Incidence of serum anti-P/Q-type and anti-N-type calcium channel autoantibodies in the Lambert-Eaton myasthenic syndrome

Journal of the Neurological Sciences

Volumn 147, Issue 1, 1997, Pages 35-42

  Motomura, Masakatsu ^a,b   Lang, Bethan ^a   Johnston, Irene ^a   Palace, Jacqueline ^a   Vincent, Angela ^a   Newsom Davis, John ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Autoantibodies; Lambert Eaton myasthenic syndrome (LEMS); Radioimmunoassay; Voltage gated calcium channels (VGCCs)

Indexed keywords

AUTOANTIBODY; BRAIN EXTRACT; CALCIUM CHANNEL; OMEGA CONOTOXIN; RADIOLIGAND;

ADOLESCENT; ADULT; AGED; ANTIBODY BLOOD LEVEL; ARTICLE; CEREBELLUM; CONTROLLED STUDY; EATON LAMBERT SYNDROME; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RADIOIMMUNOASSAY;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; AUTOANTIBODIES; BINDING SITES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CARCINOMA, SMALL CELL; CASE-CONTROL STUDIES; CEREBELLUM; FEMALE; HUMANS; LAMBERT-EATON MYASTHENIC SYNDROME; LUNG NEOPLASMS; MALE; MIDDLE AGED; MOLLUSK VENOMS; OMEGA-CONOTOXINS; PEPTIDES; RABBITS; RADIOLIGAND ASSAY;

EID: 0031579642     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(96)05303-8     Document Type: Article

References (28)

