-
1
-
-
0035048096
-
Cytokine therapy for metastatic renal cell carcinoma
-
Bukowski RM: Cytokine therapy for metastatic renal cell carcinoma. Semin Urol Oncol 2001, 19:148-154.
-
(2001)
Semin Urol Oncol
, vol.19
, pp. 148-154
-
-
Bukowski, R.M.1
-
2
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
Gnarra JR, Tory K, Weng Y, et al.: Mutations of the VHL tumour suppressor gene in renal carcinoma. Nat Genet 1994, 7:85-90.
-
(1994)
Nat Genet
, vol.7
, pp. 85-90
-
-
Gnarra, J.R.1
Tory, K.2
Weng, Y.3
-
3
-
-
0028235907
-
Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas
-
Shuin T, Kondo K, Torigoe S, et al.: Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res 1994, 54:2852-2855.
-
(1994)
Cancer Res
, vol.54
, pp. 2852-2855
-
-
Shuin, T.1
Kondo, K.2
Torigoe, S.3
-
4
-
-
0028072991
-
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
-
Herman JG, Latif F, Weng Y, et al.: Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci U S A 1994, 91:9700-9704.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 9700-9704
-
-
Herman, J.G.1
Latif, F.2
Weng, Y.3
-
5
-
-
0028897420
-
Genetics of renal-cell carcinoma and evidence for a critical role for von Hippel-Lindau in renal tumorigenesis
-
Gnarra JR, Lerman MI, Zbar B, Linehan WM: Genetics of renal-cell carcinoma and evidence for a critical role for von Hippel-Lindau in renal tumorigenesis. Semin Oncol 1995, 22:3-8.
-
(1995)
Semin Oncol
, vol.22
, pp. 3-8
-
-
Gnarra, J.R.1
Lerman, M.I.2
Zbar, B.3
Linehan, W.M.4
-
6
-
-
0036176874
-
Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity
-
Hansen WJ, Ohh M, Moslehi J, et al.: Diverse effects of mutations in exon II of the von Hippel-Lindau (VHL) tumor suppressor gene on the interaction of pVHL with the cytosolic chaperonin and pVHL-dependent ubiquitin ligase activity. Mol Cell Biol 2002, 22:1947-1960.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 1947-1960
-
-
Hansen, W.J.1
Ohh, M.2
Moslehi, J.3
-
7
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin DJ, Ellis LM: Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005, 23:1011-1027.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
8
-
-
0029004025
-
Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
-
Dvorak HF, Brown LF, Detmar M, Dvorak AM: Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995, 146:1029-1039.
-
(1995)
Am J Pathol
, vol.146
, pp. 1029-1039
-
-
Dvorak, H.F.1
Brown, L.F.2
Detmar, M.3
Dvorak, A.M.4
-
9
-
-
0031039243
-
The biology of vascular endothelial growth factor
-
Ferrara N, Davis-Smyth T: The biology of vascular endothelial growth factor. Endocr Rev 1997, 18:4-25.
-
(1997)
Endocr Rev
, vol.18
, pp. 4-25
-
-
Ferrara, N.1
Davis-Smyth, T.2
-
10
-
-
0032952010
-
Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
-
Benjamin LE, Golijanin D, Itin A, et al.: Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. J Clin Invest 1999, 103:159-165.
-
(1999)
J Clin Invest
, vol.103
, pp. 159-165
-
-
Benjamin, L.E.1
Golijanin, D.2
Itin, A.3
-
11
-
-
0032169018
-
Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor
-
Jain RK, Safabakhsh N, Sckell A, et al.: Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor. Proc Natl Acad Sci USA 1998, 95:10820-10825.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 10820-10825
-
-
Jain, R.K.1
Safabakhsh, N.2
Sckell, A.3
-
12
-
-
0030999445
-
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells
-
Watanabe Y, Lee SW, Detmar M, et al.: Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells. Oncogene 1997, 14:2025-2032.
-
(1997)
Oncogene
, vol.14
, pp. 2025-2032
-
-
Watanabe, Y.1
Lee, S.W.2
Detmar, M.3
-
13
-
-
0032547385
-
Signal transduction via platelet-derived growth factor receptors
-
Heldin CH, Ostman A, Ronnstrand L: Signal transduction via platelet-derived growth factor receptors. Biochim Biophys Acta 1998, 1378:F79-F113.
-
(1998)
Biochim. Biophys Acta
, vol.1378
-
-
Heldin, C.H.1
Ostman, A.2
Ronnstrand, L.3
-
14
-
-
0031964099
-
Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor
-
Knebelmann B, Ananth S, Cohen HT, Sukhatme VP: Transforming growth factor alpha is a target for the von Hippel-Lindau tumor suppressor. Cancer Res 1998, 58:226-231.
