austriaca Suppl., vol. 55, p. 19, 2001.
15. G. Piechotta, J. Albers, and R. Hintsche, "Novel micromachined silicon sensor for continuous glucose monitoring," Biosens. Bioelectron., vol. 21, pp. 802-808, 2005.
16. R. Bellazi, G. Nucci, and C. Cobelli, "The subcutaneous route to insulin-dependent diabetes therapy," IEEE Eng. Med. Biol. Mag., vol. 20, no. 1, pp. 54-64, Jan./Feb. 2001.
17. L. J. Chassin, U. Haueter, R. Hovorka, M. Massi-Benedetti, M. Orsini-Federici, T. R. Pieber, H. Schaller, L. Schaupp, T. Vering, and M. Wilinska, "Simulating closed loop glucose control: Effect of delay in glucose monitoring," presented at the ADA 62nd Scientific Session, San Francisco, CA, Jun. 2002.
18. H. Schaller, L. Schaupp, M. Bodenlenz, A. Wutte, J. Plank, R. Sommer, H. Zapotoczky, B. Semlitsch, L. J. Chassin, M. E. Wilinska, R. Hovorka, T. Vering, P. Wach, and T. R. Pieber, "Control of blood glucose in patients with type 1 DM with the MPC algorithm under daily life conditions," presented at the 1st Diabetes Technology Meeting, San Francisco, CA, Oct./Nov. 2002