Normal sensitivity to excitotoxicity in a transgenic Huntington's disease rat

Brain Research Bulletin

Volumn 69, Issue 3, 2006, Pages 306-310

  Winkler, C ^a   Gil, J M A C ^b,c   Araujo I M ^b,d   Riess O ^e   Skripuletz, T ^a   Von Horsten S ^a   Petersen A ^b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY OF COIMBRA   (Portugal)

^d UNIVERSITY OF COIMBRA   (Portugal)

^e UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Fluoro Jade; HD animal models; Quinolinic acid

Indexed keywords

GLUTAMIC ACID DERIVATIVE; QUINOLINIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXCITOTOXICITY; HUNTINGTON CHOREA; IMMUNOHISTOCHEMISTRY; NONHUMAN; NUCLEOTIDE REPEAT; PRIORITY JOURNAL; PROMOTER REGION; RAT; TRANSGENIC ANIMAL; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BRAIN; DISEASE MODELS, ANIMAL; HUNTINGTON DISEASE; IMMUNOHISTOCHEMISTRY; NEURONS; NEUROTOXINS; ORGANIC CHEMICALS; PHOSPHOPYRUVATE HYDRATASE; QUINOLINIC ACID; RATS; TIME FACTORS; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 33645054561     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2006.01.003     Document Type: Article

References (18)

1. M.F. Beal, N.W. Kowall, D.W. Ellison, M.F. Mazurek, K.J. Swartz, and J.B. Martin Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid Nature 321 1986 168 171
2. S. Davies, and D.B. Ramsden Huntington's disease Mol. Pathol. 54 2001 409 413
3. M. DiFiglia Excitotoxic injury of the neostriatum: a model for Huntington's disease Trends Neurosci. 13 1990 286 289
4. The Huntington's Disease Collaborative Research Group A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes Cell 72 1993 971 983
5. H.J. Gundersen, T.F. Bendtsen, L. Korbo, N. Marcussen, A. Moller, K. Nielsen, J.R. Nyengaard, B. Pakkenberg, F.B. Sorensen, and A. Vesterby Some new, simple and efficient stereological methods and their use in pathological research and diagnosis Apmis 96 1988 379 394
6. O. Hansson, E. Guatteo, N.B. Mercuri, G. Bernardi, X.J. Li, R.F. Castilho, and P. Brundin Resistance to NMDA toxicity correlates with appearance of nuclear inclusions, behavioural deficits and changes in calcium homeostasis in mice transgenic for exon 1 of the huntington gene Eur. J. Neurosci. 14 2001 1492 1504
7. O. Hansson, A. Peters n, M. Leist, P. Nicotera, R.F. Castilho, and P. Brundin Transgenic mice expressing a Huntington's disease mutation are resistant to quinolinic acid-induced striatal excitotoxicity Proc. Natl. Acad. Sci. U.S.A. 96 1999 8727 8732
8. B.R. Jarabek, R.P. Yasuda, and B.B. Wolfe Regulation of proteins affecting NMDA receptor-induced excitotoxicity in a Huntington's mouse model Brain 127 2004 505 516
9. L. Li, M. Fan, C.D. Icton, N. Chen, B.R. Leavitt, M.R. Hayden, T.H. Murphy, and L.A. Raymond Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease Neurobiol. Aging 24 2003 1113 1121
10. A. Petersen, and P. Brundin Huntington's disease: the mystery unfolds? Int. Rev. Neurobiol. 53 2002 315 339
11. A. Petersen, K. Chase, Z. Puschban, M. DiFiglia, P. Brundin, and N. Aronin Maintenance of susceptibility to neurodegeneration following intrastriatal injections of quinolinic acid in a new transgenic mouse model of Huntington's disease Exp. Neurol. 175 2002 297 300
12. L.C. Schmued, C. Albertson, and W. Slikker Jr. Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration Brain Res. 751 1997 37 46
13. E.J. Slow, R.K. Graham, A.P. Osmand, R.S. Devon, G. Lu, Y. Deng, J. Pearson, K. Vaid, N. Bissada, R. Wetzel, B.R. Leavitt, and M.R. Hayden Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions Proc. Natl. Acad. Sci. U.S.A. 102 2005 11402 11407
14. Y. Sun, A. Savanenin, P.H. Reddy, and Y.F. Liu Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-d-aspartate receptors via post-synaptic density 95 J. Biol. Chem. 276 2001 24713 24718
15. T.S. Tang, H. Tu, E.Y. Chan, A. Maximov, Z. Wang, C.L. Wellington, M.R. Hayden, and I. Bezprozvanny Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1 Neuron 39 2003 227 239
16. S. Von Horsten, I. Schmitt, H.P. Nguyen, C. Holzmann, T. Schmidt, T. Walther, M. Bader, R. Pabst, P. Kobbe, J. Krotova, D. Stiller, A. Kask, A. Vaarmann, S. Rathke-Hartlieb, J.B. Schulz, U. Grasshoff, I. Bauer, A.M. Vieira-Saecker, M. Paul, L. Jones, K.S. Lindenberg, B. Landwehrmeyer, A. Bauer, X.J. Li, and O. Riess Transgenic rat model of Huntington's disease Hum. Mol. Genet. 12 2003 617 624
17. J.P. Vonsattel, and M. DiFiglia Huntington disease J. Neuropathol. Exp. Neurol. 57 1998 369 384
18. M.M. Zeron, O. Hansson, N. Chen, C.L. Wellington, B.R. Leavitt, P. Brundin, M.R. Hayden, and L.A. Raymond Increased sensitivity to N-methyl-d-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease Neuron 33 2002 849 860