The pharmacokinetics of a single rectal dose of paracetamol (40 mg·kg-1) in children with liver disease

Paediatric Anaesthesia

Volumn 16, Issue 4, 2006, Pages 417-423

  Cormack, C R H ^a   Sudan, S ^a   Addison, R ^a   Keating, J ^a   Sherwood, R A ^a   Ashley, E M C ^a,b  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

Author keywords

Acetaminophen; Children; Chronic liver disease; Paracetamol; Rectal; Suppository

Indexed keywords

ANALGESIC AGENT; PARACETAMOL;

ADOLESCENT; ARTICLE; BLOOD SAMPLING; CHILD; CHRONIC LIVER DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG FORMULATION; FEMALE; GENERAL ANESTHESIA; HUMAN; LIVER DISEASE; MALE; PEDIATRIC SURGERY; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; SINGLE DRUG DOSE; SUPPOSITORY; TIME; VARIANCE;

ACETAMINOPHEN; ADMINISTRATION, RECTAL; ADOLESCENT; ANALGESICS, NON-NARCOTIC; ANESTHESIA, GENERAL; BIOLOGICAL AVAILABILITY; CHILD; CHILD, PRESCHOOL; CHRONIC DISEASE; FEMALE; HUMANS; INTERNATIONAL NORMALIZED RATIO; LIVER DISEASES; LIVER FUNCTION TESTS; MALE;

EID: 33645101500     PISSN: 11555645     EISSN: 14609592     Source Type: Journal    
DOI: 10.1111/j.1460-9592.2005.01789.x     Document Type: Article

References (27)

1. Wolsen PD Galletta G Branden NJ et al. Ibuprofen, acetaminophen and placebo treatment of febrile children Clin Pharmacol Ther 1989 46 9 17
2. Birmingham PK Tobin MJ Henthorn TK et al. Twenty-four hour pharmacokinetics of rectal acetaminophen in children Anesthesiology 1997 87 244 252
3. Rumack BH Aspirin versus acetaminophen: a comparative view Pediatrics 1978 62 943 946
4. Brown RD Kearns GL Wilson JT Integrated pharmacokinetic-pharmacodynamic model for acetaminophen, ibuprofen, and placebo antipyresis in children J Pharmacokinet Biopharm 1998 26 559 579
5. Anderson BJ Woollard GA Holford NH Acetaminophen analgesia in children: placebo effect and pain resolution after tonsillectomy Eur J Clin Pharmacol 2001 57 559 569
6. Andersen B Kanagasundarum S Woollard G Analgesic efficiency of paracetamol in children using tonsillectomy as a pain model Anaesth Intensive Care 1996 24 669 673
7. -1) rectal acetaminophen in children Can J Anaesth 1995 42 982 986
8. Birmingham PK Tobin MJ Fisher DM et al. Initial and subsequent dosing of rectal acetaminophen in children: a twenty-four hour pharmacokinetic study of new dose recommendations Anesthesiology 2001 94 385 389
9. -1 Anaesthesia 2003 58 69 73
10. Anderson BJ Woolard GA Holford NHG Pharmacokinetics of rectal paracetamol after major surgery in children Paediatr Anaesth 1995 5 237 242
11. Hahn TW Henneberg SW Holm-Knudsen RJ et al. Pharmacokinetics of rectal paracetamol after repeated dosing in children Br J Anaesth 2000 85 512 519
12. Dange SV Shah KU Deshpande AS et al. Bioavailability of acetaminophen after rectal administration Indian Pediatr 1987 24 331 332
13. ® Healthcare series of databases Micromedex, Drugdex Drug Evaluation - Acetaminophen. Dosing Information and Pharmacokinetics May 2004
14. James LP Farrar HC Sullivan JE et al. Measurement of acetaminophen- protein adducts in children and adolescents with acetaminophen overdoses J Clin Pharmacol 2001 41 846 851
15. Muldrew KL James LP Coop L et al. Determination of acetaminophen-protein adducts in mouse liver and serum and human serum after hepatotoxic doses of acetaminophen using high-performance liquid chromatography with electrochemical detection Drug Metab Dispos 2002 30 446 451
16. James LP Wilson JT Simar R et al. Evaluation of occult acetaminophen hepatotoxicity in hospitalized children receiving acetaminophen. Pediatric Pharmacology Research Unit Network Clin Pediatr (Phila) 2001 40 243 248
17. Rumack BH Matthew H Acetaminophen poisoning and toxicity Pediatrics 1975 55 871 876
18. Rumack BH Acetaminophen: acute overdose toxicity in children Drug Intell Clin Pharm 1985 19 911 912
19. Bond GR Krenzelok EP Normann SA et al. Acetaminophen ingestion in childhood - cost and relative risk of alternative referral strategies J Toxicol Clin Toxicol 1994 32 513 525
20. Anderson BJ Holford NHG Armishaw JC et al. Predicting concentrations in children presenting with acetaminophen overdose J Pediatr 1999 135 290 295
21. Penna A Buchanan N Paracetamol poisoning in children and hepatotoxicity Br J Clin Pharmacol 1991 32 143 149
22. van der Marel CD Anderson BJ van Lingen RA et al. Paracetamol and metabolite pharmacokinetics in infants Eur J Clin Pharmacol 2003 59 243 251
23. Esteban A Perez-Mateo M Heterogeneity of paracetamol metabolism in Gilbert's syndrome Eur J Drug Metab Pharmacokinet 1999 24 9 13
24. Al-Obaidy SS McKiernan PJ Li Wan Po A et al. Metabolism of paracetamol in children with chronic liver disease Eur J Clin Pharmacol 1996 50 69 76
25. Manyike PT Kharasch ED Kalhorn TF et al. Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation Clin Pharmacol Ther 2000 67 275 282
26. Forrest JAH Adriaenssens P Finlayson NDC et al. Paracetamol metabolism in chronic liver disease Eur J Clin Pharmacol 1979 15 427 431
27. Jorup-Ronstrom C Beerman B Wahlin-Boll E et al. Reduction of paracetamol and aspirin metabolism during viral hepatitis Clin Pharmacokinet 1986 11 250 256