Cardiovascular and respiratory effects of ketamine infusions in isoflurane-anesthetized dogs before and during noxious stimulation

American Journal of Veterinary Research

Volumn 66, Issue 12, 2005, Pages 2122-2129

  Boscan, Pedro ^a   Pypendop, Bruno H ^a   Solano, Adrian M ^a   Ilkiw, Jan E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOFLURANE; KETAMINE; OXYGEN;

ACID BASE BALANCE; ANESTHETIC RECOVERY; ANIMAL EXPERIMENT; ARTERIAL OXYGEN TENSION; ARTICLE; BALANCED ANESTHESIA; BODY TEMPERATURE; BREATHING; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG INFUSION; DYSPHORIA; HEART INDEX; HEART LEFT VENTRICLE WORK; HEART RIGHT VENTRICLE; HEMODYNAMICS; LUNG VASCULAR RESISTANCE; MINIMUM LUNG ALVEOLUS CONCENTRATION; MYOCLONUS; NOCICEPTIVE STIMULATION; NONHUMAN; OXYGEN CONSUMPTION; OXYGENATION; RESPIRATORY FUNCTION; SALIVATION; STEADY STATE; VASCULAR RESISTANCE; VENOUS OXYGEN TENSION;

ANESTHESIA, INHALATION; ANIMALS; CARDIOVASCULAR SYSTEM; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMODYNAMIC PROCESSES; HYDROGEN-ION CONCENTRATION; INJECTIONS, INTRAVENOUS; ISOFLURANE; KETAMINE; OXYGEN; OXYGEN CONSUMPTION;

ANIMALIA; CANIS FAMILIARIS;

EID: 33645230556     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2005.66.2122     Document Type: Article

References (47)

