Brain-specific regulator of G-Protein signaling 9-2 selectively interacts with α-actinin-2 to regulate calcium-dependent inactivation of NMDA receptors

Journal of Neuroscience

Volumn 26, Issue 9, 2006, Pages 2522-2530

  Bouhamdan, Mohamad ^a   Yan, Hai Dun ^a   Yan, Xiu Hua ^a   Bannon, Michael J ^a   Andrade, Rodrigo ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

actinin 2; Calcium dependent inactivation; NMDA receptors; Protein protein interactions; RGS9; RGS9 2; Striatum

Indexed keywords

ALPHA ACTININ; GUANINE NUCLEOTIDE BINDING PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN ALPHA ACTININ 2; PROTEIN G PROTEIN SIGNALING 9 2; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; ACTININ; ACTN2 PROTEIN, HUMAN; CALCIUM; MEMBRANE PROTEIN; N METHYLASPARTIC ACID; NR1 NMDA RECEPTOR; PHOSPHOPROTEIN DARPP 32; POTASSIUM; POTASSIUM CHANNEL; R9AP PROTEIN, HUMAN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DNA LIBRARY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; RAT; SCREENING; ANIMAL; CELL LINE; CELL MEMBRANE POTENTIAL; COMPARATIVE STUDY; DRUG EFFECT; DRUG INTERACTION; ELECTROSTIMULATION; FOREBRAIN; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; MOLECULAR CLONING; NERVE CELL INHIBITION; PATCH CLAMP; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; RADIATION EXPOSURE; TWO HYBRID SYSTEM; WESTERN BLOTTING;

ACTININ; ANIMALS; BLOTTING, WESTERN; CALCIUM; CELL LINE; CLONING, MOLECULAR; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; DRUG INTERACTIONS; ELECTRIC STIMULATION; GENE EXPRESSION REGULATION; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; N-METHYLASPARTATE; NEURAL INHIBITION; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS; PROSENCEPHALON; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 33645642111     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4083-05.2006     Document Type: Article

References (31)