-
(1998)
Cancer Res
, vol.58
, pp. 226-231
-
-
Knebelmann, B.1
Ananth, S.2
Cohen, H.T.3
Sukhatme, V.P.4
-
15
-
-
0035852630
-
Role of transforming growth factor-alpha in von Hippel-Lindau (VHL) (-/-) clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis
-
de Paulsen N, Brychzy A, Fournier MC, et al.: Role of transforming growth factor-alpha in von Hippel-Lindau (VHL) (-/-) clear cell renal carcinoma cell proliferation: A possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proc Natl Acad Sci U S A 2001, 98:1387-1392.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 1387-1392
-
-
de Paulsen, N.1
Brychzy, A.2
Fournier, M.C.3
-
16
-
-
0242581718
-
Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells
-
Gunaratnam L, Morley M, Franovic A, et al.: Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells. J Biol Chem 2003, 278:44966-44974.
-
(2003)
J Biol Chem
, vol.278
, pp. 44966-44974
-
-
Gunaratnam, L.1
Morley, M.2
Franovic, A.3
-
17
-
-
0030856731
-
Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
-
Presta LG, Chen H, O'Connor SJ, et al.: Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res 1997, 57:4593-4599.
-
(1997)
Cancer Res
, vol.57
, pp. 4593-4599
-
-
Presta, L.G.1
Chen, H.2
O'Connor, S.J.3
-
18
-
-
0042343801
-
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
-
Yang JC, Haworth L, Sherry RM, et al.: A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med, 2003, 349:427-434.
-
(2003)
N Engl J Med
, vol.349
, pp. 427-434
-
-
Yang, J.C.1
Haworth, L.2
Sherry, R.M.3
-
19
-
-
4644229716
-
Bevacizumab for patients with metastatic renal cancer: An update
-
Yang JC: Bevacizumab for patients with metastatic renal cancer: An update. Clin Cancer Res 2004, 10:6367S-6370S.
-
(2004)
Clin Cancer Res
, vol.10
-
-
Yang, J.C.1
-
20
-
-
1942470411
-
Cancer and Leukemia Group B 90206: A randomized phase III trial of interferon-alpha or interferon-alpha plus anti-vascular endothelial growth factor antibody (bevacizumab) in metastatic renal cell carcinoma
-
Rini BI, Halabi S, Taylor J, et al.: Cancer and Leukemia Group B 90206: A randomized phase III trial of interferon-alpha or interferon-alpha plus anti-vascular endothelial growth factor antibody (bevacizumab) in metastatic renal cell carcinoma. Clin Cancer Res 2004, 10:2584-2586.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 2584-2586
-
-
Rini, B.I.1
Halabi, S.2
Taylor, J.3
-
21
-
-
0037468875
-
Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase
-
Sun L, Liang C, Shirazian S, et al.: Discovery of 5-[5-fluoro-2-oxo-1,2- dihydroindol-(3Z)-ylidenemethyl]-2,4- dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase. J Med Chem 2003, 46:1116-1119.
-
(2003)
J Med Chem
, vol.46
, pp. 1116-1119
-
-
Sun, L.1
Liang, C.2
Shirazian, S.3
-
22
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
-
Mendel DB, Laird AD, Xin X, et al.: In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003, 9:327-337.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
-
23
-
-
23844480013
-
Phase 2 trials of SU11248 show antitumor activity in second-line therapy for patients with metastatic renal cell carcinoma (RCC)
-
Motzer RJ, Rini BI, Michaelson MD, et al.: Phase 2 trials of SU11248 show antitumor activity in second-line therapy for patients with metastatic renal cell carcinoma (RCC). Proc ASCO 2005, 23(16S):4508.
-
(2005)
Proc ASCO
, vol.23
, Issue.16 S
, pp. 4508
-
-
Motzer, R.J.1
Rini, B.I.2
Michaelson, M.D.3
-
24
-
-
0034784725
-
Discovery of a novel Raf kinase inhibitor
-
Lyons JF, Wilhelm S, Hibner B, Bollag G: Discovery of a novel Raf kinase inhibitor. Endocr Relat Cancer, 2001, 8:219-225.
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 219-225
-
-
Lyons, J.F.1
Wilhelm, S.2
Hibner, B.3
Bollag, G.4
-
25
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, et al.: BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res, 2004, 64:7099-7109.
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
26
-
-
23844455555
-
Final findings from a Phase II, placebo-controlled, randomized discontinuation trial (RDT) of sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC)
-
[abstract]
-
Ratain MJ, Eisen T, Stadler WM, et al.: Final findings from a Phase II, placebo-controlled, randomized discontinuation trial (RDT) of sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC) [abstract]. Proc ASCO 2005, 23(16S):4544.
-
(2005)
Proc ASCO
, vol.23
, Issue.16 S
, pp. 4544
-
-
Ratain, M.J.1
Eisen, T.2
Stadler, W.M.3
-
27
-
-
23844558595
-
Randomized Phase III trial of the Raf kinase and VEGFR inhibitor sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC)
-
[abstract]
-
Escudier B, Szczylik C, Eisen T, et al.: Randomized Phase III trial of the Raf kinase and VEGFR inhibitor sorafenib (BAY 43-9006) in patients with advanced renal cell carcinoma (RCC) [abstract]. Proc ASCO 2005, 23(16S):4510.
-
(2005)
Proc ASCO
, vol.23
, Issue.16 S
, pp. 4510
-
-
Escudier, B.1
Szczylik, C.2
Eisen, T.3
-
28
-
-
3042548695
-
Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
-
Inai T, Mancuso M, Hashizume H, et al.: Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol 2004, 165:35-52.
