Permeability of 13 different gloves to 13 cytotoxic agents under controlled dynamic conditions

American Journal of Health-System Pharmacy

Volumn 63, Issue 6, 2006, Pages 547-556

  Wallemacq, Pierre E ^a,b,c,g   Capron, Arnaud ^d   Vanbinst, Roger ^d   Boeckmans, Eric ^e   Gillard, Jean ^c   Favier, Bertrand ^f  

^a EurClinChem   (Belgium)

^b University Hospital St Luc (UHSL)   (Belgium)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^d UHSL   (Czech Republic)

^e Ansell Healthcare Europe   (Belgium)

^f CENTRE LÉON BÉRARD   (France)

^g CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Antineoplastic agents; Carmustine; Concentration; Gloves; Latex; Molecular weight; Neoprene; Nitrile rubber; Permeability; Permeation; Polymers; Polyvinyl chloride; Solubility; Thickness

Indexed keywords

CARMUSTINE; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; CYTOTOXIC AGENT; DOCETAXEL; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; IFOSFAMIDE; IRINOTECAN; LATEX; METHOTREXATE; NAVELBINE; NEOPRENE; NITRILE; RUBBER; THIOTEPA; VINYL DERIVATIVE;

ARTICLE; DRUG CONCENTRATION; FREEZE THAWING; GLOVE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPID SOLUBILITY; LIQUID CHROMATOGRAPHY; MOLECULAR WEIGHT; MUTAGEN TESTING; OCCUPATIONAL EXPOSURE; PERMEABILITY; PHARMACIST; PRIORITY JOURNAL; REPRODUCIBILITY; SALMONELLA TYPHIMURIUM; STRETCHING; TANDEM MASS SPECTROMETRY; TENSION; THICKNESS; ULTRAVIOLET RADIATION; VALIDATION PROCESS;

EID: 33645081204     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.2146/ajhp050197     Document Type: Article

References (27)

1. Ensslin AS, Pethran A, Schierl R et al. Urinary platinum in hospital personnel occupationally exposed to platinum-containing antineoplastic drugs. Int Arch Occup Environ Health. 1994; 65:339-42.
2. Evelo CT, Bos RP, Peters JG et al. Urinary cyclophosphamide assay as a method for biological monitoring of occupational exposure to cyclophosphamide. Int Arch Occup Environ Health. 1986; 58:151-5.
3. Sessink PJ, Van de Kerkhof MC, Anzion RB et al. Environmental contamination and assessment of exposure to antineoplastic agents by determination of cyclophosphamide in urine of exposed pharmacy technicians: is skin absorption an important exposure route? Arch Environ Health. 1994; 49:165-9.
4. Sessink PJ, Wittebhorst BC, Anzion RB et al. Exposure of pharmacy technicians to antineoplastic agents: reevaluation after additional protective measures. Arch Environ Health. 1997; 52:240-4.
5. Favier B, Gilles L, Desage M et al. [Analysis of cyclophosphamide in the urine of antineoplastic drugs handlers.] Bull Cancer. 2003; 90:905-9. In French.
6. Favier B, Latour JF, Ardiet C et al. [Compared exposure of nurses to cytotoxic agents before and after training.] Arch Mal Prof. 2002; 63:20-4. In French.
7. Favier B, Rull F, Bertucat H et al. Surface and human contamination with 5 fluorouracil in six hospital pharmacies. J Pharm Clin. 2001; 20:157-62.
8. Sessink PJ, Boer KA, Scheefhals AP et al. Occupational exposure to antineoplastic agents at several departments in a hospital: environmental contamination and excretion of cyclophosphamide and ifosfamide in urine of exposed workers. Int Arch Occup Environ Health. 1992; 64:105-12.
9. McDiarmid M, Egan T. Acute occupational exposure to antineoplastic agents. J Occup Med. 1988; 30:984-7.
10. Ladik CF, Stoehr GP, Maurer MA. Precautionary measures in the preparation of antineoplastics. Am J Hosp Pharm. 1980; 37:1184-6.
11. Sotaniemi EA, Sutinen S, Arranto AJ et al. Liver damage in nurses handling cytotoxic agents. Acta Med Scand. 1983; 214:181-9.
12. Hemminki K, Kyyronen P, Lindbohm ML. Spontaneous abortions and malformations in the offspring of nurses exposed to anaesthetic gases, cytotoxic drugs, and other hazards in hospitals, based on registered information of outcome. J Epidemiol Community Health. 1985; 39:141-7.
13. Harris P, Connor T, Stevens K et al. Cytogenetic assessment of occupational exposure of nurses to antineoplastic agents. J Occup Med Tox. 1992; 1:243-54.
14. International Agency for Research on Cancer. IARC monographs on the evaluation of carcinogenic risks to humans. Some antiviral and antineoplastic drugs, and other pharmaceutical agents. Lyon, France: International Agency for Research on Cancer; 2000.
15. Connor TH, Laidlaw JL, Theiss JC et al. Permeability of latex and polyvinyl chloride gloves to carmustine. Am J Hosp Pharm. 1984; 41:676-9.
16. Connor TH. Permeability testing of glove materials for use with cancer chemotherapy drugs. Oncology. 1995; 52:256-9.
17. Laidlaw JL, Connor TH, Theiss JC et al. Permeability of latex and polyvinyl chloride gloves to 20 antineoplastic drugs. Am J Hosp Pharm. 1984; 41:2618-23.
18. Connor TH. Permeability of nitrile rubber, latex, polyurethane, and neoprene gloves to 18 antineoplastic drugs. Am J Health-Syst Pharm. 1999; 56:2450-3.
19. Singleton LC, Connor TH. An evaluation of the permeability of chemotherapy gloves to three cancer chemotherapy drugs. Oncol Nurs Forum. 1999; 26:1491-6.
20. Dinter-Heidorn H, Carstens G. Comparative study on protective gloves for handling cytotoxic medicines: a model study with carmustine. Pharm Weekbl Sci. 1992; 14:180-4.
21. Klein M, Lambov N, Samev N et al. Permeation of cytotoxic formulations through swatches from selected medical gloves. Am J Health-Syst Pharm. 2003; 60:1006-11.
22. European Standard EN 374-3, protective gloves against chemicals and microorganisms; part 3: determination of resistance to permeation by chemicals. Brussels, Belgium: European Committee for Standardization; 2003.
23. Standard test method for resistance of protective clothing materials to permeation by liquids or gases under conditions of continuous contact. F739-99a. West Conshohocken, PA: ASTM International; 1999.
24. Standard practice for assessment of resistance of medical gloves to permeation by chemotherapy drugs. D6978-05. West Conshohocken, PA: ASTM International; 2005.
25. Standard specification for rubber surgical gloves. D3577-01a. West Conshohocken, PA: ASTM International; 2001.
26. Standard specification for rubber examination gloves. D3578-01a. West Conshohocken, PA: ASTM International; 2001.
27. Wallemacq P, Vanbinst R, Asta S et al. High-throughput liquid chromatography-tandem mass spectrometric analysis of sirolimus in whole blood. Clin Chem Lab Med. 2003; 41:921-5.