Delivery of hepatotrophic factors fails to enhance longer-term survival of subcutaneously transplanted hepatocytes

Tissue Engineering

Volumn 12, Issue 2, 2006, Pages 235-244

  Smith, Molly K ^a   Riddle, Kathryn W ^a   Mooney, David J ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH KINETICS; HEALTH CARE; POROUS MATERIALS; TISSUE CULTURE;

EPIDERMAL GROWTH FACTOR (EGF); HEPATOCYTE GROWTH FACTOR (HGF); TISSUE ENGINEERING; VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF);

TRANSPLANTATION (SURGICAL);

EPIDERMAL GROWTH FACTOR; SCATTER FACTOR; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; EMBRYO; HEPATOCYTE TRANSPLANTATION; HETEROTOPIC TRANSPLANTATION; MALE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SCID MOUSE; SURVIVAL TIME; TISSUE ENGINEERING; VASCULARIZATION;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL SURVIVAL; DELAYED-ACTION PREPARATIONS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; EPIDERMAL GROWTH FACTOR; HEPATOCYTE GROWTH FACTOR; HEPATOCYTES; HUMANS; MALE; MICE; MICE, SCID; MICROSPHERES; NEOVASCULARIZATION, PHYSIOLOGIC; NIH 3T3 CELLS; RATS; RATS, INBRED LEW; RECOMBINANT PROTEINS; TIME FACTORS; TISSUE ENGINEERING; TRANSPLANTATION, HETEROLOGOUS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

ANIMALIA;

EID: 33645511862     PISSN: 10763279     EISSN: None     Source Type: Journal    
DOI: 10.1089/ten.2006.12.235     Document Type: Article

References (30)

