NK026680, a novel compound suppressive of dendritic cell function, ameliorates mortality in acute lethal graft-versus-host reaction in mice

Bone Marrow Transplantation

Volumn 37, Issue 3, 2006, Pages 317-323

  Saiga, K ^a,b   Toyoda, E ^a   Tokunaka, K ^a   Masuda, A ^a   Matsumoto, S ^a   Mashiba, H ^a   Kuramochi, H ^a   Nemoto, K ^a   Abe, F ^a   Kawagishi, N ^b   Furukawa, H ^b   Ono, M ^b  

^a NIPPON KAYAKU CO LTD   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Dendritic cell; Graft versus host disease; GVHD; Immunosuppressant; NK026680; transplantation

Indexed keywords

1 (5 HYDROXY 1,5 DIMETHYLHEXYL) 3 [7 (4 METHOXYPHENYL) [1,2,4]TRIAZOLO[1,5 ALPHA]PYRIMIDIN 2 YL]UREA; B7 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 12P40; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NK 026680; UNCLASSIFIED DRUG;

ACUTE GRAFT VERSUS HOST DISEASE; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CYTOKINE RELEASE; DENDRITIC CELL; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG INDICATION; DRUG RESPONSE; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; DRUG USE; EARLY INTERVENTION; GENOTOXICITY; HUMAN; HUMAN CELL; IMMUNOPROPHYLAXIS; IMMUNOREGULATION; IMMUNOSUPPRESSIVE TREATMENT; LETHALITY; LYMPHOCYTE PROLIFERATION; MONOCYTE; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TOXICITY TESTING;

ADMINISTRATION, ORAL; ANIMALS; ANTIGENS, CD; ANTIGENS, CD86; DENDRITIC CELLS; GENE EXPRESSION REGULATION; GRAFT VS HOST DISEASE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; IMMUNOGLOBULINS; IMMUNOLOGIC FACTORS; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P35; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MOLECULAR STRUCTURE; PROTEIN SUBUNITS; PYRIMIDINES; TRIAZOLES;

EID: 33645278387     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/sj.bmt.1705231     Document Type: Article

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