Hypertension, obesity and GNB3 gene variants

Clinical and Experimental Pharmacology and Physiology

Volumn 33, Issue 3, 2006, Pages 248-252

  Danoviz, María E ^a   Pereira, Alexandre C ^a   Mill, José G ^b   Krieger, José E ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF ESPÍRITO SANTO   (Brazil)

Author keywords

C825T polymorphism; GNB3; Hypertension; Obesity

Indexed keywords

CHOLESTEROL; GUANINE NUCLEOTIDE BINDING PROTEIN BETA SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN BETA3 SUBUNIT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; G PROTEIN BETA3 SUBUNIT; G-PROTEIN BETA3 SUBUNIT; HETEROTRIMERIC GUANINE NUCLEOTIDE BINDING PROTEIN;

ADULT; AGING; ALLELE; ANALYSIS OF VARIANCE; ARTICLE; BLOOD PRESSURE; BODY MASS; BRAZIL; CARDIOVASCULAR RISK; CHI SQUARE TEST; CHOLESTEROL BLOOD LEVEL; CONFIDENCE INTERVAL; DIABETES MELLITUS; ENVIRONMENT; ETHNOLOGY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; HYPERTENSION; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; OBESITY; PHENOTYPE; POPULATION RESEARCH; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; UNIVARIATE ANALYSIS; URBAN AREA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; GENETICS; MIDDLE AGED; PHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; URBAN POPULATION;

ADULT; ALLELES; BLOOD PRESSURE; BRAZIL; CROSS-SECTIONAL STUDIES; FEMALE; GENE FREQUENCY; GENOTYPE; HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; OBESITY; PHENOTYPE; POLYMORPHISM, GENETIC; RISK FACTORS; URBAN POPULATION; VARIATION (GENETICS);

EID: 33645072731     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2006.04353.x     Document Type: Article

References (31)

1. He J Whelton PK Elevated systolic blood pressure and risk of cardiovascular and renal disease: Overview of evidence from observational epidemiologic studies and randomized controlled trials AmHeart J 1999 138 211 19
2. Kannel WB Elevated systolic blood pressure as a cardiovascular risk factor AmJCardiol 2000 85 251 5
3. Sankaranarayanan K Chakraborty R Boerwinkle EA Ionizing radiation and genetic risks. VI. Chronic multifactorial diseases. A review of epidemiological and genetical aspects of coronary heart disease, essential hypertension and diabetes mellitus RevMutatRes 1999 436 21 57
4. Lifton RP Gharavi AG Geller DS Molecular mechanisms of human hypertension Cell 2001 104 545 56
5. Siffert W Rosskopf D Moritz A et al. Enhanced G protein activation in immortalized lymphoblasts from patients with essential hypertension JClinInvest 1995 96 759 66
6. Pietruck F Moritz A Montemurro M et al. Selectively enhanced cellular signaling by Gi proteins in essential hypertension. Gαi2, Gαi3, Gβ1, and Gβ2 are not mutated CircRes 1996 79 974 83
7. Farfel Z Bourne HR Iiri T The expanding spectrum of G protein diseases NEnglJMed 1999 340 1012 20
8. Siffert W Rosskopf D Siffert G et al. Association of a human G-protein β3 subunit variant with hypertension NatGenet 1998 18 45 8
9. Benjafield AV Jeyasingam CL Nyholt DR Griffiths LR Morris BJ G-protein β3 subunit gene (GNB3) variant in causation of essential hypertension Hypertension 1998 32 1094 7
10. Siffert W G-protein β3 subunit 825T allele and hypertension CurrHypertensRep 2003 5 47 53
11. Siffert W G protein polymorphims in hypertension, atherosclerosis, and diabetes AnnuRevMed 2005 56 17 28
12. Siffert W Forster P Jöckel KH et al. Worldwide ethnic distribution of the G protein β3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and black African individuals JAmSocNephrol 1999 10 1921 30
13. Siffert W Naber C Walla M Ritz E G protein β3 subunit 825T allele and its potential association with obesity in hypertensive subjects JHypertens 1999 17 1095 8
14. Benjafield AV Lin RC Dalziel B Gosby AK Caterson ID Morris BJ G-protein beta3 subunit gene splice variant in obesity and overweight ObesRelatMetabDisord 2004 12 679 83
15. Stefan N Stumvoll M Machicao F Koch M Haring HU Fritsche A C825T polymorphism of the G protein beta3 subunit is associated with obesity but not with insulin sensitivity ObesRes 2004 12 679 83
16. Wascher TC Paulweber B Malaimare L et al. Associations of a human G protein beta3 subunit dimorphism with insulin resistance and carotid atherosclerosis Stroke 2003 34 605 9
17. von Beckerath N Schusterschitz Y Koch W et al. G protein beta3 subunit 825T allele carriage and risk of coronary artery disease Atherosclerosis 2003 167 135 9
18. Naber CK Hüsing J Wolfhard U et al. Interaction of the ACE D allele and the GNB3 825T allele in myocardial infarction Hypertension 2000 36 986 9
19. Hengstenberg C Schunkert H Mayer B et al. Association between a polymorphism in the G protein β3 subunit gene (GNB3) with arterial hypertension but not with myocardial infarction CardiovascRes 2001 49 820 7
20. Poch E Gonzalez D Gomez-Angelats E et al. G-protein beta(3) subunit gene variant and left ventricular hypertrophy in essential hypertension Hypertension 2000 35 214 18
21. Sedlacek K Fischer M Erdmann J et al. Relation of the G protein beta3-subunit polymorphism with left ventricule structure and function Hypertension 2002 40 162 7
22. Rosskopf D Frey U Eckhardt S et al. Interaction of the G protein beta3 subunit T825 allele and the IRS-1 Arg972 variant in type 2 diabetes EurJMedRes 2000 5 484 90
23. Tunstall-Pedoe H for the Who MONICA Project. The World Health Organization MONICA project (monitoring trends and determinants in cardiovascular diseases): A major international collaboration JClinEpidemiol 1988 41 105 14
24. Pereira AC Mota GF Cunha RS Herbenhoff FL Mill JG Krieger JE Angiotensinogen 235T allele 'dosage' is associated with blood pressure phenotypes Hypertension 2003 41 25 30
25. Guidelines Subcommittee. World Health Organization-International Society of Hypertension guidelines for the management of hypertension JHypertens 1999 17 151 83
26. Gauderman WJ Sample size requirements for matched case-control studies of gene-environment interaction StatMed 2002 21 35 50
27. Gauderman WJ Sample size requirements for association studies of gene-gene interaction AmJEpidemiol 2002 155 478 84
28. Gauderman WJ Candidate gene association studies for a quantitative trait, using parent-offspring trios GenetEpidemiol 2003 25 327 38
29. Hall JE The kidney, hypertension, and obesity Hypertension 2003 41 625 33
30. Rahmouni K Correia MLG Haynes WG Mark A Obesity-associated hypertension. New insights into mechanisms Hypertension 2005 45 9 14
31. Dong Y Zhu H Wang X et al. Obesity reveals an association between blood pressure and the G-protein beta3-subunit gene: A study of female dizygotic twins Phamacogenetics 2004 14 419 27