Fusion of ETV6 with an intronic sequence of the BAZ2A gene in a paediatric pre-B acute lymphoblastic leukaemia with a cryptic chromosome 12 rearrangement

British Journal of Haematology

Volumn 133, Issue 3, 2006, Pages 270-275

  Panagopoulos, Ioannis ^a   Strömbeck, Bodil ^a   Isaksson, Margareth ^a   Heldrup, Jesper ^a   Olofsson, Tor ^a   Johansson, Bertil ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Acute leukaemia; BAZ2A; ETV6; Gene fusion

Indexed keywords

COMPLEMENTARY DNA; RNA; TRANSCRIPTION FACTOR ETS; TRANSCRIPTION FACTOR ETV6; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; AMINO ACID SEQUENCE; ARTICLE; BAZ2A GENE; CASE REPORT; CHILD; CHILDHOOD LEUKEMIA; CHROMOSOME 12P; CHROMOSOME REARRANGEMENT; FEMALE; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; HUMAN; HUMAN CELL; LEUKEMOGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; BASE SEQUENCE; CHILD, PRESCHOOL; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOMES, HUMAN, PAIR 12; FEMALE; GENE FUSION; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, B-CELL, ACUTE; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS C-ETS; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 33645457574     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2006.06020.x     Document Type: Article

References (16)

1. Belloni E. Trubia M. Mancini M. Derme V. Nanni M. Lahortiga I. Riccioni R. Confalonieri S. Lo-Coco F. Di Fiore P.P. Pelicci P.G. 2004 A new complex rearrangement involving the ETV6, LOC115548, and MN1 genes in a case of acute myeloid leukemia. Genes, Chromosomes and Cancer 41 272 277.
2. Bohlander S.K. 2005 ETV6: a versatile player in leukemogenesis. Seminars in Cancer Biology 15 162 174.
3. Cools J. Mentens N. Odero M.D. Peeters P. Wlodarska I. Delforge M. Hagemeijer A. Marynen P. 2002 Evidence for position effects as a variant ETV6-mediated leukemogenic mechanism in myeloid leukemias with t (4;12) (q11-q12;p13) or t (5;12) (q31;p13). Blood 99 1776 1784.
4. Gustafsson G. Schmiegelow K. Forestier E. Clausen N. Glomstein A. Jonmundsson G. Mellander L. Mäkipernaa A. Nygaard R. Saarinen-Pihkala U.M. 2000 Improving outcome through two decades in childhood ALL in the Nordic countries: the impact of high-dose methotrexate in the reduction of CNS irradiation. Leukemia 14 2267 2275
5. Johansson B. Mertens F. Mitelman F. 2004 Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute lymphoblastic leukemia. Annals of Medicine 36 492 503.
6. Jones M.H. Hamana N. Nezu J. Shimane M. 2000 A novel family of bromodomain genes. Genomics 63 40 45.
7. Mitelman F. Johansson B. Mertens F. 2005 Mitelman database of chromosome aberrations in cancer. [WWW document]. URL http://cgap.nci.nih.gov/Chromosomes/ Mitelman [accessed on 2 December 2005]
8. Mrózek K. Heerema N.A. Bloomfield C.D. 2004 Cytogenetics in acute leukemia. Blood Reviews 18 115 136.
9. Odero M.D. Vizmanos J.L. Roman J.P. Lahortiga I. Panizo C. Calasanz M.J. Zeleznik-Le N.J. Rowley J.D. Novo F.J. 2002 A novel gene, MDS2, is fused to ETV6/TEL in a t (1;12) (p36·1;p13) in a patient with myelodysplastic syndrome. Genes, Chromosomes and Cancer 35 11 19.
10. Panagopoulos I. Mertens F. Domanski H.A. Isaksson M. Brosjö O. Gustafson P. Mandahl N. 2001 No EWS/FLI1 fusion transcripts in giant-cell tumors of bone. International Journal of Cancer 93 769 772.
11. Penas E.M. Cools J. Algenstaedt P. Hinz K. Seeger D. Schafhausen P. Schilling G. Marynen P. Hossfeld D.K. Dierlamm J. 2003 A novel cryptic translocation t (12;17) (p13;p12-p13) in a secondary acute myeloid leukemia results in a fusion of the ETV6 gene and the antisense strand of the PER1 gene. Genes, Chromosomes and Cancer 37 79 83.
12. Poot R.A. Dellaire G. Hulsmann B.B. Grimaldi M.A. Corona D.F. Becker P.B. Bickmore W.A. Varga-Weisz P.D. 2000 HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins. EMBO Journal 19 3377 3387.
13. Rowley J.D. 2001 Chromosome translocations: dangerous liaisons revisited. Nature Reviews Cancer 1 245 250.
14. Sato Y. Bohlander S.K. Kobayashi H. Reshmi S. Suto Y. Davis E.M. Espinosa R. Hoopes R. Montgomery K.T. Kucherlapati R.S. Le Beau M.M. Rowley J.D. 1997 Heterogeneity in the breakpoints in balanced rearrangements involving band 12p13 in hematologic malignancies identified by fluorescence in situ hybridization: TEL (ETV6) is involved in only one half. Blood 90 4886 4893.
15. Strohner R. Nemeth A. Jansa P. Hofmann-Rohrer U. Santoro R. Langst G. Grummt I. 2001 NoRC - a novel member of mammalian ISWI-containing chromatin remodeling machines. EMBO Journal 20 4892 4900.
16. Yagasaki F. Jinnai I. Yoshida S. Yokoyama Y. Matsuda A. Kusumoto S. Kobayashi H. Terasaki H. Ohyashiki K. Asou N. Murohashi I. Bessho M. Hirashima K. 1999 Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t (5;12) (q31;p13). Genes, Chromosomes and Cancer 26 192 202.