Indexes of NO bioavailability in human blood

News in Physiological Sciences

Volumn 17, Issue 6, 2002, Pages 251-255

  Lauer, Thomas ^a   Kleinbongard, Petra ^a   Kelm, Malte ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CALMODULIN; CATALASE; CITRULLINE; FLAVINE ADENINE NUCLEOTIDE; FLAVINE MONONUCLEOTIDE; GUANYLATE CYCLASE; HEMOGLOBIN; N(G) HYDROXYARGININE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; OXYHEMOGLOBIN; S NITROSOTHIOL; SUPEROXIDE DISMUTASE; TETRAHYDROBIOPTERIN; XANTHINE OXIDASE;

ARTERIOSCLEROSIS; ARTICLE; ATHEROSCLEROSIS; BIOAVAILABILITY; BLOOD; CIRCULATION; DECOMPOSITION; ENZYME ACTIVITY; FOREARM BLOOD FLOW; HUMAN; LIPID PEROXIDATION; METABOLISM; NONHUMAN; OXYGENATION; SYNTHESIS;

EID: 0036916881     PISSN: 08861714     EISSN: None     Source Type: Journal    
DOI: 10.1152/nips.01405.2002     Document Type: Article

References (15)

1. Böger RH, Bode-Böger SM, Szuba A, Tsao PS, Chan JR, Tangphao O, Blaschke TF, and Cooke JP. Asymmetric dimethylarginine (ADMA): A novel risk factor for endothelial dysfunction. Its role in hypercholesterolemia. Circulation 98: 1842-1847, 1998.
2. Boucher JL, Moali C, and Tenu JP. Nitric oxide biosynthesis, nitric oxide synthase inhibitors and arginase competition for L-arginine utilization. Cell Mol Life Sci 55: 1015-1028, 1999.
3. Cannon RO III, Schechter AN, Panza JA, Ognibene FP, Pease-Fye ME, Waclawiw MA, Shelhamer JH, and Gladwin MT. Effects of inhaled nitric oxide on regional blood flow are consistent with intravascular nitric oxide delivery. J Clin Invest 108: 279-287, 2001.
4. Garlichs CD, Beyer J, Zhang H, Schmeisser A, Plötze K, Mügge A, Schellong S, and Daniel WG. Decreased plasma concentrations of L-hydroxyarginine as a marker of reduced NO formation in patients with combined cardiovascular risk factors. J Lab Clin Med 135: 419-425, 2000.
5. Gladwin MT, Ognibene FP, Pannell LK, Nichols JS, Pease-Fye ME, Shelhamer JH, and Schechter AN. Relative role of heme nitrosylation and β-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation. Proc Natl Acad Sci USA 97: 9943-9948, 2000.
6. Kelm M. Nitric oxide metabolism and breakdown. Biochim Biophys Acta 1411: 273-289, 1999.
7. Lauer T, Preik M, Rassaf T, Strauer BE, Deussen A, Feelisch M, and Kelm M. Plasma nitrite rather than nitrate reflects regional endothelial nitric oxide synthase activity but lacks intrinsic vasodilator action. Proc Natl Acad Sci USA 98: 12814-12819, 2001.
8. Miyazaki H, Matsuoka H, Cooke JP, Usui M, Ueda S, Okuda S, and Imaizumi T. Endogenous nitric oxide synthase inhibitor. A novel marker of atherosclerosis. Circulation 99: 1141-1146, 1999.
9. Moncada S and Higgs EA. Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J 9: 1319-1330, 1995.
10. Stamler JS, Jaraki O, Osborne J, Simon DI, Keaney J, Vita J, Singel D, Valeri CR, and Loscalzo J. Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci USA 89: 7674-7677, 1992.
11. Stamler JS, Jia L, Eu JP, McMahon TJ, Demchenko IT, Bonaventura J, Gemert K, and Piantadosi CA. Blood flow regulation by 5-nitrosohemoglobin in the physiological oxygen gradient. Science 276: 2034-2037, 1997.
12. Tannenbaum SR, Witter JP, Gatley SJ, and Balish E. Nitrate and nitrite: Origin in humans. Science 205: 1333-1337, 1979.
13. Vallance P, Leone A, Calver A, Collier J, and Moncada S. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339: 572-575, 1992.
14. Wennmalm A, Benthin G, Edlund A, Jungersten L, Kieler-Jensen N, Lundin S, Westfelt UN, Petersson AS, and Waagstein F. Metabolism and excretion of nitric oxide in humans. An experimental and clinical study. Circ Res 73: 1121-1127, 1993.
15. Zoccali C, Bode-Boeger SM, Mallamaci F, Benedetto FA, Tripepi G, Malatino LS, Cataliotti A, Bellanuova I, Fermo I, Frölich JC, and Böger RH. Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: A prospective study. Lancet 358: 2113-2117, 2001.