Antidepressants and risk of upper gastrointestinal bleeding

Basic and Clinical Pharmacology and Toxicology

Volumn 98, Issue 3, 2006, Pages 304-310

  De Abajo, Francisco J ^a,c   Montero, Dolores ^a   García Rodríguez, Luis A ^b   Madurga, Mariano ^a  

^a Department of Human Use Medicines   (Spain)

^b Spanish Centre for Pharmacoepidemiological Research ^*  (Spain)

^c Division of Pharmacoepidemiology and Pharmacovigilance   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMITRIPTYLINE; AMOXAPINE; ANTICOAGULANT AGENT; ANTIDEPRESSANT AGENT; ANTIULCER AGENT; CITALOPRAM; CLOMIPRAMINE; DESIPRAMINE; DOSULEPIN; ESCITALOPRAM; FLUOXETINE; FLUVOXAMINE; IMIPRAMINE; LOFEPRAMINE; MAPROTILINE; MIANSERIN; NEFAZODONE; NOMIFENSINE; NONSTEROID ANTIINFLAMMATORY AGENT; NORTRIPTYLINE; PAROXETINE; SEROTONIN UPTAKE INHIBITOR; SERTRALINE; STEROID; TRAZODONE; TRICYCLIC ANTIDEPRESSANT AGENT; TRIMIPRAMINE; UNINDEXED DRUG; VENLAFAXINE;

AGE DISTRIBUTION; BINDING AFFINITY; BLEEDING; BLEEDING TIME; BRAIN HEMORRHAGE; CONTUSION; DEPRESSION; DISEASE SEVERITY; DOSE RESPONSE; DRUG BINDING; DRUG EFFECT; DRUG EXPOSURE; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SURVEILLANCE PROGRAM; EPIDEMIOLOGICAL DATA; EPISTAXIS; HIGH RISK PATIENT; HUMAN; LOW DRUG DOSE; NONHUMAN; PETECHIA; PRIORITY JOURNAL; PSYCHIATRIC TREATMENT; RISK FACTOR; SEROTONIN UPTAKE; SHORT SURVEY; THROMBOCYTE; UPPER GASTROINTESTINAL BLEEDING; UROGENITAL TRACT DISEASE;

ADVERSE DRUG REACTION REPORTING SYSTEMS; AGE FACTORS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIDEPRESSIVE AGENTS; BLOOD PLATELETS; DRUG INTERACTIONS; EPIDEMIOLOGIC STUDIES; FLUOXETINE; GASTROINTESTINAL HEMORRHAGE; HUMANS; PAROXETINE; PLATELET AGGREGATION; RISK FACTORS; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SERTRALINE; UPPER GASTROINTESTINAL TRACT;

EID: 33645213533     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2006.pto_303.x     Document Type: Short Survey

References (43)

