Mast cell activation and leukotriene secretion in wheezing infants. Relation to respiratory syncytial virus and outcome

Pediatric Allergy and Immunology

Volumn 17, Issue 1, 2006, Pages 37-42

  Øymar, Knut ^a,b   Halvorsen, Thomas ^b   Aksnes, Lage ^b  

^a STAVANGER UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

Author keywords

Eosinophils; Infants; Leukotrienes; LTE4; Mast cells; PGF2; Prostaglandins; Respiratory syncytial virus; Wheezing

Indexed keywords

11 EPIPROSTAGLANDIN F2 ALPHA; BIOLOGICAL MARKER; LEUKOTRIENE E4;

ARTICLE; CELL ACTIVATION; CELL FUNCTION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE RELEASE; DISEASE ASSOCIATION; EOSINOPHILIA; FEMALE; FOLLOW UP; HUMAN; IMMUNOPATHOLOGY; IMMUNOSTIMULATION; INFANT; MAJOR CLINICAL STUDY; MALE; MAST CELL; OUTCOMES RESEARCH; PRIORITY JOURNAL; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RISK FACTOR; URINE LEVEL; VIRUS INFECTION; WHEEZING;

EOSINOPHIL-DERIVED NEUROTOXIN; EOSINOPHILS; FEMALE; HUMANS; INFANT; LEUKOCYTE COUNT; LEUKOTRIENE E4; LEUKOTRIENES; MALE; MAST CELLS; REGRESSION ANALYSIS; RESPIRATORY SOUNDS; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS;

EID: 33645316521     PISSN: 09056157     EISSN: 13993038     Source Type: Journal    
DOI: 10.1111/j.1399-3038.2005.00345.x     Document Type: Article

References (19)

1. B isgaard H. Persistent wheezing in very young preschool children reflects lower respiratory inflammation. Am J Respir Crit Care Med 2001 163 1290 1.
2. S tevenson EC T urner G H eaney LG et al. Bronchoalveolar lavage findings suggest two different forms of childhood asthma. Clin Exp Allergy 1997 27 1027 35.
3. M artinez FD S tern DA W right AL T aussig LM H alonen M. Differential immune responses to acute lower respiratory illness in early life and subsequent development of persistent wheezing and asthma. J Allergy Clin Immunol 1998 102 915 20.
4. Ø ymar K H avnen J H alvorsen T B jerknes R. Eosinophil counts and urinary eosinophil protein X in children hospitalized for wheezing during the first year of life: prediction of recurrent wheezing. Acta Paediatr 2001 90 843 9.
5. P ifferi M R agazzo V C aramella D B aldini G. Eosinophil cationic protein in infants with respiratory syncytial virus bronchiolitis: predictive value for subsequent development of persistent wheezing. Pediatr Pulmonol 2001 31 419 24.
6. P uxeddu I L evi -S chaffer F. Mast cells and eosinophils: the hallmark of asthma. Paediatr Respir Rev 2004 5 Suppl. A S31 4.
7. O'S ullivan S. On the role of PGD2 metabolites as markers of mast cell activation in asthma. Acta Physiol Scand Suppl 1999 644 1 74.
8. O'S ullivan S M ueller MJ D ahlen SE K umlin M. Analyses of prostaglandin D2 metabolites in urine: comparison between enzyme immunoassay and negative ion chemical ionisation gas chromatography-mass spectrometry. Prostaglandins Other Lipid Mediat 1999 57 149 65.
9. S ampson AP. The leukotrienes: mediators of chronic inflammation in asthma. Clin Exp Allergy 1996 26 995 1004.
10. van S chaik SM W elliver RC K impen JL. Novel pathways in the pathogenesis of respiratory syncytial virus disease. Pediatr Pulmonol 2000 30 131 8.
11. D imova -Y aneva D R ussell D M ain M B rooker RJ H elms PJ. Eosinophil activation and cysteinyl leukotriene production in infants with respiratory syncytial virus bronchiolitis. Clin Exp Allergy 2004 34 555 8.
12. W edde -B eer K H u C R odriguez MM P iedimonte G. Leukotrienes mediate neurogenic inflammation in lungs of young rats infected with respiratory syncytial virus. Am J Physiol Lung Cell Mol Physiol 2002 282 1143 50.
13. S everien C A rtlich A J onas S B echer G. Urinary excretion of leukotriene E4 and eosinophil protein X in children with atopic asthma. Eur Respir J 2000 16 588 92.
14. D ahl R B jermer L Nordic consensus report on asthma management. Nordic Asthma Consensus Group. Respir Med 2000 94 299 327.
15. B rightling CE B radding P P avord ID W ardlaw AJ. New insight into the role of the mast cell in asthma. Clin Exp Allergy 2003 33 550 6.
16. van S chaik SM T ristram DA N agpal IS H intz KM W elliver RC II. W elliver RC. Increased production of IFN-gamma and cysteinyl leukotrienes in virus-induced wheezing. J Allergy Clin Immunol 1999 103 630 6.
17. K rawiec ME W estcott JY C hu HW et al. Persistent wheezing in very young children is associated with lower respiratory inflammation. Am J Respir Crit Care Med 2001 163 1338 43.
18. B isgaard H Study Group on Montelukast and Respiratory Syncytial Virus. A randomized trial of montelukast in respiratory syncytial virus postbronchiolitis. Am J Respir Crit Care Med 2003 167 379 83.
19. B isgaard H. Leukotriene modifiers in pediatric asthma management. Pediatrics 2001 107 381 90.