1. Bowersox, S.S., Milijanich, G.P., Sugiura, Y., Nadasdi, L., Hoffman, B.B., Ramachandran, J. and Ko, C.P. (1995) Differential blockade of voltage-sensitive calcium channels at the mouse neuromuscular junction by novel ω-cono peptides and Aga IVA. J. Pharmacol. Exp. Ther., 273: 248-256.
2. Chalk, C.H., Murray, N.M., Newsom-Davis, J., O'Neill, J.H. and Spiro, S.G. (1990) Response of the Lambert-Eaton myasthenic syndrome to treatment of associated small-cell lung carcinoma. Neurology, 40: 1552-1556.
3. De Aizpurua, H.J., Lambert, E.H., Griesmann, G.E., Olivera, B.M. and Lennon, V.A. (1988) Antagonism of voltage-gated calcium channels in small cell carcinomas of patients with and without Lambert-Eaton myasthenic syndrome by autoantibodies omega-conotoxin and adenosine. Cancer Res., 48: 4719-4724.
4. Drachman, D.B., Fishman, P.S., Rothstein, J.D., Motomura, M., Lang, B., Vincent, A. and Mellets, E.D. (1995) Amyotrophic lateral sclerosis: an autoimmune disease? Adv. Neurol., 68: 59-66.
5. Elmqvist, D. and Lambert, E.H. (1968) Detailed analysis of neuromuscular transmission in a patient with the myasthenic syndrome sometimes associated with bronchogenic carcinoma. Mayo Clin. Proc., 43: 689-713.
6. Fukunaga, H., Engel, A.G., Lang, B., Newsom-Davis, J. and Vincent, A. (1983) Passive transfer of Lambert-Eaton myasthenic syndrome with IgG from man to mouse depletes the presynaptic membrane active zones. Proc. Natl. Acad. Sci. USA, 80: 7636-7640.
7. Hong, S.J. and Chang, C.C. (1995) Inhibition of acetylcholine release from mouse motor nerve by a P-type calcium channel blocker, ω-agatoxin IVA. J. Physiol., 482.2: 283-290.
8. Johnston, I., Lang, B., Leys, K. and Newsom-Davis, J. (1994) Heterogeneity of calcium channel autoantibodies detected using a small cell lung cancer line derived from a Lambert-Eaton syndrome patient. Neurology, 44: 334-338.
9. Kim, Y.I. (1986) Passively transferred Lambert-Eaton syndrome in mice receiving purified IgG. Muscle Nerve, 9: 532-530.
10. Lambert, E.H., Eaton, L.M. and Rooke, E.D. (1956) Defect of neuromuscular conduction associated with malignant neoplasma. Am. J. Physiol., 187: 612-613.
11. Lang, B., Newsom-Davis, J., Wray, D., Vincent, A. and Murray N.M.F. (1981) Autoimmune aetiology for myasthenic (Eaton-Lambert) syndrome. Lancet, ii: 224-226.
12. Lang, B., Newsom-Davis, J., Prior, C. and Wray, D. (1983) Antibodies to motor nerve terminals: an electrophysiological study of a human myasthenic syndrome transferred to mouse. J. Physiol., 344: 335-345.
13. Lang, B., Johnston, I., Leys, K., Elrington, G., Marqueze, B., Leveque, C., Martin-Moutot, N., Seagar, M., Hoshino, T., Takahashi, M., Sugimori, M., Cherksey, B.D., Llinas, R. and Newsom-Davis, J. (1993) Autoantibody specificities in Lambert-Eaton myasthenic syndrome. Ann. NY Acad. Sci., 681: 382-393.
14. Lennon, V.A. and Lambert, E.H. (1989) Autoantibodies bind solubilised calcium channel-omega-conotoxin complexes from small cell lung carcinoma: a diagnostic aid for Lambert-Eaton myasthenic syndrome. Mayo Clin. Proc., 64: 1498-1504.
15. Lennon, V.A., Kryzer, T.J., Griesmann, G.E., O'Suilleabhain, P.E., Windebank, A.J., Woppmann, A., Miljanich, G.P. and Lambert, E.H. (1995) Calcium-channel antibodies in the Lambert-Eaton syndrome and other paraneoplastic syndromes. N. Engl. J. Med., 332: 1467-1474.
16. Leys, K., Lang, B., Vincent, A. and Newsom-Davis, J. (1989) Calcium channel autoantibodies in Lambert-Eaton myasthenic syndrome. Lancet, ii: 1107.
17. Leys, K., Lang, B., Johnston, I. and Newsom-Davis, J. (1991) Calcium channel autoantibodies in the Lambert-Eaton myasthenic syndrome. Ann. Neurol., 29: 307-314.
18. Llinas, R., Sugimori, M., Lin, J.-W. and Cherskey, B. (1989) Blocking and isolation of a calcium channel from neurons in mammals and cephalopods utilising a toxin fraction (FTX) from funnel-web spider poison. Proc. Natl. Acad. Sci. USA, 86: 1689-1693.
19. McCann, F.V., Pettengill, O.S., Cole, J.J., Russell, J.A.G. and Sorenson, G.D. (1981) Calcium spike electrogenesis and other electrical activity in continuously cultured small cell carcinoma of the lung. Science, 212: 1155-1157.
20. Mossman, S., Vincent, A. and Newsom-Davis, J. (1986) Myasthenia gravis without acetylcholine-receptor antibody: a distinct disease entity. Lancet, i: 116-118.
21. Motomura, M., Johnston. I., Lang, B.,Vincent, A. and Newsom-Davis, J. (1995) An improved diagnostic assay for Lambert-Eaton myasthenic syndrome. J. Neurol. Neurosurg. Psychiatry, 58: 85-87.
22. O'Neill, J.H., Murray, N.M. and Newsom-Davis, J. (1988) The Lambert-Eaton myasthenic syndrome. A review of 50 cases. Brain, 111: 577-596.
23. 2+ currents blocked by the spider toxin Ω-Aga-IVA. NeuroReport, 5: 333-336.
24. 2+ flux in a human small cell carcinoma line. Nature, 317: 737-739.
25. Sher, E., Canal, N., Piccolo, G., Gotti, C., Scoppetta, C., Evoli, A. and Clementi, F. (1989) Specificity of calcium channel autoantibodies in Lambert-Eaton myasthenic syndrome. Lancet, ii: 640-643.
26. Tsien, R.W., Lipscombe, D., Madison, D.V., Bley, K.R. and Fox, A.P. (1988) Multiple types of neuronal calcium channels and their selective modulation. Trends Neurosci., 11: 431-438.
27. Waterman, S.A., Lang, B. and Newsom-Davis, J. (1996) Lambert-Eaton myasthenic syndrome autoantibodies inhibit neurotransmission from postganglionic sympathetic neurons by blocking voltage-gated calcium channels. Neurology, 46: A223-A224.
28. 2+ Channels in supporting hippocampal synaptic transmission. Science, 264: 107-111.