The regulation of human adrenomedullin (AM) and tumor necrosis factor α (TNF-α) receptors on human epithelial carcinoma (HeLa) cells. The role of AM secretion in tumor cell sensitivity

Neoplasma

Volumn 53, Issue 2, 2006, Pages 144-149

  Drimal, J ^a   Drimal, D ^b   Drimal Jr , J ^c  

^a INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

^b SLOVAK UNIVERSITY OF TECHNOLOGY   (Slovakia)

^c Slovak Gas Industry ^*  (Slovakia)

Author keywords

Adrenomedullin; AM production; Cells in culture; Epithelial carcinoma cells; HeLa; Proliferation; Receptors; TNF

Indexed keywords

1 (2,6 DIISOPROPYLPHENYL) 3 (4,4' NITROPHENYLTHIO)PHENYLUREA; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ADRENOMEDULLIN; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); DACTINOMYCIN; ENDOTHELIN 1; HISTAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; TUMOR NECROSIS FACTOR ALPHA RECEPTOR; UNCLASSIFIED DRUG; VULM 1457;

APOPTOSIS; ARTICLE; CELL MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; HELA CELL; HUMAN; HUMAN CELL; HYPOXIA; LIGAND BINDING; PROTEIN BINDING; PROTEIN SECRETION; TUMOR CELL; UPREGULATION;

EID: 33645472582     PISSN: 00282685     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. HOHMANN HP, REMY R, BROCKHAUS M, VANLOON AP. Two different cell types have different major receptors for human tumor necrosis factor (TNFα). J Biol Chem 1989; 264: 14927-14934.
2. TARTAGLIA LA, PENNICA D, GOEDDEL DV. Ligand passing: the 78-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor. J Biol Chem and Mol Biol 1993; 268: 18542-18548.
3. WAJANT H, SEURICH P. Tumor necrosis receptor-associated factor (TRAF)2 and its role in TNF signalling. Int J Biochem Cell Biol 2001; 33(1): 19-32.
4. LOCKSLEY RM, KILLEEN N, LENARDO MJ. The TNF and TNF receptor superfamilies:integrating mammalian biology. Cell 2001; 104(4): 487-501.
5. MILLER JM, MARTINEZ A, UNSWORTH EJ, THIELE CJ, MOODY TW et al. Adrenomedullin expression in human tumor cell lines. J Biol Chem 1996; 271: 23345-23356.
6. BROCKHAUS M, SCHOENFELD HJ, SCHLAEGER EJ, HUNZINKER W, LESSLAUER W et al. Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies. Proc Natl Acad Sci USA 1990; 87: 3127-3131.
7. WANG J, RAFIA S, LAMKI A, ZHANG H, KIRKILES-SMITH N et al. Histamine antagonizes tumor necrosis factor signaling by stimulating TNF receptor shedding from the cell surface and Golgi storage pool. J Biol Chem 2003; 278: 21751-21760.
8. BRADFORD MM. A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-253.
9. 2 levels as a mechanism by which the p70TNF receptors enhance apoptosis. FEBS Lett 1996; 379: 77-81.
10. B receptor down-regulation in human tumor cells. Eur J Pharmacol 2000; 396: 19-22.
11. MCFARLANE SM, PASHINI G, CONNEL MC, LITTLE-JOHN AF, TUCKERS SJ et al. Differential activation of nuclear factor kappa B by TNF receptor subtypes. TNFR-1 predominates whereas TNFR-2 activates transcription poorly. Febs Lett 2002; 27: 119-126.
12. KUSUOKI J, HAUSOTY DK, ARGANE K, FALLON JT, BADIMON JJ, FISHER EA. Acyl-CoA: cholesterol-acyl-transferase inhibition reduces atherosclerosis in apo-lipoprotein-E deficient mice. Circulation 2001; 103: 2604-2611.
13. FABEROVA V, KAKALIK I, JURANOVA D, SCHMIDTOVA L, ZIGOVA J et al. VULM1457- a novel hypocholesterelomic and antisclerotic agent. Bratisl Lek Listy 2002; 103: 312-315 (in Slovak).
14. OREMUS V, SMAHOVSKY V, FABEROVA V, KAKALIK I, SCHMIDTOVA L, ZEMANEK M. 1,3-disubstituted ureas as ACAT inhibitors and method preparing thereof. WO - 9932437, CA, USA, 131, 73411c.
15. PIERCE JW, SCHOENLEBER R, JESMOK G, BEST J, MOORE SA et al. Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show antiinflammatory effects in vivo. J Biol Chem 1997; 272: 21096-21103.
16. κB. BMC Molec Biol 2002; 3: 16.