Adaptive immunity-dependent intestinal hypermotility contributes to host defense against Giardia spp.

Infection and Immunity

Volumn 74, Issue 4, 2006, Pages 2473-2476

  Andersen, Yolanda S ^a   Gillin, Frances D ^b   Eckmann, Lars ^a,c  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARMINIC ACID; LOPERAMIDE; PHOSPHATE BUFFERED SALINE;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIARRHEA; DRUG MECHANISM; GIARDIA; GIARDIA LAMBLIA; GIARDIA MURIS; GIARDIASIS; HOST PARASITE INTERACTION; HOST RESISTANCE; INTESTINAL DYSMOTILITY; INTESTINE MOTILITY; INTESTINE TRANSIT TIME; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SCID MOUSE; SMALL INTESTINE; TROPHOZOITE;

ANIMALS; ANTIDIARRHEALS; DISEASE MODELS, ANIMAL; GASTROINTESTINAL MOTILITY; GIARDIASIS; IMMUNITY, ACTIVE; LOPERAMIDE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; NITRIC OXIDE SYNTHASE TYPE I;

EID: 33645499506     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.74.4.2473-2476.2006     Document Type: Article

References (23)

1. Al-Abri, S. S., N. J. Beeching, and F. J. Nye. 2005. Traveller's diarrhoea. Lancet Infect. Dis. 5:349-360.
2. Awouters, F., A. Megens, M. Verlinden, J. Schuurkes, C. Niemegeers, and P. A. Janssen. 1993. Loperamide. Survey of studies on mechanism of its antidiarrheal activity. Dig. Dis. Sci. 38:977-995.
3. Byrd, L. G., J. T. Conrad, and T. E. Nash. 1994. Giardia lamblia infections in adult mice. Infect. Immun. 62:3583-3585.
4. Castro, G. A., F. Badial-Aceves, J. W. Smith, S. J. Dudrick, and N. W. Weisbrodt. 1976. Altered small bowel propulsion associated with parasitism. Gastroenterology 71:620-625.
5. Deselliers, L. P., D. T. Tan, R. B. Scott, and M. E. Olson. 1997. Effects of Giardia lamblia infection on gastrointestinal transit and contractility in Mongolian gerbils. Dig. Dis. Sci. 42:2411-2419.
6. Eckmann, L. 2003. Mucosal defences against Giardia. Parasite Immunol. 25:259-270.
7. Farmer, S. G. 1981. Propulsive activity of the rat small intestine during infection with the nematode Nippostrongylus brasiliensis. Parasite Immunol. 3:227-234.
8. Faubert, G. 2000. Immune response to Giardia duodenalis. Clin. Microbiol. Rev. 13:35-54.
9. Langford, T. D., M. P. Housley, M. Boes, J. Chen, M. F. Kagnoff, F. D. Gillin, and L. Eckmann. 2002. Central importance of immunoglobulin A in host defense against Giardia spp. Infect. Immun. 70:11-18.
10. Li, E., P. Zhou, and S. M. Singer. 2006. Neuronal nitric oxide synthase is necessary for elimination of Giardia lamblia infections in mice. J. Immunol. 176:516-521.
11. Nash, T. E., D. A. Herrington, G. A. Losonsky, and M. M. Levine. 1987. Experimental human infections with Giardia lamblia. J. Infect. Dis. 156:974-984.
12. Oberhuber, G., N. Kastner, and M. Stolte. 1997. Giardiasis: a histologic analysis of 567 cases. Scand. J. Gastroenterol. 32:48-51.
13. Puig, M. M., and O. Pol. 1998. Peripheral effects of opioids in a model of chronic intestinal inflammation in mice. J. Pharmacol. Exp. Ther. 287:1068-1075.
14. Read, N. W., C. A. Miles, D. Fisher, A. M. Holgate, N. D. Kime, M. A. Mitchell, A. M. Reeve, T. B. Roche, and M. Walker. 1980. Transit of a meal through the stomach, small intestine, and colon in normal subjects and its role in the pathogenesis of diarrhea. Gastroenterology 79:1276-1282.
15. Reeder, M. M. 1997. Radiological diagnosis of giardiasis. Semin. Roentgenol. 32:291-300.
16. Scott, K. G.-E., M. R. Logan, G. M. Klammer, D. A. Teoh, and A. G. Buret. 2000. Jejunal brush border microvillous alterations in Giardia muris-infected mice: role of T lymphocytes and interleukin-6. Infect. Immun. 68:3412-3418.
17. + T lymphocytes in jejunal mucosal injury during murine giardiasis. Infect. Immun. 72:3536-3542.
18. Singer, S. M., and T. E. Nash. 2000. T-cell-dependent control of acute Giardia lamblia infections in mice. Infect. Immun. 68:170-175.
19. Sukhdeo, M. V., and N. A. Croll. 1981. Gut propulsion in mice infected with Trichinella spiralis. J. Parasitol. 67:906-910.
20. Takahashi, T. 2003. Pathophysiological significance of neuronal nitric oxide synthase in the gastrointestinal tract. J. Gastroenterol. 38:421-430.
21. Tan-No, K., F. Niijima, O. Nakagawasai, T. Sato, S. Satoh, and T. Tadano. 2003. Development of tolerance to the inhibitory effect of loperamide on gastrointestinal transit in mice. Eur. J. Pharm. Sci. 20:357-363.
22. Thompson, R. C. 2000. Giardiasis as a re-emerging infectious disease and its zoonotic potential. Int. J. Parasitol. 30:1259-1267.
23. Vallance, B. A., and S. M. Collins. 1998. The effect of nematode infection upon intestinal smooth muscle function. Parasite Immunol. 20:249-253.