1. Alderman C. P. C. K. Moritz D. L. Ben-Tovim Abnormal platelet aggregation associated with fluoxetine therapy Ann. Pharmacother. 1992 26 1517 1519
2. Berk M. B. F. Jacobson E. Hurly Fluoxetine and hemostatic function: a pilot study J. Clin. Psychiatry. 1995 56 14 16
3. Calhoun J. W. D. D. Calhoun Prolonged bleeding time in a patient treated with sertraline Amer. J. Psychiatry 1996 153 443
4. Cheeta S. F. Schifano A. Oyfeso L. Webb A. H. Ghodse Antidepressant- related deaths and antidepressant prescriptions in England and Wales, 1998-2000 Brit. J. Psychiatry 2004 184 41 47
5. Dalton S. O. C. Johansen L. Mellemkjær B. Nørgård H. T. Sørensen J. H. Olsen Use of selective serotonin reuptake inhibitors and risk of upper gastrointestinal tract bleeding - a population-based cohort study Arch. Intern. Med. 2003 165 59 64
6. de Abajo F. J. L. A. García Rodríguez D. Montero Association between selective serotonin reuptake inhibitors and upper gastrointestinal bleeding: population based case-control study Brit. Med. J. 1999 319 1106 1109
7. de Abajo F. J. H. Jick L. Derby S. Jick S. Schmitz Intracranial haemorrhage and use of selective serotonin reuptake inhibitors Brit. J. Clin. Pharmacol. 2000 50 43 47
8. Dunn N. R. G. L. Pearce S. A. W. Shakir SSRIs are not more likely than other drugs to cause such bleeding Brit. Med. J. 2000 320 1405 Letter to the Editor
9. García-Rodríguez L. A. S. Pérez Gutthann Use of the UK General Practice Research Database for pharmacoepidemiology Brit. J. Clin. Pharmacol. 1998 45 419 425
10. Gunnell D. D. Ashby Antidepressants and suicide: what is the balance of benefit and harm Brit. Med. J. 2004 329 34 38
11. Hergovich N. M. Aigner H. G. Eichler J. Entlicher C. Drucker B. Jilma Paroxetine decreases platelet serotonin storage and platelet function in human beings Clin. Pharmacol. Therap. 2000 68 435 442
12. Hernández-Díaz S. L. A. García-Rodríguez Overview of epidemiological studies Publisher in the nineties on the association between non-steroidal anti-inflammatory drugs and upper gastrointestinal bleeding/perforation Arch. Intern. Med. 2000 160 2093 2099
13. Humphries J. E. M. S. Wheby S. R. VandenBerg Fluoxetine and the bleeding time Arch. Pathol. Lab. Med. 1990 114 727 728
14. Ishikawa K. S. Shibanoki T. Kubo S. Watabe A. Matsumoto M. Kogure Effects of various tricyclic antidepressants on amine uptake Eur. J. Pharmacol. 1986 120 63 68
15. Javors M. A. J. P. Houston J. L. Tekell S. K. Brannan A. Frazer Reduction of platelet serotonin content in depressed patients treated with either paroxetine or desipramine Int. J. Neuropsychopharmacol. 2000 3 229 235
16. Jureidini J. N. C. Doecke P. R. Mansfield M. M. Haby D. B. Menkes A. L. Tonkin Efficacy and safety of antidepressants for children and adolescents Brit. Med. J. 2004 328 879 883
17. Khon S. L. A. Labbate Venlafaxine and ecchymosis Can. J. Psychiatry 1997 42 91
18. Layton D. D. W. J. Clark G. L. Pearce S. A. W. Shakir Is there an association between selective serotonin reuptake inhibitors and risk of abnormal bleeding? Results from a cohort study based on prescription event monitoring in England Eur. J. Clin. Pharmacol. 2001 57 167 176
19. Lesch K. P. B. L. Wolozin D. L. Murphy R. Reiderer Primary structure of the human platelet serotonin uptake site: identity with the brain serotonin transporter J. Neurochem. 1993 60 2319 2322
20. Leung M. R. Shore Fluvoxamine-associated bleeding Can. J. Psychiatry 1996 41 604 605
21. Lingjærde O. Blood platelets as a model system for studying serotonergic dysfunction and effects of antidepressants Pharmacology & Toxicology 1990 66 Suppl. 3 61 68
22. Markovitz J. H. S. L. Shuster W. S. Chitwood R. S. May L. C. Tolbert Platelet activation in depression and effects of sertraline treatment: an open-label study Amer. J. Psychiatry 2000 157 1006
23. 3H-imipramine binding and serotonin uptake and concentration in major depressive disorder Acta psychiat. scand. 1991 83 125 133
