Synthesis and in vitro evaluation of iodinated derivatives of piperazine as a new ligand for sigma receptor imaging by single photon emission computed tomography

Chemical and Pharmaceutical Bulletin

Volumn 54, Issue 4, 2006, Pages 470-475

  Hirata, Masahiko ^a   Mori, Tetsuya ^a   Soga, Seigo ^a   Umeda, Takuya ^a   Ohmomo, Yoshiro ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

Piperazine; Radioiodine; Radiopharmaceutical; SA4503; Sigma receptor; Single photon emission computed tomography (SPECT)

Indexed keywords

1 (3,4 DIMETHOXYPHENETHYL) 4 (3 PHENYLPROPYL)PIPERAZINE; 1,3 DI O TOLYLGUANIDINE H3; ATROPINE; GUANIDINE DERIVATIVE; HALOPERIDOL; IODINE 125; IODOPIPERAZINE DERIVATIVE; N ALLYLNORMETAZOCINE; NALOXONE; NICOTINE; PENTAZOCINE; PENTOXYVERINE; PHENTOLAMINE; PIPERAZINE DERIVATIVE; PRECLAMOL; PROPRANOLOL; RADIOLIGAND; RIMCAZOLE; SIGMA OPIATE RECEPTOR; SPIPERONE; SULPIRIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; ISOTOPE LABELING; NONHUMAN; RADIOIODINATION; RAT; RECEPTOR AFFINITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; BRAIN; CYCLOPENTANES; IODINE RADIOISOTOPES; LIGANDS; PENTAZOCINE; PIPERAZINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, SIGMA; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TRIALKYLTIN COMPOUNDS;

EID: 33645544409     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.54.470     Document Type: Article

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