Autocrine growth hormone prevents lactogenic differentiation of mouse mammary epithelial cells

Endocrinology

Volumn 147, Issue 4, 2006, Pages 1819-1829

  Mukhina, Svetlana ^a,d   Liu, DongXu ^c   Guo, Ke ^a   Raccurt, Mireille ^b   Borges Bendris, Sahra ^b   Mertani, Hichem C ^b   Lobie, Peter E ^c  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b CNRS   (France)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CASEIN; BROXURIDINE; GROWTH HORMONE; MATRIGEL; UVOMORULIN;

ANIMAL EXPERIMENT; ARTICLE; AUTOCRINE EFFECT; BREAST EPITHELIUM; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; FEMALE; GENETIC TRANSFECTION; HORMONE RELEASE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LACTATION; MILK PRODUCTION; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PUBERTY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; STATISTICAL ANALYSIS;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; EPITHELIAL CELLS; FEMALE; GROWTH HORMONE; MALE; MAMMARY GLANDS, ANIMAL; MICE; MORPHOGENESIS; RECEPTORS, SOMATOTROPIN; RNA, MESSENGER;

EID: 33645524739     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2005-1082     Document Type: Article

References (62)

1. Hennighausen L, Robinson GW 1998 Think globally, act locally: the making of a mouse mammary gland. Genes Dev 12:449-455
2. Silberstein GB 2001 Postnatal mammary gland morphogenesis. Microsc Res Tech 52:155-162
3. Neville MC, McFadden TB, Forsyth I 2002 Hormonal regulation of mammary differentiation and milk secretion. J Mammary Gland Biol Neoplasia 7:49-66
4. Strange R, Li F, Saurer S, Burkhardt A, Friis RR 1992 Apoptotic cell death and tissue remodelling during mouse mammary gland involution. Development 115:49-58
5. Ruan W, Newman CB, Kleinberg DL 1992 Intact and amino-terminally shortened forms of insulin-like growth factor I induce mammary gland differentiation and development. Proc Natl Acad Sci USA 89:10872-10976
6. Feldman M, Ruan W, Cunningham BC, Wells JA, Kleinberg DL 1993 Evidence that the growth hormone receptor mediates differentiation and development of the mammary gland. Endocrinology 133:1602-1608
7. Walden PD, Ruan W, Feldman M, Kleinberg DL 1998 Evidence that the mammary fat pad mediates the action of growth hormone in mammary gland development. Endocrinology 139:659-662
8. Ruan W, Kleinberg DL 1999 Insulin-like growth factor I is essential for terminal end bud formation and ductal morphogenesis during mammary development. Endocrinology 140:5075-5081
9. Kleinberg DL 1997 Early mammary development: growth hormone and IGF-1. J Mammary Gland Biol Neoplasia 2:49-57
10. Kleinberg DL, Feldman M, Ruan W 2000 IGF-I: an essential factor in terminal end bud formation and ductal morphogenesis. J Mammary Gland Biol Neoplasia 5:7-17
11. Gallego MI, Binart N, Robinson GW, Okagaki R, Coschigano KT, Perry J, Kopchick JJ, Oka T, Kelly PA, Hennighausen L 2001 Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects. Dev Biol 229:163-175
12. Allan GJ, Tonner E, Barber MC, Travers MT, Shand JH, Vernon RG, Kelly PA, Binart N, Flint DJ 2002 Growth hormone, acting in part through the insulin-like growth factor axis, rescues developmental, but not metabolic, activity in the mammary gland of mice expressing a single allele of the prolactin receptor. Endocrinology 143:4310-4319
13. Madon RJ, Ensor DM, Knight CH, Flint DJ 1986 Effects of an antiserum to rat growth hormone on lactation in the rat. J Endocrinol 111:117-123
14. Caron RW, Jahn GA, Deis RP 1994 Lactogenic actions of different growth hormone preparations in pregnant and lactating rats. J Endocrinol 142:535-545
15. Flint DJ, Gardner M 1994 Evidence that growth hormone stimulates milk synthesis by direct action on the mammary gland and that prolactin exerts effects on milk secretion by maintenance of mammary deoxyribonucleic acid content and tight junction status. Endocrinology 135:1119-1124
16. Markoff E, Talamantes F 1980 The lactogenic response of mouse mammary explants to mouse prolactin and growth hormone. Endocr Res Commun7:269-278
17. Thordarson G, Villalobos R, Colosi P, Southard J, Ogren L, Talamantes F 1986 Lactogenic response of cultured mouse mammary epithelial cells to mouse placental lactogen. J Endocrinol 109:263-274
18. van Garderen E, de Wit M, Voorhout WF, Rutteman GR, Mol JA, Nederbragt H, Misdorp W 1997 Expression of growth hormone in canine mammary tissue and mammary tumors. Evidence for a potential autocrine/paracrine stimulatory loop. Am J Pathol 150:1037-1047