24. Martinez C. S. Rietbrock L. Wise D. Ashby J. Chick J. Moseley S. Evans D. Gunnell Antidepressant treatment and the risk of fatal and non-fatal self harm in first episode depression: nested case-control study Brit. Med. J. 2005 330 389
25. Maurer-Spurej E. Serotonin reuptake inhibitors and cardiovascular diseases: a platelet connection Cell. Mol. Life Sci. 2005 62 159 170
26. Meijer W. E. E. E. R. Heerdink W. A. Nolen R. M. C. Herings H. G. M. Leufkens A. C. G. Egberts Association of risk of abnormal bleeding with degree of serotonin reuptake inhibition by antidepressants Arch. Inter. Med. 2004 164 2367 2370
27. Montero D. R. Coulson F. J. de Abajo G. Martín-Serrano M. Prieto N. Moore Selective serotonin reuptake inhibitors and bleeding disorders. Fourth annual meeting of the European Society of Pharmacovigilance Lisbon 1996
28. Movig K. L. L. M. W. H. E. Janssen J. W. Malefijt P. J. Kabel H. G. M. Leufkens A. C. G. Egberts Relationship of serotoninergic antidepressants and need for blood transfusion in orthopedic surgical patients Arch. Intern. Med. 2003 163 2354 2358
29. Mück-Seler D. M. Jakovjevic Z. Deanovic Effect of antidepressant treatment on platelet 5-HT content and relation to therapeutic outcome in unipolar depressive patients J. Affect. Dis. 1991 23 157 164
30. Narayan M. G. Anderson J. Cellar R. T. Mallison L. H. Price J. C. Nelson Serotonin trnasporter-blocking properties of nefazodone assessed by measurement of platelet serontonin J. Clin. Psychopharmacol. 1998 18 67 71
31. Ottervanger J. P. B. H. C. H. Stricker J. Huls J. N. Weeda Bleeding attributed to the intake of paroxetine Amer. J. Psychiatry 1994 151 781
32. Owens M. J. Selectivity of antidepressants: from the monoamine hypothesis of depression to the SSRI revolution and beyond J. Clin. Psychiatry 2004 65 5 10
33. Pigott T. A. F. L'Hereux C. S. Rubestein S. E. Berstein J. L. Hill D. L. Murphy A double-blind, placebo controlled study of trazodone in patients with obsessive-compulsive disorder J. Clin. Psychopharmacol. 1992 12 156 162
34. Sanz E. J. C. de las Cuevas A. Kiuru A. Bate R. Edwards Selective serotonin reuptake inhibitors in pregnant women and neonatal withdrawal syndrome: a database analysis Lancet 2005 365 482 487
35. Serebruany V. L. P. A. Gurbel C. M. O'Connor Platelet inhibition by sertraline and N-desmethylsertraline: a possible missing link between depression, coronary events and mortality benefits of selective serotonin reuptake inhibitors Pharmacol. Res. 2001 43 453 462
36. Skop B. P. T. M. Brown Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors Psychosomatics 1996 37 12 16
37. Tata L. J. P. J. Fortun R. B. Hubbard L. Smeeth C. J. Hawkey C. J. P. Smith H. J. Whitaker C. P. Farrington T. R. Card J. West Does concurrent prescription of selective serotonin reuptake inhibitors and non-steroidal anti-inflammatory drugs substantially increase the risk of upper gastrointestinal bleeding? Aliment. Pharmacol. Therap. 2005 22 175 181
38. Tatsumi M. K. Groshan R. D. Blakely E. Richelson Pharmacological profile of antidepressants and related compounds at human monoamine transporters Eur. J. Pharmacol. 1997 340 249 258
39. Uppsala Monitoring Centre Viewpoint Part 2. UMC Uppsala 2005 pag 15 Available on website: http:
40. Van Walraven C. M. M. Mamdami P. S. Wells J. I. Williams Inhibition of serotonin reuptake by antidepressants and upper gastrointestinal bleeding in elderly patients: retrospective cohort study Brit. Med. J. 2001 323 1 6
41. Wagner A. D. Montero B. Martensson B. Siwers M. Asberg Effects of fluoxetine treatment of platelet 3H-imipramine binding, 5-HT uptake and 5-HT content in major depressive disorder J. Affect. Dis. 1990 20 101 113
42. Wessinger S. M. Williams L. Choi L. K. Sharp M. D. Crowell A. Keshavarzian M. P. Jones Increased use of selective serotonin reuptake inhibitors in patients admitted with acute gastrointestinal hemorrhage: preliminary observations Digestive Diseases Week Conference Chicago 2005
43. Yaryura-Tobias J. A. H. Kirschen P. Ninan H. J. Mosberg Fluoxetine and bleeding in obsessive-compulsive disorder Amer. J. Psychiatry 1991 148 949