1. Davis, M.W., and Vacanti, J.P. Toward development of an implantable tissue engineered liver. Biomaterials 17, 365, 1996.
2. Mooney, D.J., Park, S., Kaufmann, P.M., Sano, K., McNamara, K., Vacanti, J.P., and Langer, R. Biodegradable sponges for hepatocyte transplantation. J. Biomed. Mat. Res. 29, 959, 1995.
3. Smith, M.K., Peters, M.C., Richardson, T.P., Garbern, J.C., and Mooney, D.J. Locally enhanced angiogenesis promotes transplanted cell survival. Tissue Eng. 10, 63, 2004.
4. Mooney, D.J., Kaufmann, P.M., Sano, K., Schwendeman, S.P., Majahod, K., Schloo, B., Vacanti, J.P., and Langer, R. Localized delivery of epidermal growth factor improves the survival of transplanted hepatocytes. Biotech. Bioeng. 50, 422, 1995.
5. Kneser, U., Kaufmann, P.M., Fiegel, H.C., Pollok, J.M., Kluth, D., Herbst, H., and Rogiers, X. Long-term differentiated function of heterotopically transplanted hepatocytes on three-dimensional polymer matrices. J. Biomed. Mat. Res. 47, 494, 1999.
6. Kaufmann, P.M., Sano, K., Breuer, C.K., Organ, G.M., Schloo, B.L., Kluth, D., and Vacanti, J.P. Evaluation of methods of hepatotrophic stimulation in rat heterotopic hepatocyte transplantation using polymers. J. Pediatr. Surg. 34, 1118, 1999.
7. Stein, J.E., Gilbert, J.C., Hansen, L.K., Schloo, B., Ingber, D., and Vacanti, J.P. Hepatocyte transplantation into prevascularized porous matrices. Abstract presented at the American Pediatric Surgical Association Meeting, Lake Buena Vista, FL, 1996.
8. Stolz, D.B., Mars, W.M., Petersen, B.E., Kim, T.H., and Michalopoulos, G.K. Growth factor signal transduction-immediately after two-thirds partial hepatectomy in the rat. Cancer Res. 59, 3954, 1999.
9. Kinoshita, T., Hirao, S., Matsumoto, K., and Nakamura, T. Possible endocrine control by hepatocyte growth factor of liver regeneration after partial hepatectomy. Biochem. Biophys. Res. Com. 177, 330, 1991.
10. Zarnegar, R., DeFrances, M.C., Kost, D.P., Lindroos, P., and Michalopoulos, G.K. Expression of hepatocyte growth factor mRNA in regenerating rat liver after partial hepatectomy. Biochem. Biophys. Res. Com. 177, 559, 1991.
11. Noguchi, S., Ohba, Y., and Oka, T. Influence of epidermal growth factor on liver regeneration after partial hepatectomy in mice. J. Endocrinol. 128, 425, 1991.
12. Mullhaupt, B., Feren, A., Fodor, E., and Jones, A. Liver expression of epidermal growth factor RNA. Rapid increases in immediate-early phase of liver regeneration. J. Biol. Chem. 269, 19667, 1994.
13. Michalopoulos, G.K., Bowen, W., Nussler, A.K., Becich, M.J., and Howard, T.A. Comparative analysis of mitogenic and morphogenic effects of HGF and EGF on rat and human hepatocytes maintained in collagen gels. J. Cell Phys. 156, 443, 1993.
14. Musallam, L., Ethier, C., Haddad, P.S., and Bilodeau, M. Role of EGF receptor tyrosine kinase activity in antiapoptotic effect of EGF on mouse hepatocytes. Am. J. Physiol. 280, G1360, 2001.
15. Kim, T.H., Lee, H.M., Utsonomiya, H., Ma, P., Langer, R., Schmidt, E.V., and Vacanti, J.P. Enhanced survival of transgenic hepatocytes expressing hepatocyte growth factor in hepatocyte tissue engineering. Transpl. Proc. 29, 858, 1997.
16. Ajioka, I., Nishio, R., Ikekita, M., Akaike, T., Sasaki, M., Enami, J., and Watanabe, Y. Establishment of heterotopic liver tissue mass with direct link to the host liver following implantation of hepatocytes transfected with vascular endothelial growth factor gene in mice. Tissue Eng. 7, 335, 2001.
17. Mooney, D.J., Baldwin, D.F., Suh, N.P., Vacanti, J.P., and Langer, R. Novel approach to fabricate porous sponges of poly(D,L-lactic-co-glycolic acid) without the use of organic solvents. Biomaterials 17, 1417, 1996.
18. Richardson, T.P., and Mooney, D.J. Gas foam processing for tissue engineering applications. In: Atala, A., and Lanza, R., eds., Methods of Tissue Engineering. San Diego: Academic Press, 2001, pp. 653-662.
19. Cohen, S., Yoshioka, T., Lucarelli, M., Hwang, L.H., and Langer, R. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres. Pharmacol. Res. 8, 713, 1991.
20. Aiken, J., Cima, L., Schloo, B., Mooney, D., Johnson, L., Langer, R., and Vacanti, J.P. Studies in rat liver perfusion for optimal harvest of hepatocytes. J. Pediatr. Surg. 25, 140, 1990.
21. Jaffe, V., Darby, H., Bishop, A., and Hodgson, H.J. The growth of liver cells in the pancreas after intra-splenic implantation: the effects of portal perfusion. Int. J. Exp. Pathol. 72, 289, 1991.
22. Lee, H., Cusick, R.A., Browne, F., Kim, T.H., Ma, P.X., Utsunomiya, H., Langer, R., and Vacanti, J.P. Local delivery of basic fibroblast growth factor increases both angiogenesis and engraftment of hepatocytes in tissue-engineered polymer devices. Transplantation 73, 1589, 2002.
23. Richardson, T.P., Peters, M.C., Ennett, A.B., and Mooney, D.J. Polymeric system for dual growth factor delivery. Nat. Biotech. 19, 1029, 2001.
24. Kuwano, M., Ushiro, S., Ryuto, M., Samoto, K., Izumi, H., Ito, K., Abe, T., Nakamura, T., Ono, M., and Kohno, K. Regulation of angiogenesis by growth factors. In: Nakamura, T., and Matsumoto, K., eds., Growth Factors: Cell Growth, Morphogenesis and Transformation. Tokyo: Japan Scientific Press, 1993, pp.113-125.
25. Xin, X., Yang, S., Ingle, G., Zlot, C., Rangell, L., Kowalski, J., Schwall, R., Ferrara N., and Gerritsen, M.E. Hepatocyte growth factor enhances vascular endothelial growth factor-induced angiogenesis in vitro and in vivo. Am. J. Pathol. 158, 1111, 2001.
26. Morimoto, A., Okamura, K., Hamanaka, R., Sato, Y., Shima, N., Higashioo, K., and Kuwano, M. Hepatocyte growth factor modulates migration and proliferation of human microvascular endothelial cells in culture. Biochem. Biophys. Res. Com. 179, 1042, 1991.
27. Kumar, R., Yoneda, J., Bucara, C.D., and Fider, I.J. Regulation of distinct steps of angiogenesis by different angiogenic molecules. Int. J. Oncol. 12, 749, 1998.
28. Van Belle, E., Witzenbichler, B., Chen, D., Silver, M., Chang, L., Schwall, R., and Isner, J.M. Potentiated angiogenic effect of scatter factor/hepatocyte growth factor: the case for paracrine amplification of angiogenesis. Circulation 97, 38, 1998.
29. Wojta, J., Kaun, C., Breuss, J.M., Koshelnick, Y., Beckmann, R., Hattey, E., Mildner, M., Weninger, W., Nakamura, T., Tschachler, E., and Binder, B.R. Hepatocyte growth factor increases expression of vascular endothelial growth factor and plasminogen activator inhibitor-1 in human keratinocytes and the vascular endothelial growth factor receptor flk-1 in human endothelial cells. Lab. Invest. 79, 427, 1999.
30. Gille, J., Khalik, M., Konig, V., and Kaufmann, R. Hepatocyte growth factor/scatter factor induces vascular permeability factor expression by cultured keratinocytes. J. Invest. Dermatol. 111, 1160, 1998.