Hypoxic inhibition of human myometrial contractions in vitro: Implications for the regulation of parturition

European Journal of Clinical Investigation

Volumn 36, Issue 2, 2006, Pages 133-140

  Bugg, G J ^a,b   Riley, M J ^a   Johnston, T A ^a   Baker, P N ^a   Taggart, M J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b QUEEN S MEDICAL CENTRE   (United Kingdom)

Author keywords

Dysfunctional labour; Human myometrium; Hypoxia

Indexed keywords

CARBACHOL; CARBON DIOXIDE; OXYTOCIN; PROSTAGLANDIN; SODIUM CHLORIDE;

ADULT; ARTICLE; CESAREAN SECTION; CHILDBIRTH; CONTROLLED STUDY; ELECTIVE SURGERY; FEMALE; HUMAN; HUMAN TISSUE; HYPOXIA; HYSTERECTOMY; LABOR; MYOMETRIUM; PHYSIOLOGY; PREGNANCY; PRIORITY JOURNAL; STIMULATION; UTERUS BIOPSY; UTERUS CONTRACTION;

ADULT; ANOXIA; CARBACHOL; CESAREAN SECTION; CHOLINERGIC AGONISTS; DINOPROST; FEMALE; HUMANS; HYSTERECTOMY; MIDDLE AGED; OXYGEN; OXYTOCICS; OXYTOCIN; PARTURITION; PREGNANCY; TISSUE CULTURE TECHNIQUES; UTERINE CONTRACTION;

EID: 33645049309     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2006.01600.x     Document Type: Article

References (25)

1. Borell U Fernstrom I Ohlson L Wiqvist N The influence of uterine contractions on the utero-placental blood flow at term Am J Obstet Gynecol 1964 93 44 8
2. Brotnaek V Hendrick CH Yoshida T Changes in uterine blood flow during uterine contractions Am J Obstet Gynecol 1969 103 1108 16
3. Peebles DM Spencer JAD Edwards AD Wyatt JS Reynolds EO Cope M et al. Relation between frequency of uterine contractions and human fetal cerebral oxygen saturation studied during labour by near infrared spectroscopy Br J Obstet Gynaecol 1994 101 44 8
4. Gudmundsson HL Olofsson P Uterine artery blood flow velocity waveforms during uterine contractions Ultrasound Obstet Gynecol 2003 22 578 85
5. Larcombe-McDouall J Buttell N Harrison N Wray S In vivo pH and metabolite changes during a single contraction in rat uterine smooth muscle J Physiol 1999 518 783 90
6. Larcombe-McDouall JB Harrison N Wray S The in vivo relationship between blood flow, contractions, pH and metabolites in the rat uterus Plugers Arch 1996 435 810 7
7. Marshall JM Miller MD Effects of metabolic inhibitors on the rat uterus and on its response to oxytocin Am J Physiol 1964 206 437 42
8. 2+, phosphorylation of myosin regulatory light chain and force in rat smooth muscle J Physiol 1997 499 485 96
9. Phoenix J Wray S Changes in frequency and force production of the human myometrium with alteration of pH and metabolism J Reprod Ferti 1993 97 507 12
10. Monir-Bishty E Pierce SJ Kupittayanant S Shmygol A Wray S The effects of metabolic inhibition on intracellular calcium and contractility of human myometrium Br J Obstet Gynecol 2003 110 1050 6
11. Quenby SM Pierce SJ Brigham S Wray S Dysfunctional labour and myometrial lactic acidosis Obstet Gynecol 2004 103 718 23
12. Bugg GJ Stanley E Baker PN Taggart MJ Johnston TA Outcomes of labours augmented with oxytocin Eur J Obstet Gynecol 2006 124 37 41
13. Thomas J Paranjothy S National Sentinel Caesarean Section Audit Report Royal College of Obstetricians and Gynaecologists Clinical Effectiveness Support Unit RCOG Press 2001
14. Lydon Rochelle M Holt VL Martin DP Easterling TR Association between method of delivery and maternal re-hospitalisation JAMA 2000 283 2411 6
15. Chaim W Bashiri A Bar-David J Shoham-Vardi I Mazor M Prevalence and clinical significance of postpartum endometritis and wound infection Infect Dis Obstet Gynecol 2000 8 77 82
16. Hall MH Why Mothers Die 1997-91, 2001
17. Bugg GJ Baker PN Taggart MJ Altered length-dependent contractile activation of isolated human myometria with gestation J Soc Gynecol Invest 2002 9 No. 1 Suppl. 250 A
18. Fuchs AR Fuchs F Husslein P Soloff MS Oxytocin receptors in the human uterus during pregnancy and parturition Am J Obstet Gynecol 1984 150 734 41
19. Bossmar T Akerlund M Fantoni G Szamatowicz J Melin P Maggi M Receptors for and myometrial responses to oxytocin and vasopressin in preterm and term human pregnancy: effects of oxytocin antagonist atosiban Am J Obstet Gynecol 1994 171 1634 42
20. Taggart MJ Wray S Hypoxia and smooth muscle function: key regulatory events during metabolic stress J Physiol 1998 509 315 25
21. Earley L Wray S The effect of hypoxia on force produced by agonists and depolarization and arising spontaneously in the rat uterus J Reprod Fertil 1993 99 539 44
22. Somlyo AP Somlyo AV Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II J Physiol 2000 522 177 85
23. 2+-independent hypoxic vasorelaxation in porcine coronary artery J Physiol 2005 563 839 46
24. Robinson C Schumann R Zhang P Young RC Oxytocin-induced desensitization of the oxytocin receptor Am J Obstet Gynecol 2003 188 497 502
25. Cummiskey KC Gall SA Dawood MY Pulsatile administration of oxytocin for augmentation of labor Obstet Gynecol 1989 74 869 72