Serotonin transporter-blocking properties of nefazodone assessed by measurement of platelet serotonin

Journal of Clinical Psychopharmacology

Volumn 18, Issue 1, 1998, Pages 67-71

  Narayan, Meena ^a   Anderson, George ^b   Cellar, Janet ^a   Mallison, Robert T ^a   Price, Lawrence H ^a   Nelson, J Craig ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE DERIVATIVE; FLUOXETINE; NEFAZODONE; PAROXETINE; SEROTONIN 2 ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; SERTRALINE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DEPRESSION; DRUG DETERMINATION; DRUG EFFICACY; FEMALE; HAMILTON SCALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MALE; PRIORITY JOURNAL; SEROTONIN BLOOD LEVEL; SEROTONIN UPTAKE;

ADULT; AGED; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; BLOOD PLATELETS; CARRIER PROTEINS; DEPRESSIVE DISORDER; FEMALE; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; TRIAZOLES;

EID: 0031974546     PISSN: 02710749     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004714-199802000-00011     Document Type: Article

References (22)

1. Taylor D, Carter R, Eison A, Mullins U, Smith H, Torrente J, Wright R, Yocca F. Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug. J Clin Psychiatry 1995; 56[suppl 6]:3-11.
2. Rickels K, Schweizer E, Clary C, Fox I, Weise C. Nefazodone and imipramine in major depression: a placebo controlled trial. Br J Psychiatry 1994;164:802-5.
3. 2 receptor blockade: pharmacological studies of MJ 13754, a nontricyclic antidepressant candidate [abstract]. Soc Neurosci Abstr 1982;8:465.
4. Cusack B, Nelson A, Richelson E. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl) 1994;114:559-65.
5. Eison A, Eison M, Torrente J, Wright R, Yocca F. Nefazodone: preclinical pharmacology of a new antidepressant. Psychopharmacol Bull 1990;26:311-5.
6. Owens M, Ieni J. The serotonergic antidepressant nefazodone inhibits the serotonin transporter: in vivo and ex vivo studies. Life Sci 1995;57:373-80.
7. Hemrick-Luecke S, Snoddy H, Fuller R. Evaluation of nefazodone as a serotonin uptake inhibitor and a serotonin antagonist in vivo. Life Sci 1994;55:479-83.
8. Fuller R, Wong W. Serotonin uptake and serotonin uptake inhibition. Ann N Y Acad Sci 1990;600:68-80.
9. Lesch KP, Wolozin BL, Murphy DL, Reiderer P. Primary structure of the human platelet serotonin uptake site: identity with the serotonin transporter. J Neurochem 1993;60:2319-22.
10. Buus LJ, Lund J, Bechgaard E, Sondergaard I. Inhibition of 5-HT uptake into neurons and platelets in mice treated chronically with chlorimipramine and femoxetine. Psychopharmacology (Berl) 1979;64:149-53.
11. Sarrias M, Artigas F, Martinez E, Gelpi E, Alvarez E, Udina C, Casas M. Decreased plasma serotonin in melancholic patients: a study with clomipramine. Biol Psychiatry 1987;22:1429-38.
12. Wagner A, Montero D, Martensson B, Siwers B, Asberg M. Effects of fluoxetine treatment on platelet 3H-imipramine binding, 5-HT uptake and 5-HT content in major depressive patients. J Affect Disord 1990;20:101-13.
13. Kremer H, Goekoop J, Van Kempen G. Clinical use of the determination of serotonin in whole blood. J Clin Psychopharmacol 1990;10:83-7.
14. Muck-Seler D, Jakovljevic M, Deanovic Z. Effect of antidepressant treatment on platelet 5-HT content and relation to therapeutic outcome in unipolar depressive patients. J Affect Disord 1991;23:157-64.
15. Kenny M, Lenehan T, Lambe R, Brick I, Darragh A, Maulet C. The effect of PK5078, a new serotonin uptake inhibitor, on serotonin levels and uptake in human platelets, following administration to healthy volunteers. Eur J Clin Pharmacol 1983;25:23-8.
16. Da Prada M, Cesura A, Lanuay J, Richards J. Platelets as models for neurons? Experientia 1988;44:115-26.
17. Lingjaerde O. From clomipramine to mianserin: therapeutic relevance of interactions with serotonin uptake and storage, as studied in the blood platelet model. Acta Psychiatr Scand 1985; 1985:10-9.
18. Hamilton M. A rating scale for depression. J Clin Psychopharmacol 1987;23:56-62.
19. Anderson GM. Determination of serotonin in whole blood, platelet rich plasma, platelet poor plasma and plasma ultrafiltrate. Life Sci 1987;40:1063-70.
20. Salazar D, Chaikin P, Swanson B, Raymond R. The effects of nefazodone and fluoxetine on platelet serotonin uptake and whole blood serotonin [abstract]. Am Soc Clin Pharmacol Ther 1994;137.
21. Flament M, Rappoport J, Murphy D, Berg C, Lake R. Biochemical changes during clomipramine treatment of childhood obsessive-compulsive disorder. Arch Gen Psychiatry 1987;44:219-25.
22. Karege F, Widmer J, Bovier P, Gaillard J. Platelet serotonin and plasma tryptophan in depressed patients: effect of drug treatment and clinical outcome. Neuropsychopharmacology 1994;10:207-14.