19. Mol JA, Lantinga-van Leeuwen I, van Garderen E, Rijnberk A 2000 Progestin-induced mammary growth hormone (GH) production. Adv Exp Med Biol 480:71-76
20. Mol JA, van Garderen E, Rutterman GR, Rijnberk A 1996 New insights in the molecular mechanism of progestin-induced proliferation of mammary epithelium: induction of the local biosynthesis of growth hormone (GH) in the mammary glands of dogs, cats and humans. J Steroid Biochem Mol Biol 57:67-71
21. Raccurt M, Lobie PE, Moudilou E, Garcia-Caballero T, Frappart L, Morel G, Mertani HC 2002 High stromal and epithelial human GH gene expression is associated with proliferative disorders of the mammary gland. J Endocrinol 175:307-318
22. Xu XQ, Emerald BS, Goh EL, Kannan N, Miller LD, Gluckman PD, Liu ET, Lobie PE 2005 Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma. J Biol Chem 280:23987-24003
23. Zhu T, Starling-Emerald B, Zhang X, Lee KO, Gluckman PD, Mertani HC, Lobie PE 2005 Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormone. Cancer Res 65:317-324
24. Mukhina S, Mertani HC, Guo K, Lee KO, Gluckman PD, Lobie PE 2004 Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone. Proc Natl Acad Sci USA 101:15166-15171
25. Pantaleon M, Whiteside EJ, Harvey MB, Barnard RT, Waters MJ, Kaye PL 1997 Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis? Proc Natl Acad Sci USA 94:5125-5130
26. Szepeshazi K, Schally AV, Armatis P, Groot K, Hebert F, Feil A, Varga JL, Halmos G 2001 Antagonists of GHRH decrease production of GH and IGF-I in MXT mouse mammary cancers and inhibit tumor growth. Endocrinology 142:4371-4378
27. Linzer DI, Talamantes F 1985 Nucleotide sequence of mouse prolactin and growth hormone mRNAs and expression of these mRNAs during pregnancy. J Biol Chem 260:9574-9579
28. Raccurt M, Tam SP, Lau P, Mertani HC, Lambert A, Garcia-Caballero T, Li H, Brown RJ, McGuckin MA, Morel G, Waters MJ 2003 Suppressor of cytokine signalling gene expression is elevated in breast carcinoma. Br J Cancer 89:524-532
29. Deugnier MA, Faraldo MM, Rousselle P, Thiery JP, Glukhova MA 1999 Cell-extracellular matrix interactions and EGF are important regulators of the basal mammary epithelial cell phenotype. J Cell Sci 112:1035-1044
30. Mertani HC, Garcia-Caballero T, Lambert A, Gerard F, Palayer C, Boutin JM, Vonderhaar BK, Waters MJ, Lobie PE, Morel G 1998 Cellular expression of growth hormone and prolactin receptors in human breast disorders. Int J Cancer 79:202-211
31. Niranjan B, Buluwela L, Yant J, Perusinghe N, Atherton A, Phippard D, Dale T, Gusterson B, Kamalati T 1995 HGF/SF: a potent cytokine for mammary growth, morphogenesis and development. Development 121:2897-2908
32. Mertani HC, Raccurt M, Abbate A, Kindblom J, Tornell J, Billestrup N, Usson Y, Morel G, Lobie PE 2003 Nuclear translocation and retention of growth hormone. Endocrinology 144:3182-3195
33. Danielson KG, Oborn CJ, Durban EM, Butel JS, Medina D 1984 Epithelial mouse mammary cell line exhibiting normal morphogenesis in vivo and functional differentiation in vitro. Proc Natl Acad Sci USA 81:3756-3760
34. Ball RK, Friis RR, Schoenenberger CA, Doppler W, Groner B 1988 Prolactin regulation of β-casein gene expression and of a cytosolic 120-kd protein in a cloned mouse mammary epithelial cell line. EMBO J 7:2089-2095
35. Hynes NE, Taverna D, Harwerth IM, Ciardiello F, Salomon DS, Yamamoto T, Groner B 1990 Epidermal growth factor receptor, but not c-erbB-2, activation prevents lactogenic hormone induction of the β-casein gene in mouse mammary epithelial cells. Mol Cell Biol 10:4027-4034
36. Lincoln DT, Water MJ, Breipohl W, Sinowatz F, Lobie PE 1990 Growth hormone receptors expression in the proliferating rat mammary gland. Acta Histochem Suppl 40:47-49
37. Kaulsay KK, Zhu T, Bennett W, Lee KO, Lobie PE 2001 The effects of autocrine human growth hormone (hGH) on human mammary carcinoma cell behavior are mediated via the hGH receptor. Endocrinology 142:767-777
38. Zhang X, Zhu T, Chen Y, Mertani HC, Lee KO, Lobie PE 2003 Human growth hormone-regulated HOXA1 is a human mammary epithelial oncogene. J Biol Chem 278:7580-7590
39. Petersen OW, Ronnov-Jessen L, Howlett AR, Bissell MJ 1992 Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc Natl Acad Sci USA 89:9064-9068
40. Debnath J, Mills KR, Collins NL, Reginato MJ, Muthuswamy SK, Brugge JS 2002 The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 111:29-40
41. Runswick SK, O'Hare MJ, Jones L, Streuli CH, Garrod DR 2001 Desmosomal adhesion regulates epithelial morphogenesis and cell positioning. Nat Cell Biol 2001 3:823-830
