Evidence for linkage to and association with type 1 diabetes at the 3q21 region in the Finnish population

Genes and Immunity

Volumn 7, Issue 1, 2006, Pages 69-72

  Laine, A P ^a   Turpeinen, H ^a   Veijola, R ^b   Hermann, R ^a   Simell, O ^a   Knip, M ^c,d   Ilonen, J ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d TAMPERE UNIVERSITY HOSPITAL   (Finland)

Author keywords

Finnish population; IDDM9; Linkage study; Multifactorial inheritance; Type 1 diabetes

Indexed keywords

ARTICLE; CHROMOSOME 3Q; FAMILY STUDY; FINLAND; GENE INTERACTION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HETEROZYGOTE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MICROSATELLITE MARKER; PRIORITY JOURNAL; RISK ASSESSMENT; SCORING SYSTEM; VERTICAL TRANSMISSION;

ADOLESCENT; CHROMOSOMES, HUMAN, PAIR 3; DIABETES MELLITUS, TYPE 1; FINLAND; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE (GENETICS); LOD SCORE; MICROSATELLITE REPEATS;

EID: 33645167048     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/sj.gene.6364269     Document Type: Article

References (15)

1. Mein CA, Esposito L, Dunn MG, Johnson GC, Timms AE, Goy JV et al. A search for type 1 diabetes susceptibility genes in families from the United Kingdom. Nat Genet 1998; 19: 297-300.
2. Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature 1994; 371: 130-136.
3. Paterson AD, Petronis A. Sex of affected sibpairs and genetic linkage to type 1 diabetes. Am J Med Genet 1999; 84: 15-19.
4. Laine AP, Nejentsev S, Veijola R, Korpinen E, Sjöroos M, Simell O et al. A linkage study of 12 IDDM susceptibility loci in the Finnish population. Diabetes Metab Res Rev 2004; 20: 144-149.
5. Turpeinen H, Laine AP, Nejentsev S, Sjöroos M, Ilonen J, Simell O et al. CD86 gene polymorphisms: No association with Type I diabetes among Finnish subjects. Diabetologia 2002; 45: 1041-1042.
6. Risch N. Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs. Am J Hum Genet 1990; 46: 242-253.
7. Cornelis F, Faure S, Martinez M, Prud'homme JF, Fritz P, Dib C et al. New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study. Proc Natl Acad Sci USA 1998; 95: 10746-10750.
8. Spielman RS, McGinnis RE, Ewens WJ. Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet 1993; 52: 506-516.
9. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 2003; 25: 115-121.
10. Liu K, Muse SV. PowerMarker: An integrated analysis environment for genetic marker analysis. Bioinformatics 2005; 21: 2128-2129.
11. Scott WK, Pericak-Vance MA, Haines JL. Genetic analysis of complex diseases. Science 1997; 275: 1327.
12. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science 1996; 273: 1516-1517.
13. Kruglyak L, Lander ES. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 1995; 57: 439-454.
14. Cox NJ, Wapelhorst B, Morrison VA, Johnson L, Pinchuk L, Spielman RS et al. Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families. Am J Hum Genet 2001; 69: 820-830.
15. Risch N. Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet 1990; 46: 229-241.