Molecular characterization of human and rat RGS 9L, a novel splice variant enriched in dopamine target regions, and chromosomal localization of the RGS 9 gene

Molecular Pharmacology

Volumn 54, Issue 4, 1998, Pages 687-694

  Granneman, James G ^a,c   Zhai, Ying ^a   Zhu, Zhengxian ^a   Bannon, Michael J ^a   Burchett, Scott A ^a   Schmidt, Carl J ^b   Andrade, Rodrigo ^a   Cooper, James ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Office of the Wayne County Medical Examiner   (United States)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CYCLIC GMP; DOPAMINE 2 RECEPTOR; DOPAMINE RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; RHODOPSIN; TRANSDUCIN;

ANIMAL TISSUE; ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 17Q; DISEASE ASSOCIATION; ENZYME ACTIVITY; GENE EXPRESSION; GENE LOCUS; HUMAN; HUMAN TISSUE; HYPOTHALAMUS; IN SITU HYBRIDIZATION; KIDNEY; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; RAT; REGULATOR GENE; RETINA; RETINITIS PIGMENTOSA; RNA SPLICING; SIGNAL TRANSDUCTION;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DOPAMINE; GENE TARGETING; GTPASE-ACTIVATING PROTEINS; HUMANS; MALE; MOLECULAR SEQUENCE DATA; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SEQUENCE HOMOLOGY, AMINO ACID; TISSUE DISTRIBUTION;