1. Steffey EP, Howland D Jr. Isoflurane potency in the dog and cat. Am J Vet Res 1977;38:1833-1836.
2. Merin RG, Bernard JM, Doursout ME, et al. Comparison of the effects of isoflurane and desflurane on cardiovascular dynamics and regional blood flow in the chronically instrumented dog. Anesthesiology 1991;74:568-574.
3. Hysing ES, Chelly JE, Doursout MF, et al. Comparative effects of halothane, enflurane, and isoflurane at equihypotensive doses on cardiac performance and coronary and renal blood flows in chronically instrumented dogs. Anesthesiology 1992;76:979-984.
4. Haskins SC, Farver TB, Patz JD. Ketamine in dogs. Am J Vet Res 1985;46:1855-1860.
5. Haskins SC, Farver TB, Patz JD. cardiovascular changes in dogs given diazepam and diazepam-ketamine. Am J Vet Res 1986;47:795-798.
6. Jacobson JD, McGrath CJ, Smith EP. Cardiorespiratory effects of induction and maintenance of anesthesia with ketamine-midazolam combination, with and without prior administration of butorphanol or oxymorphone. Am J Vet Res 1994;55:543-550.
7. Slingsby LS, Waterman-Pearson AE. The post-operative analgesic effects of ketamine after canine ovariohysterectomy - a comparison between pre- or post-operative administration. Res Vet Sci 2000;69:147-152.
8. Pandit SK, Kothary SP, Kumar SM. Low dose intravenous infusion technique with ketamine. Amnesic, analgesic and sedative effects in human volunteers. Anaesthesia 1980;35:669-675.
9. Wagner AE, Walton JA, Hellyer PW, et al. use of low doses of ketamine administered by constant rate infusion as an adjunct for postoperative analgesia in dogs. J Am Vet Med Assoc 2002;221:72-75.
10. Grant IS, Nimmo WS, Clements JA. Pharmacokinetics and analgesic effects of i.m. and oral ketamine. Br J Anaesth 1981;53:805-810.
11. Kararmaz A, Kaya S, Karaman H, et al. Intraoperative intravenous ketamine in combination with epidural analgesia: postoperative analgesia after renal surgery. Anesth Analg 2003;97:1092-1096.
12. Bonanno FG. Ketamine in war/tropical surgery (a final tribute to the racemic mixture). Injury 2002;33:323-327.
13. Weinbroum AA. A single small dose of postoperative ketamine provides rapid and sustained improvement in morphine analgesia in the presence of morphine-resistant pain. Anesth Analg 2003;96:789-795.
14. Pagel PS, Schmeling WT, Kampine JP, et al. Alteration of canine left ventricular diastolic function by intravenous anesthetics in vivo. Ketamine and propofol. Anesthesiology 1992;76:419-425.
15. Kawakubo A, Fujigaki T, Uresino H, et al. comparative effects of etomidate, ketamine, propofol, and fentanyl on myocardial contractility in dogs. J Anesth 1999;13:77-82.
16. Schwieger IM, Szlam F, Hug CC Jr. The pharmacokinetics and pharmacodynamics of ketamine in dogs anesthetized with enflurane. J Pharmacokinet Biopharm 1991;19:145-156.
17. Muir WW III, Wiese AJ, March PA. Effects of morphine, lidocaine, ketamine, and morphine-lidocaine-ketamine drug combination on minimum alveolar concentration in dogs anesthetized with isoflurane. Am J Vet Res 2003;64:1155-1160.
18. Solano A, Pypendop BH, Boscan P, et al. Effect of intravenous ketamine infusion on the minimum alveolar concentration of isoflurane in dogs. Am J Vet Res 2006;in press.
19. Darovic GH. Hemodynamic monitoring: invasive and noninvasive clinical application. 2nd ed. Philadelphia: WB Saunders Co, 1995.
20. Stoelting RK. Pharmacology and physiology in anesthetic practice. 3rd ed. Philadelphia: Lippincott-Raven, 1999.
21. Lumb AB. Nunn's spplied respiratory physiology. 5th ed. Oxford: Butterworth-Heinemann, 2000.
22. Steffey EP, Farver TB, Woliner MJ. cardiopulmonary function during 7 h of constant-dose halothane and methoxyflurane. J Appl Physiol 1987;63:1351-1359.
23. Dunlop CI, Steffey EP, Miller MF, et al. Temporal effects of halothane and isoflurane in laterally recumbent ventilated male horses. Am J Vet Res 1987;48:1250-1255.
24. Thomson IA, Fitch W, campbell D, et al. Effects of ketamine on liver blood flow and hepatic oxygen consumption. Studies in the anaesthetised greyhound. Acta Anaesthesiol Scand 1988;32:10-14.
25. Ebert B, Mikkelsen S, Thorkildsen C, et al. Norketamine, the main metabolite of ketamine, is a non-competitive NMDA receptor antagonist in the rat cortex and spinal cord. Eur J Pharmacol 1997;333:99-104.
26. Leung LY, Baillie TA. Comparative pharmacology in the rat of ketamine and its two principal metabolites, norketamine and (Z)6-hydroxynorketamine. J Med Chem 1986;29:2396-2399.
27. Hirshman CA, McCullough RE, Cohen PJ, et al. Depression of hypoxic ventilatory response by halothane, enflurane and isoflurane in dogs. Br J Anaesth 1977;49:957-963.
28. Hartman JC, Pagel PS, Proctor LT, et al. Influence of desflurane, isoflurane and halothane on regional tissue perfusion in dogs. Can J Anaesth 1992;39:877-887.
29. Newell SM, Ko JC, Ginn PE, et al. Effects of three sedative protocols on glomerular filtration rate in clinically normal dogs. Am J Vet Res 1997;58:446-450.
30. Fass J, Bares R, Hermsdorf V, et al. Effects of intravenous ketamine on gastrointestinal motility in the dog. Intensive Care Med 1995; 21:584-589.
31. Kohrs R, Durieux ME. Ketamine: teaching an old drug new tricks. Anesth Analg 1998;87:1186-1193.
32. Appel E, Dudziak R, Palm D, et al. Sympathoneuronal and sympathoadrenal activation during ketamine anesthesia. Eur J Clin Pharmacol 1979;16:91-95.
33. Kitagawa H, Yamazaki T, Akiyama T, et al. Effects of ketamine on exocytotic and non-exocytotic noradrenaline release. Neurochem Int 2003;42:261-267.
34. Kitagawa H, Yamazaki T, Akiyama T, et al. Effects of ketamine on in vivo cardiac sympathetic nerve endings. J Cardiovasc Pharmacol 2001;38(suppl 1):S39-S42.
35. Kienbaum P, Heuter T, Pavlakovic G, et al. S(+)-ketamine increases muscle sympathetic activity and maintains the neural response to hypotensive challenges in humans. Anesthesiology 2001;94:252-258.
36. Lundy PM, Gverzdys S, Frew R. Ketamine: evidence of tissue specific inhibition of neuronal and extraneuronal catecholamine uptake processes. Can J Physiol Pharmacol 1985;63:298-303.
37. Lundy PM, Lockwood PA, Thompson G, et al. Differential effects of ketamine isomers on neuronal and extraneuronal catecholamine uptake mechanisms. Anesthesiology 1986;64:359-363.
38. White PF, Way WL, Trevor AJ. Ketamine - its pharmacology and therapeutic uses. Anesthesiology 1982;56:119-136.
39. Ogawa K, Tanaka S, Murray PA. Inhibitory effects of etomidate and ketamine on endothelium-dependent relaxation in canine pulmonary artery. Anesthesiology 2001;94:668-677.
40. Nakayama M, Murray PA. Ketamine preserves and propofol potentiates hypoxic pulmonary vasoconstriction compared with the conscious state in chronically instrumented dogs. Anesthesiology 1999;91:760-771.
41. Snijdelaar DG, Cornelisse HB, Schmid RL, et al. A randomised, controlled study of peri-operative low dose s(+)-ketamine in combination with postoperative patient-controlled s(+)-ketamine and morphine after radical prostatectomy. Anaesthesia 2004;59:222-228.
42. Lahtinen P, Kokki H, Hakala T, et al. S(+)-ketamine as an analgesic adjunct reduces opioid consumption after cardiac surgery. Anesth Analg 2004;99:1295-1301.
43. Kawasaki C, Kawasaki I, Ogata M, et al. Ketamine isomers suppress superantigen-induced proinflammatory cytokine production in human whole blood. Can J Anaesth 2001;48:819-823.
44. Kawasaki I, Ogata M, Kawasaki C, et al. Ketamine suppresses proinflammatory cytokine production in human whole blood in vitro. Anesth Analg 1999;89:665-669.
45. Van der Linden P, Gilbart E, Engelman E, et al. Comparison of halothane, isoflurane, alfentanil, and ketamine in experimental septic shock. Anesth Analg 1990;70:608-617.
46. Modig J. Positive effects of ketamine v. metomidate anesthesia on cardiovascular function, oxygen delivery and survival. Studies with a porcine endotoxin model. Acta Chir Scand 1987;153:7-13.
47. Taniguchi T, Takemoto Y, Kanakura H, et al. The dose-related effects of ketamine on mortality and cytokine responses to endotoxin-induced shock in rats. Anesth Analg 2003;97:1769-1772.