Psychosis among "healthy" siblings of schizophrenia patients

BMC Psychiatry

Volumn 6, Issue , 2006, Pages

  Arajärvi, Ritva ^a   Ukkola, Jonna ^a   Haukka, Jari ^a   Suvisaari, Jaana ^a   Hintikka, Jukka ^c,d   Partonen, Timo ^a   Lönnqvist, Jouko ^a,b  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c PÄIJÄT HÄME CENTRAL HOSPITAL   (Finland)

^d TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; NEUROLEPTIC AGENT; SEDATIVE AGENT;

ADULT; AGED; ANXIETY DISORDER; ARTICLE; BIPOLAR DISORDER; CLINICAL FEATURE; CONTROLLED STUDY; DELUSIONAL DISORDER; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FAMILIAL DISEASE; FEMALE; FINLAND; FOLLOW UP; FREQUENCY ANALYSIS; GENETIC ANALYSIS; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MALE; MEDICAL INFORMATION; MOOD DISORDER; PERSONALITY DISORDER; POPULATION RESEARCH; PSYCHOSIS; RANDOMIZATION; REGISTER; SAMPLING; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SIBLING; COMPARATIVE STUDY; EPIDEMIOLOGY; GENETIC PREDISPOSITION; GENETICS; LONGITUDINAL STUDY; MENTAL DISEASE; METHODOLOGY; MIDDLE AGED; PREVALENCE; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; RISK FACTOR; STATISTICS;

ADULT; AGED; FEMALE; FINLAND; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LONGITUDINAL STUDIES; MALE; MENTAL DISORDERS; MIDDLE AGED; PREVALENCE; PSYCHIATRIC STATUS RATING SCALES; PSYCHOTIC DISORDERS; REGISTRIES; RESEARCH DESIGN; RISK FACTORS; SAMPLING STUDIES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SIBLINGS;

EID: 33645688424     PISSN: 1471244X     EISSN: 1471244X     Source Type: Journal    
DOI: 10.1186/1471-244X-6-6     Document Type: Article

References (35)