EID: 0031782937     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Acland GM, Ray K, Mellersh CS, Gu W, Langston AA, Rine J, Ostrander EA, and Aguirre GD (1998) Linkage analysis and comparative mapping of canine progressive rod-cone degeneration (prcd) establishes potential locus homology with retinitis pigmentosa (RP 17) in humans. Proc Natl Acad Sci USA 95:3048-3053.
2. Bannon MJ and Whitty CJ (1997) Age-related and regional differences in dopamine transporter mRNA expression in human midbrain. Neurology 48:969-977.
3. Bardien S, Ebenezer N, Greenberg J, Inglehearn CF, Bartman L, Goliath R, Beighton P, Ramesar R, and Bhattacharya SS (1995) An eighth locus for autosomal dominant retinitis pigmentosa is linked to chromosome 17q. Hum Mol Genet 4:1459-1462.
4. Bardien S, Ramesar R, Bhattacharya S, and Greenberg J (1997) Retinitis pigmentosa on 17q (RP 17): fine localization to 17q22 and exclusion of the PDEG and TIMP2 genes. Hum Genet 101:13-17.
5. Berman DM and Gilman AG (1998) Mammalian RGS proteins: barbarians at the gate. J Biol Chem 273:1269-1272.
6. Blackshaw S and Snyder SH (1997) Developmental expression pattern of photo-transduction components in mammalian pineal implies a light-sensing function. J Neurosci 17:8074-8082.
7. Brown BL, Albano JDM, Ekins RP, Sgherzi AM, and Tampion W (1971) A simple and sensitive saturation assay method for the measurement of adenosine 3′:5′-cyclic monophosphate. Biochem J 121:561-562.
8. Burchett SA, Volk ML, Bannon MJ, and Granneman JG (1998) Regulators of G protein signaling: rapid changes in mRNA abundance in response to amphetamine. J Neurochem 70:2216-2219.
9. Chatterjee A, Chakos M, Koreen A, Geisler S, Sheitman B, Woerner M, Kane JM, Alvir J, and Lieberman JA (1995) Prevalence and clinical correlates of extrapyramidal signs and spontaneous dyskinesia in never-medicated schizophrenic patients. Am J Psychiatry 152:1724-1729.
10. Dohlman KG and Thorner J (1997) RGS proteins and signaling by heterotrimeric G proteins. J Biol Chem 272:3871-3874.
11. Dollfus H, Mattei M-G, Rozet J-M, Delrieu O, Munnich A, and Kaplan J (1993) Physical and genetic localization of the gamma subunit of the cyclic GMP phosphodiesterase on the long arm of chromosome 17 (17q25). Genomics 17:526-528.
12. + channels. Proc Natl Acad Sci USA 94:10461-10466.
13. Dryja TP and Li T (1995) Molecular genetics of retinitis pigmentosa. Hum Mol Genet 4:1739-1743.
14. Facrobert E and Hurley JB (1997) The core domain of a new retina specific RGS protein stimulates the GTPase activity of transducin in vitro. Proc Natl Acad Sci USA 94:2945-2950.
15. Gold SJ, Ni YG, Dohlman HG, and Nessler EJ (1997) Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain. J Neurosci 17:8024-8037.
16. 3-adrenergic receptors: involvement of the seventh trans-membrane region in conferring subtype specificity. Mol Pharmacol 53:856-861.
17. 3-adrenergic stimulation. Mol Pharmacol 51:644-650.
18. He W, Cowan CW, and Wesel TG (1998) RGS9, a GTPase accelerator for phototransduction. Neuron 20:95-102.
19. Heng HHQ, Squire J, and Tsui L-C (1992) High resolution mapping of mammalian genes by in situ hybridization to free chromatin. Proc Natl Acad Sci USA 89:9509-9513.
20. Heng HHQ and Tsui L-C (1993) Modes of DAPI banding and simultaneous in situ hybridization. Chromosoma 102:325-332.
21. Huang SH, Pittler SJ, Huang X, Oliveira L, Berson EL, and Dryja TP (1995) Autosomal recessive retinitis pigmentosa caused by mutations in the alpha subunit of rod cGMP phosphodiesterase. Nat Genet 11:468-471.
22. + channels are activated by Gβγ subunits and function as heteromultimers. Proc Natl Acad Sci USA 92:6542-6546.
23. 2 receptors to increase potassium conductance in neurones of the rat substantia nigra zona compacta. J Physiol (Lond) 392:397-416.
24. 2 receptors in rat substantia nigra neurones. J Physiol (Lond) 401:437-453.
25. Le Moine C and Bloch B (1995) D1 and D2 dopamine receptor gene expression in the rat striatum: sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum. J Comp Neurol 355:418-426.
26. Lim WA, Richards FM, and Fox RO (1994) Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains. Nature (Lond) 372:375-379.
27. Linial M (1994) Proline clustering in proteins from synaptic vesicles. Neuroreport 5:2009-2015.
28. McLaughlin ME, Sandberg MA, Berson EL, and Dryja TP (1993) Recessive mutations in the gene encoding the β-subunit of rod phosphodiesterase in patients with retinitis pigmentosa. Nat Genet 4:130-134.
29. Ponting CP and Bork P (1996) Pleckstrin's repeat performance: a novel domain in G-protein signaling? Trends Biochem Sci 21:245-246.
30. Pepperl DJ, Shah-Basu S, VanLeeuwen D, Granneman JG, and MacKenzie RG (1998) Regulation of RGS mRNAs by cAMP in PC12 cells. Biochem Biophys Res Commun 243:52-55.
31. Reuveny E, Slesinger PA, Inglese J, Morales JM, Iniguez-Lluhi JA, Lefkowitz RJ, Bourne HR, Jan YN, and Jan LY (1994) Activation of the cloned muscarinic potassium channel by G protein βγ subunits. Nature (Lond) 370:143-146.
32. Robinson PR, Cohen GB, Zhukovsky EA, and Oprian DD (1992) Constitutively active mutant of rhodopsin. Neuron 9:719-725.
33. Rosenfeld PJ, Crowley GS, McGee TL, Sandberg MA, Berson EL, and Dryja TP (1992). A null mutation in the rhodopsin gene causes rod photoreceptor dysfunction and autosomal recessive retinitis pigmentosa. Nat Genet 1:209-213.
34. + currents. Nature (Lond) 390:525-529.
35. Sambrook JE, Fritsch EF, and Maniatis T (1989) Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Labs, Cold Spring Harbor, NY.
36. Staub O and Rotlin D (1996) WW domains. Structure 4:495-499.
37. Tesmer JJ, Berman DM, Gilman AG, and Sprang SR (1997) Structure of RGS4 bound to AIF4-activated Giα: stabilization of the transition state for GTP hydrolysis. Cell 89:251-261.
38. Thomas EA, Danielson PE, and Sutcliffe JG (1998) RGS9: a regulator of G-protein signalling with specific expression in the rat and mouse striatum. J Neurosci Res 52:118-124.
39. Tsang, SH, Gouras P, Yamashita CK, Kjeldbye H, Fisher J, Farber DB, and Goff SP (1996) Retinal degeneration in mice lacking the γ subunit of the rod cGMP phosphodiesterase. Science (Washington D C) 272:1026-1029.
40. Tuteja N, Danciger M, Klisak I. Tuteja R, Inana G, Mohandas T, Sparkes RS, and Farber DB (1990) Isolation and characterization of the cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina. Gene 88:227-232.
41. Watson N, Linder ME, Druey KM, Kerl JH, and Blumer KJ (1996) RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits. Nature (Lond) 383:172-175.
42. Wszolek ZK, Pfeiffer RF, Bhatt MH, Schelper RL, Cordes M, Snow BJ, Rodnitzky RL, Wolters EC, Arwert F, and Calne DB (1992) Rapidly progressive autosomal dominant parkinsonism and dementia with pallido-ponto-nigral degeneration. Ann Neurol 32:312-320.