The Behind-the-Knee test: An efficient model for evaluating mechanical and chemical irritation

Skin Research and Technology

Volumn 12, Issue 2, 2006, Pages 73-82

  Farage, Miranda A ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Behind the knee test system; BTK test system; Catamenial products; Feminine hygiene products; Mechanical irritation; Popliteal fossa test; Skin irritation

Indexed keywords

BIOLOGICAL MATERIALS; MATERIALS TESTING; MATHEMATICAL MODELS;

BEHIND THE KNEE TEST SYSTEM; CATAMENIAL PRODUCTS; FEMININE HYGIENE PRODUCTS; MECHANICAL IRRITATION; POPLITEAL FOSSA TEST; SKIN IRRITATION;

BIOMEDICAL ENGINEERING;

CHEMICAL INJURY; CONTROLLED STUDY; COST CONTROL; DIAPER; FEMALE; FRICTION; HUMAN; HUMAN EXPERIMENT; INTERMETHOD COMPARISON; LAUNDRY; MALE; MECHANICAL STIMULATION; NORMAL HUMAN; PATCH TEST; RELIABILITY; REPRODUCIBILITY; REVIEW; SCORING SYSTEM; SKIN IRRITATION; SKIN TEST; TEXTILE; TIME MANAGEMENT;

ABSORBENT PADS; BIOCOMPATIBLE MATERIALS; BIOMECHANICS; DERMATITIS, IRRITANT; HUMANS; MENSTRUAL HYGIENE PRODUCTS; PATCH TESTS; PHYSICAL STIMULATION; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SKIN IRRITANCY TESTS;

EID: 33645579450     PISSN: 0909752X     EISSN: 16000846     Source Type: Journal    
DOI: 10.1111/j.0909-752X.2006.00184.x     Document Type: Review

References (18)

1. Bannan EA, Griffith JF, Nusair TL, Sauers LJ. Skin testing of laundered fabrics in the dermal safety assessment of enzyme-containing detergents. J Toxicol Cutan Ocular Toxicol 1992; 11: 327-339.
2. Rodriguez C, Calvin G, Lally C, LaChapelle JM. Skin effects associated with wearing fabrics washed with commercial laundry detergents. J Toxicol Cutan Ocular Toxicol 1994; 13: 39-45.
3. Ertel KD, Keswick BH, Bryant PB. A forearm controlled application technique for estimating the relative mildness of personal cleansing products. J Soc Cosmet Chem 1995; 46: 67-76.
4. Strube DD, Koontz SW, Murahata RI, Theiler RF. The flex wash method: A method for evaluating the mildness of personal washing products. J Soc Cosmet Chem 1989; 40: 297-306.
5. Lukacovic MF, Dunlap FE, Michaels SE, Visscher VO, Watson DD. Forearm wash test to evaluate the clinical mildness of cleansing products. J Soc Cosmet Chem 1988; 39: 355-366.
6. Farage MA. Development of a modified forearm controlled application test method for evaluating the skin mildness of disposable wipe products. J Cosmet Sci 2000; 51: 153-167.
7. Farage-Elawar MA, Enane NA, Baldwin S, Sarbaugh FC, Bergholz C, Berg RW. A clinical method for testing the safety of catamenial pads. Gynecol Obstet Invest 1997; 44: 260-264.
8. Elsner P, Wilhelm D, Maibach HI. Friction properties of human forearm and vulvar skin: Influence of age and correlation with transepidermal water loss and capacitance. Dermatologica 1990; 181: 88-91.
9. Farage MA. Development of a new mechanical irritation test. Toxicologist 2000; 54: 203.
10. Farage MA, Gilpin DA, Enane NA, Baldwin S. Development of a new test for mechanical irritation: Behind the knee as a test site. Skin Res Technol 2001; 7: 193-203.
11. Farage MA, Meyer S, Walter D. Development of a sensitive test method to evaluate mechanical irritation potential on mucosal skin. Skin Res Technol 2004; 10: 85-95.
12. Farage MA, Meyer SJ, Walter D. Evaluation of modifications of the traditional patch test in assessing the chemical irritation potential of feminine hygiene products. Skin Res Technol 2004; 10: 73-84.
13. Farage MA, Stadler A, Elsner P, Maibach HI. Safety evaluation of modern hygiene pads: Two decades of use. Female Patient 2004; 29: 23-30.
14. Langley R. Wilcoxon's signed ranks test. In: Langley R, ed. Practical statistics simply explained. New York: Dover Publications Inc., 1970: 179-189.
15. Mehta CR, Patel NR. A network algorithm for performing Fisher's Exact Test in rXc contingency tables. J Am Statist Asso 1983; 78: 427-434.
16. Agresti AC. Categorical data analysis. New York: John Wiley & Sons, 1990.
17. Montgomery DC. Design and analysis of experiments. New York: John Wiley & Sons, 1984.
18. Farage MA, Santana MV, Henley E. Correlating sensory effects with irritation. J Toxicol Cutan Ocular Toxicol 2005; 24: 1-8.