MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen

Biochemistry

Volumn 45, Issue 12, 2006, Pages 3863-3874

  Turk, Benjamin E ^a   Lee, Daniel H ^b   Yamakoshi, Yasuo ^c   Klingenhoff, Andreas ^d   Reichenberger, Ernst ^e   Wright, J Timothy ^f   Simmer, James P ^c   Komisarof, Justin A ^g   Cantley, Lewis C ^h   Bartlett, John D ^b,i  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FORSYTH INSTITUTE   (United States)

^c UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

^d Genomatix GmbH   (Germany)

^e UNIVERSITY OF CONNECTICUT SCHOOL OF DENTAL MEDICINE   (United States)

^f UNIVERSITY OF NORTH CAROLINA   (United States)

^g Center for Excellence in Education   (United States)

^h BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

ⁱ HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; CATALYSIS; COLLAGEN; HYDROLYSIS; TISSUE; TOOTH ENAMEL;

INTESTINE; METALLOPROTEINASE; TISSUE EXPRESSION; TOOTH-SPECIFIC REGULATORY ELEMENTS;

ENZYMES;

AMELOBLASTIN; AMELOGENIN; COLLAGEN TYPE 5; ENAMELIN; GENE PRODUCT; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 20; PEPTIDE LIBRARY; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CATALYSIS; COMPUTER MODEL; ENAMEL; ENZYME SPECIFICITY; GENE; GENE CONTROL; GENE SEQUENCE; MMP20 GENE; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; TOOTH DEVELOPMENT; TOOTH PULP;

ANIMALS; ANIMALS, NEWBORN; BASE SEQUENCE; BLOTTING, SOUTHERN; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLONING, MOLECULAR; COLLAGEN TYPE V; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HYDROLYSIS; MATRIX METALLOPROTEINASE 20; MATRIX METALLOPROTEINASES; MICE; PROMOTER REGIONS (GENETICS); RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOOTH;

ANIMALIA; MURINAE;

EID: 33645453182     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi052252o     Document Type: Article

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