1. Kendler KS, McGuire M, Gruenberg AM, O'Hare A, Spellman M, Walsh D: The Roscommon Family Study I. Methods, diagnosis of probands, and risk of schizophrenia in relatives. Arch Gen Psychiatry 1993, 50:527-540.
2. Kendler KS, McGuire M, Gruenberg AM, Spellman M, O'Hare A, Wals D: The Roscommon Family Study, II: the risk of non-schizophrenic nonaffective psychoses in relatives. Arch Gen Psychiatry 1993, 50:645-652.
3. Chang CJ, Chen WJ, Liu SK, Cheng, JJ, Yang WC, Cheng HJ, Lane HY, Lin SK, Yang TW, Hwu HG: Morbidity risk of psychiatric disorders among the first degree relatives of schizophrenia patients in Taiwan. Schizophr Bull 2002, 28:379-392.
4. Austin J: Schizophrenia: An update and review. Genetic Counseling. 2005, 14:329-340.
5. Kendler KS: Kaplan and Sadock's comprehensive Textbook of Psychiatry. In Schizophrenia 7th edition. Edited by: Sadock BJ, Sadock VA, Lippincott, Williams and Wilkins. Philadelphia, PA; 2000:1147-1153.
6. Arajärvi R, Suvisaari J, Suokas J, Schreck M, Haukka J, Hintikka J, Partonen T, Lönnqvist J: Prevalence and diagnosis of schizophrenia based on register, case record and interview data in an isolated Finnish birth cohort born 1940-1969. Soc Psychiatry Psychiatr Epidemiol 2005, 40:808-916.
7. Hovatta I, Terwilliger JD, Lichtermann D, Mäkikyrö T, Suvisaari J, Pelltonen L, Lönnqvist J: Schizophrenia in the genetic isolate of Finland. Am J Med Gen (Neuropsychiatr Gen) 1997, 74:353-360.
8. Hovatta I, Varilo T, Suvisaari J, Terwilliger JD, Ollikainen V, Arajärvi R, Juvonen H, Kokko-Sahin ML, Väisänen L, Mannila H, Lönnqvist J, Peltonen L: A Genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci. Am J Hum Genet 1999, 65:1114-1124.
9. Ekelund J, Hovatta I, Parker A, Paunio T, Varilo T, Martin R, Suhonen J, Ellonen P, Chan G, Sinsheimer J, Sobel E, Juvonen H, Arajärvi R, Partonen T, Suvisaari J, Lönnqvist J, Meyer J, Peltonen L: Chromosome 1 loci in Finnish schizophrenia families. Hum Mol Genet 2001, 15:1611-1617.
10. Ekelund J, Hennah W, Hiekkalinna T, Parker A, Meyer J, Lönnqvist J, Peltonen L: Replication of 1q42 linkage in Finnish schizophrenia pedigrees. Mol Psychiatry 2004, 9:1037-1041.
11. Paunio T, Ekelund J, Varilo T, Parker A, Hovatta I, Turunen JA, Rinard K, Foti A, Terwilliger JD, Juvonen H, Suvisaari J, Arajärvi R, Suokas J, Partonen T, Lönnqvist J, Meyer J, Peltonen L: Genome-wide scan in a nationwide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q. Hum Mol Genet 2001, 26:3037-3048.
12. Paunio T, Tuulio-Henriksson A, Hikkalinna T, Perola M, Varilo T, Partonen T, Cannon TD, Lönnqvist J, Peltonen L: Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q. Hum Mol Genet 2004, 13:1693-1702.
13. Hennah W, Varilo T, Kestilä M, Paunio T, Arajärvi R, Haukka J, Parker A, Martin R, Levitzky S, Partonen T, Meyer J, Lönnqvist J, Peltonen L, Ekelund J: Haplotype transmission analysis provides evidence of association for DISCI to schizophrenia and suggests sex-dependent effects. Hum MolGenet 2003, 12:3151-3159.
14. World Health Organisation: Manual of the International Statistical Classification of Diseases, Injuries and Causes of Death 8th Edition. Geneva 1967.
15. World Health Organization: Manual of the International Statistical Classification of Diseases, Injuries and Causes of Death 9th Edition. Geneva 1977.
16. American Psychiatric Association: Diagnostic and Statistical Manual of mental Disorders, Third Edition-Revised. Washington, DC: American Psychiatric Association; 1987.
17. World Health Organisation: The tenth Revision of the International Statistical Classification of Diseases and Related Health Problems: Diagnostic Criteria for Research. Geneva 1993.
18. Mäkikyrö T, Isohanni M, Moring J, Hakko H, Hovatta I, Lönnqvist J: Accuracy of register-based diagnoses in a genetic study. Eur Psychiatry 1998, 13:57-62.
19. Isohanni M, Mäkikyrö T, Moring J, Räsänen P, Hakko H, Partanen U, Koiranen M, Jones P: A comparison of clinical and research DSM-III-R diagnoses of schizophrenia in Finnish national birth cohort: clinical and research diagnoses of schizophrenia. Soc Psychiatry Psychiatr Epidemiol 1997, 32:303-308.
20. Moilanen K, Veijola J, Läksy K, Mäkikyrö T, Miettunen J, Kantojärvi L, Kokkonen P, Karvonen JT, Herva A, Joukamaa M, Järvelin MR, Moring J, Jones P, Isohanni M: Reasons for the diagnostic discordance between clinicians and researchers in schizophrenia in the Northern Finland 1966 birth cohort. Soc Psychiatry Psychiatr Epidemiol 2003, 38:305-310.
21. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Washington, DC: American Psychiatric Association; 1994.
22. Arajärvi R, Haukka J, Varilo T, Suokas J, Juvonen H, Suvisaari J, Muhonen M, Suominen K, Tuulio-Henriksson A, Schreck M, Hovatta I, Partonen T, Lönnqvist J: Clinical phenotype of schizophrenia in a Finnish isolate. Schizophr Res 2004, 67:195-205.
23. Tuulio-Henriksson A, Arajärvi R, Partionen T, Haukka J, Varilo T, Schreck M, Cannon T, Lönnqvist J: Familial loading associates with impairment in visual span among healthy sibling of schizophrenia patients. Biol Psychiatry 2003, 54:623-628.
24. Aromaa A, Koskinen S: Health and functional capacity in Finland. Helsinki: The National Public Health Institute; 2004.
25. First M, Spitzer R, Gibbon M, Williams J: Structured clinical Interview for DSM-IV axis II disorders (SCID I and II) clinician version. Washington, DC: American Psychiatric Association; 1998.
26. Andreasen NC: The Scale of the Assessment of Negative Symptoms (SANS). Iowa City, IA: University of Iowa; 1983.
27. Williams JB, Gibbon M, First MB, Spitzer RL, Davies M, Borus J, Howes MJ, Kane J, Pope HG, Rounsaville B, Wittchen HU: The Structured Clinical Interview for DSM-III-R (SCID) II. Multisite test-retest reliability. Arch Gen Psychiatry 1992, 49:630-636.
28. Miller PR, Dasher R, Collins R, Griffiths P, Brown F: Inpatient diagnostic assessments: I. Accuracy of structured vs. unstructured interviews. Psychiatr Res 2001, 105:255-264.
29. Zeger SL, Liang KY: Longitudinal data analysis for discrete and continuous outcomes. Biometrics 1986, 42:121-130.
30. Tienari P, Wynne LC, Moring J, Läksy K, Nieminen P, sorri A, lahti I, Wahlber KE, Naarala M, Kurki-Suonio K, saarento O, Koistinen P, Tarvainen T, Hakko H, Miettunen J: Finnish adoptive family study: sample selection and adoptee DSM-III-R diagnoses. Acta Psychiatr Scand 2000, 101:433-443.
31. Maier W, Lichtermann D, Franke P, Heun R, Falkai P, Rietschel M: The dichotomy of schizophrenia and affective disorders in extended pedigrees. Schizophr Res 2002, 57:259-266.
32. Arajärvi P, Varilo T, Haukka J, Suvisaari J, Suokas J, Juvonen H, Muhonen M, Suominen K, Hintikka J, Schreck M, Tuulio-Henriksson AM, Partonen T, Lönnqvist J: Affective flattening and alogia associate with the familial form of schizophrenia. in press.
33. Andreasen NC: The Scale for the Assessment of Negative Symptoms (SANS): Conceptual and Theoretical Foundations. Br J Psychiatry 1989, 155:49-52.
34. Andreasen NC, Arndt S, Alliger R, Miller D, Flaum M: Symptoms of Schizophrenia: Methods, meanings, and mechanisms. Arch Gen Psychiatry 1995, 52:341-351.
35. Norman RMG, Malla AK, Cortese L, Diaz F: A study of the inter-relationship between and comparative interrater reliability of the SAPS, SANS and PANSS. Schizophr Res 1996, 19:73-85.