-
(2004)
Am J Pathol
, vol.165
, pp. 35-52
-
-
Inai, T.1
Mancuso, M.2
Hashizume, H.3
-
29
-
-
23844446510
-
AG-013736, a multi-target tyrosine kinase receptor inhibitor, demonstrates anti-tumor activity in a Phase 2 study of cytokine-refractory, metastatic renal cell cancer (RCC)
-
[abstract]
-
Rini B, Rixe O, Bukowski R, et al.: AG-013736, a multi-target tyrosine kinase receptor inhibitor, demonstrates anti-tumor activity in a Phase 2 study of cytokine-refractory, metastatic renal cell cancer (RCC) [abstract]. Proc ASCO 2005, 23(16S):4509.
-
(2005)
Proc ASCO
, vol.23
, Issue.16 S
, pp. 4509
-
-
Rini, B.1
Rixe, O.2
Bukowski, R.3
-
30
-
-
12444251187
-
Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma
-
Motzer RJ, Amato R, Todd M, et al.: Phase II trial of antiepidermal growth factor receptor antibody C225 in patients with advanced renal cell carcinoma. Invest New Drugs 2003, 21:99-101.
-
(2003)
Invest New Drugs
, vol.21
, pp. 99-101
-
-
Motzer, R.J.1
Amato, R.2
Todd, M.3
-
31
-
-
0345714775
-
Phase II trial of ZD1839 (IRESSA) in patients with advanced renal cell carcinoma
-
Drucker B, Bacik J, Ginsberg M, et al.: Phase II trial of ZD1839 (IRESSA) in patients with advanced renal cell carcinoma. Invest New Drugs 2003, 21:341-345.
-
(2003)
Invest New Drugs
, vol.21
, pp. 341-345
-
-
Drucker, B.1
Bacik, J.2
Ginsberg, M.3
-
32
-
-
9744240281
-
A phase II trial of gefitinib (Iressa, ZD1839) in stage IV and recurrent renal cell carcinoma
-
Dawson NA, Guo C, Zak R, et al.: A phase II trial of gefitinib (Iressa, ZD1839) in stage IV and recurrent renal cell carcinoma. Clin Cancer Res 2004, 10:7812-7819.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 7812-7819
-
-
Dawson, N.A.1
Guo, C.2
Zak, R.3
-
33
-
-
0035394833
-
Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: A role for altered tumor angiogenesis
-
Viloria-Petit A, Crombet T, Jothy S, et al.: Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: A role for altered tumor angiogenesis. Cancer Res, 2001, 61:5090-5101.
-
(2001)
Cancer Res
, vol.61
, pp. 5090-5101
-
-
Viloria-Petit, A.1
Crombet, T.2
Jothy, S.3
-
34
-
-
21344437413
-
Bevacizumab and erlotinib in the treatment of patients with metastatic renal carcinoma (RCC): Update of a phase II multicenter trial
-
[abstract]
-
Spigel DR, Hainsworth JD, Sosman JA, et al.: Bevacizumab and erlotinib in the treatment of patients with metastatic renal carcinoma (RCC): Update of a phase II multicenter trial [abstract]. Proc ASCO 2005, 23 (16S):4540.
-
(2005)
Proc ASCO
, vol.23
, Issue.16 S
, pp. 4540
-
-
Spigel, D.R.1
Hainsworth, J.D.2
Sosman, J.A.3
-
35
-
-
0033514050
-
Interferon-alpha and survival in metastatic renal carcinoma: Early results of a randomised controlled trial
-
Medical Research Council Renal Cancer Collaborators
-
Medical Research Council Renal Cancer Collaborators: Interferon-alpha and survival in metastatic renal carcinoma: Early results of a randomised controlled trial. Lancet 1999, 353:14-17.
-
(1999)
Lancet
, vol.353
, pp. 14-17
-
-
-
36
-
-
0029812542
-
Long-term response data for 255 patients with metastatic renal cell carcinoma treated with high-dose recombinant interleukin-2 therapy
-
Fyfe GA, Fisher RI, Rosenberg SA, et al.: Long-term response data for 255 patients with metastatic renal cell carcinoma treated with high-dose recombinant interleukin-2 therapy. J Clin Oncol 1996, 14:2410-2411.
-
(1996)
J Clin Oncol
, vol.14
, pp. 2410-2411
-
-
Fyfe, G.A.1
Fisher, R.I.2
Rosenberg, S.A.3
-
37
-
-
2442737061
-
Prospective randomized trial of interferon alfa-2a plus vinblastine versus vinblastine alone in patients with advanced renal cell cancer
-
Pyrhonen S, Salminen E, Ruutu M, et al.: Prospective randomized trial of interferon alfa-2a plus vinblastine versus vinblastine alone in patients with advanced renal cell cancer. J Clin Oncol, 1999, 17:2859-2867.
-
(1999)
J Clin Oncol
, vol.17
, pp. 2859-2867
-
-
Pyrhonen, S.1
Salminen, E.2
Ruutu, M.3
|