Modulation of gamma-aminobutyric acidA receptor function by thiopental in the rat spinal dorsal horn neurons

Anesthesia and Analgesia

Volumn 102, Issue 4, 2006, Pages 1114-1120

  Yang, Chuan Xiu ^a,b,c   Xu, Han ^a,b   Zhou, Ke Qing ^a   Wang, Meng Ya ^c   Xu, Tian Le ^a,b  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^c WANNAN MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; ANESTHETIC AGENT; BICUCULLINE; GLYCINE RECEPTOR ANTAGONIST; STRYCHNINE; THIOPENTAL;

ANALGESIA; ANIMAL CELL; ANTINOCICEPTION; ARTICLE; CHLORIDE CONDUCTANCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; GENERAL ANESTHESIA; NERVE CELL; NEUROTRANSMISSION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SPINAL CORD DORSAL HORN;

EID: 33645501238     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ane.0000198657.76705.38     Document Type: Article

References (25)

1. Rampil IJ. Anesthetic potency is not altered after hypothermic spinal cord transection in rats. Anesthesiology 1994;80:606-10.
2. Antognini JF. The relationship among brain, spinal cord and anesthetic requirements. Med Hypotheses 1997;48:83-7.
3. Kendig JJ. In vitro networks: subcortical mechanisms of anaesthetic action. Br J Anaesth 2002;89:91-101.
4. Franks NP, Lieb WR. Molecular and cellular mechanisms of general anaesthesia. Nature 1994;367:607-14.
5. Cordato DJ, Chebib M, Mather LE, et al. Stereoselective interaction of thiopentone enantiomers with the GABA(A) receptor. Br J Pharmacol 1999;128:77-82.
6. Dickinson R, de Sousa SL, Lieb WR, Franks NP. Selective synaptic actions of thiopental and its enantiomers. Anesthesiology 2002;96:884-92.
7. Gustafsson LL, Ebling WF, Osaki E, Stanski DR. Quantitation of depth of thiopental anesthesia in the rat. Anesthesiology 1996;84:415-27.
8. Lu H, Xu TL. The general anesthetic pentobarbital slows desensitization and deactivation of the glycine receptor in the rat spinal dorsal horn neurons. J Biol Chem 2002;277:41369-78.
9. Wu LJ, Lu Y, Xu TL. A novel mechanical dissociation technique for studying acutely isolated maturing Drosophila central neurons. J Neurosci Methods 2001;108:199-206.
10. Li Y, Wu LJ, Legendre P, Xu TL. Asymmetric cross-inhibition between GABAA and glycine receptors in rat spinal dorsal horn neurons. J Biol Chem 2003;278:38637-45.
11. Nelson LE, Guo TZ, Lu J, et al. The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway. Nat Neurosci 2002;5:979-84.
12. Antognini JF, Carstens E, Atherley R. Does the immobilizing effect of thiopental in brain exceed that of halothane? Anesthesiology 2002;96:980-6.
13. Devor M, Zalkind V. Reversible analgesia, atonia, and loss of consciousness on bilateral intracerebral microinjection of pentobarbital. Pain 2001;94:101-12.
14. Sudo M, Sudo S, Chen XG, et al. Thiopental directly depresses lumbar dorsal horn neuronal responses to noxious mechanical stimulation in goats. Acta Anaesthesiol Scand 2001;45:823-9.
15. Jewett BA, Gibbs LM, Tarasiuk A, Kendig JJ. Propofol and barbiturate depression of spinal nociceptive neurotransmission. Anesthesiology 1992;77:1148-54.
16. Dong XP, Xu TL. The actions of propofol on gamma-aminobutyric acid-A and glycine receptors in acutely dissociated spinal dorsal horn neurons of the rat. Anesth Analg 2002;95:907-14.
17. Zhang ZX, Lu H, Dong XP, et al. Kinetics of etomidate actions on GABA(A) receptors in the rat spinal dorsal horn neurons. Brain Res 2002;953:93-100.
18. Miledi R, Parker I. Chloride current induced by injection of calcium into Xenopus oocytes. J Physiol (Lond) 1984;357:173-83.
19. Lim MS, Lindquist CE, Birnir B. Effects of pentobarbital on GABA-activated currents in acutely-isolated rat dentate gyrus granule neurons. Neurosci Lett 2003;353:139-42.
20. Kitamura A, Marszalec W, Yeh JZ, Narahashi T. Effects of halothane and propofol on excitatory and inhibitory synaptic transmission in rat cortical neurons. J Pharmacol Exp Ther 2003;304:162-71.
21. Zhan RZ, Fujiwara N, Yamakura T, et al. Differential inhibitory effects of thiopental, thiamylal and phenobarbital on both voltage-gated calcium channels and NMDA receptors in rat hippocampal slices. Br J Anaesth 1998;81:932-9.
22. Todorovic SM, Lingle CJ. Pharmacological properties of T-type Ca2+ current in adult rat sensory neurons: effects of anticonvulsant and anesthetic agents. J Neurophysiol 1998;79:240-52.
23. Takeda D, Nakatsuka T, Papke R, Gu JG. Modulation of inhibitory synaptic activity by a non-alpha4beta2, non-alpha7 subtype of nicotinic receptors in the substantia gelatinosa of adult rat spinal cord. Pain 2003;101:13-23.
24. Coates KM, Mather LE, Johnson R, Flood P. Thiopental is a competitive inhibitor at the human alpha7 nicotinic acetylcholine receptor. Anesth Analg 2001;92:930-3.
25. Flood P, Krasowski MD. Intravenous anesthetics differentially modulate ligand-gated ion channels. Anesthesiology 2000;92:1418-25.