42. Aggeler J, Ward J, Blackie LM, Barcellos-Hoff MH, Streuli CH, Bissell MJ 1991 Cytodifferentiation of mouse mammary epithelial cells cultured on a reconstituted basement membrane reveals striking similarities to development in vivo. J Cell Sci 99:407-417
43. Fialka I, Schwarz H, Reichmann E, Oft M, Busslinger M, Beug H 1996 The estrogen-dependent c-JunER protein causes a reversible loss of mammary epithelial cell polarity involving a destabilization of adherens junctions. J Cell Biol 132:1115-1132
44. Brisken C 2002 Hormonal control of alveolar development and its implications for breast carcinogenesis. J Mammary Gland Biol Neoplasia 7:39-48
45. Ilkbahar YN, Thordarson G, Camarillo IG, Talamantes F 1999 Differential expression of the growth hormone receptor and growth hormone-binding protein in epithelia and stroma of the mouse mammary gland at various physiological stages. J Endocrinol 161:77-87
46. Taverna D, Groner B, Hynes NE 1991 Epidermal growth factor receptor, platelet-derived growth factor receptor, and c-erbB-2 receptor activation all promote growth but have distinctive effects upon mouse mammary epithelial cell differentiation. Cell Growth Differ 2:145-154
47. Cerrito MG, Galbaugh T, Wang W, Chopp T, Salomon D, Cutler ML 2004 Dominant negative Ras enhances lactogenic hormone-induced differentiation by blocking activation of the Raf-Mek-Erk signal transduction pathway. J Cell Physiol 201:244-258
48. Zhu Z, Mukhina S, Zhu T, Mertani HC, Lee KO, Lobie PE 2005 p44/42 MAP kinase-dependent regulation of catalase by autocrine human growth hormone protects human mammary carcinoma cells from oxidative stress-induced apoptosis. Oncogene 24:3774-3785
49. Graichen R, Liu D, Sun Y, Lee KO, Lobie PE 2002 Autocrine human growth hormone inhibits placental transforming growth factor-β gene transcription to prevent apoptosis and allow cell cycle progression of human mammary carcinoma cells. J Biol Chem 277:26662-266672
50. Trichopoulos D, Hsieh CC, MacMahon B, Lin TM, Lowe CR, Mirra AP, Ravnihar B, Salber EJ, Valaoras VG, Yuasa S 1983 Age at any birth and breast cancer risk. Int J Cancer 31:701-704
51. Kelsey JL, Gammon MD 1991 The epidemiology of breast cancer. CA Cancer J Clin 41:146-165
52. Medina D, Smith GH 1999 Chemical carcinogen-induced tumorigenesis in parous, involuted mouse mammary glands. J Natl Cancer Inst 91:967-969
53. Russo J, Russo IH 1980 Susceptibility of the mammary gland to carcinogenesis. II. Pregnancy interruption as a risk factor in tumor incidence. Am J Pathol 100:497-512
54. Thordarson G, Jin E, Guzman RC, Swanson SM, Nandi S, Talamantes F 1995 Refractoriness to mammary tumorigenesis in parous rats: is it caused by persistent changes in the hormonal environment or permanent biochemical alterations in the mammary epithelia? Carcinogenesis 16:2847-2853
55. Thordarson G, Van Horn K, Guzman RC, Nandi S, Talamantes F 2001 Parous rats regain high susceptibility to chemically induced mammary cancer after treatment with various mammotropic hormones. Carcinogenesis 22:1027-1033
56. Swanson SM, Unterman TG 2002 The growth hormone-deficient Spontaneous Dwarf rat is resistant to chemically induced mammary carcinogenesis. Carcinogenesis 23:977-982
57. Thordarson G, Semaan S, Low C, Ochoa D, Leong H, Rajkumar L, Guzman RC, Nandi S, Talamantes F 2004 Mammary tumorigenesis in growth hormone deficient spontaneous dwarf rats; effects of hormonal treatments. Breast Cancer Res Treat 87:277-290
58. Pollak M, Blouin MJ, Zhang JC, Kopchick JJ 2001 Reduced mammary gland carcinogenesis in transgenic mice expressing a growth hormone antagonist. Br J Cancer 85:428-430
59. Huttner A, Adams EF, Buchfelder M, Fahlbusch R 1994 Growth hormone gene structure in human pituitary somatotrophinomas: promoter region sequence and methylation studies. J Mol Endocrinol 12:167-172
60. Tornell J, Rymo L, Isaksson OG 1991 Induction of mammary adenocarcinomas in metallothionein promoter-human growth hormone transgenic mice. Int J Cancer 49:114-117
61. Goffin V, Shiverick KT, Kelly PA, Martial JA 1996 Sequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen, and related proteins in mammals. Endocr Rev 17:385-410
62. Wennbo H, Gebre-Medhin M, Gritli-Linde A, Ohlsson C, Isaksson OG, Tornell J 1997 Activation of the prolactin receptor but not the growth hormone receptor is important for induction of mammary tumors in transgenic mice. J Clin Invest 100:2744-2751