1. Boeckman FA, Aizenman E (1994) Stable transfection of the NR1 subunit in Chinese hamster ovary cells fails to produce a functional N-methyl-Daspartate receptor. Neurosci Lett 173:189-192.
2. Bouhamdan M, Michelhaugh SK, Calin-Jageman I, Ahern-Djamali S, Bannon MJ (2004) Brain-specific RGS9-2 is localized to the nucleus via its unique proline-rich domain. Biochim Biophys Acta 1691:141-150.
3. Chen CK, Eversole-Cire P, Zhang H, Mancino V, Chen YJ, He W, Wensel TG, Simon MI (2003) Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5. Proc Natl Acad Sci USA 100:6604-6609.
4. De Vries L, Zheng B, Fischer T, Elenko E, Farquhar MG (2000) The regulator of G protein signaling family. Annu Rev Pharmacol Toxicol 40:235-271.
5. Drenan RM, Doupnik CA, Boyle MP, Muglia LJ, Huettner JE, Linder ME, Blumer KJ (2005) Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family. J Cell Biol 169:623-633.
6. Dunah AW, Wyszynski M, Martin DM, Sheng M, Standaert DG (2000) α-Actinin-2 in rat striatum: localization and interaction with NMDA glutamate receptor subunits. Brain Res Mol Brain Res 79:77-87.
7. Evans KL, Cropper JD, Berg KA, Clarke WP (2001) Mechanisms of regulation of agonist efficacy at the 5-HT(1A) receptor by phospholipid-derived signaling components. J Pharmacol Exp Ther 297:1025-1035.
8. Gettemans J, Van Impe K, Delanote V, Hubert T, Vandekerckhove J, De Corte V (2005) Nuclear actin-binding proteins as modulators of gene transcription. Traffic 6:847-857.
9. Granneman JG, Zhai Y, Zhu Z, Bannon MJ, Burchett SA, Schmidt CJ, Andrade R, Cooper J (1998) Molecular characterization of human and rat RGS-9L, a novel splice variant enriched in dopamine target regions, and chromosomal localization of the RGS 9 gene. Mol Pharmacol 54:687-694.
10. Harris TJ, Peifer M (2005) Decisions, decisions: beta-catenin chooses between adhesion and transcription. Trends Cell Biol 15:234-237.
11. Hepler JR (2005) R7BP: a surprising new link between G proteins, RGS proteins, and nuclear signaling in the brain. Sci STKE 2005:e38.
12. Hollinger S, Hepler JR (2002) Cellular regulation of RGS proteins: modulators and integrators of G protein signaling. Pharmacol Rev 54:527-559.
13. Kovoor A, Chen CK, He W, Wensel TG, Simon MI, Lester HA (2000) Coexpression of Gbeta5 enhances the function of two Ggamma subunit-like domain-containing regulators of G protein signaling proteins. J Biol Chem 275:3397-3402.
14. 2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways. J Neurosci 25:2157-2165.
15. 2+-dependent inactivation of NMDA receptors. J Neurosci 19:1165-1178.
16. Li Q, Montalbetti N, Shen PY, Dai XQ, Cheeseman CI, Karpinski E, Wu G, Cantiello HF, Chen XZ (2005) Alpha-actinin associates with polycystin-2 and regulates its channel activity. Hum Mol Genet 14:1587-1603.
17. MacArthur DG, North KN (2004) A gene for speed? The evolution and function of alpha-actinin-3. BioEssays 26:786-795.
18. Makino ER, Handy JW, Li T, Arshavsky VY (1999) The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit. Proc Natl Acad Sci USA 96:1947-1952.
19. Martemyanov KA, Yoo PJ, Skiba NP, Arshavsky VY (2005) R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family. J Biol Chem 280:5133-5136.
20. Otey CA, Carpen O (2004) Alpha-actinin revisited: a fresh look at an old player. Cell Motil Cytoskeleton 58:104-111.
21. Ouimet CC, Miller PE, Hemmings Jr HC, Walaas SI, Greengard P (1984) DARPP-32, a dopamine- and adenosine 3′:5′-monophosphate-regulated phosphoprotein enriched in dopamine-innervated brain regions. III. Immunocytochemical localization. J Neurosci 4:111-124.
22. Rahman Z, Gold SJ, Potenza MN, Cowan CW, Ni YG, He W, Wensel TG, Nestler EJ (1999) Cloning and characterization of RGS9-2: a striatal-enriched alternatively spliced product of the RGS9 gene. J Neurosci 19:2016-2026.
23. Rahman Z, Schwarz J, Gold SJ, Zachariou V, Wein MN, Choi KH, Kovoor A, Chen CK, DiLeone RJ, Schwarz SC, Selley DE, Sim-Selley LJ, Barrot M, Luedtke RR, Self D, Neve RL, Lester HA, Simon MI, Nestler EJ (2003) RGS9 modulates dopamine signaling in the basal ganglia. Neuron 38:941-952.
24. + currents. J Biol Chem 274:9899-9904.
25. 2+. Adv Exp Med Biol 514:125-129.
26. Wyszynski M, Lin J, Rao A, Nigh E, Beggs AH, Craig AM, Sheng M (1997) Competitive binding of alpha-actinin and calmodulin to the NMDA receptor. Nature 385:439-442.
27. Wyszynski M, Kharazia V, Shanghvi R, Rao A, Beggs AH, Craig AM, Weinberg R, Sheng M (1998) Differential regional expression and ultrastructural localization of α-actinin-2, a putative NMDA receptor-anchoring protein, in rat brain. J Neurosci 18:1383-1392.
28. Zhang JH, Lai Z, Simonds WF (2000) Differential expression of the G protein beta(5) gene: analysis of mouse brain, peripheral tissues, and cultured cell lines. J Neurochem 75:393-403.
29. Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C, Palczewski K, Wensel TG, Baehr W (1999) Structure, alternative splicing, and expression of the human RGS9 gene. Gene 240:23-34.
30. Zhang S, Ehlers MD, Bernhardt JP, Su CT, Huganir RL (1998) Calmodulin mediates calcium-dependent inactivation of N-methyl-D-aspartate receptors. Neuron 21:443-453.
31. Zhou Q, Ruiz-Lozano P, Martone ME, Chen J (1999) Cypher, a striated muscle-restricted PDZ and LIM domain-containing protein, binds to alpha-actinin-2 and protein kinase C. J Biol Chem 274:19807-19813.