Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria

Journal of Periodontal Research

Volumn 41, Issue 1, 2006, Pages 10-14

  Lee, Ju Youn ^a   Yi, Ni Na ^a   Kim, Ueon Suk ^a   Choi, Jeoung Soon ^a   Kim, Sung Jo ^a   Choi, Jeom Il ^a  

^a Pusan National University   (South Korea)

Author keywords

Experimental periodontitis; Heat shook protein; Periodontal vaccine; Porphyromomas gingivalis

Indexed keywords

BACTERIAL VACCINE; CHAPERONIN; IMMUNOGLOBULIN G;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ANIMAL; ARTICLE; BACTERIAL INFECTION; FUSOBACTERIUM NUCLEATUM; GRAM NEGATIVE INFECTION; IMMUNIZATION; IMMUNOLOGY; MICROBIOLOGY; OSTEOLYSIS; PORPHYROMONAS GINGIVALIS; PREVOTELLA INTERMEDIA; RAT; SPRAGUE DAWLEY RAT; TREPONEMA DENTICOLA;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ACTINOBACILLUS INFECTIONS; ALVEOLAR BONE LOSS; ANIMALS; BACTERIAL VACCINES; BACTEROIDACEAE INFECTIONS; BACTEROIDES INFECTIONS; CHAPERONIN 60; FUSOBACTERIUM INFECTIONS; FUSOBACTERIUM NUCLEATUM; GRAM-NEGATIVE BACTERIAL INFECTIONS; GROEL PROTEIN; IMMUNIZATION; IMMUNOGLOBULIN G; PORPHYROMONAS GINGIVALIS; PREVOTELLA INTERMEDIA; RATS; RATS, SPRAGUE-DAWLEY; TREPONEMA DENTICOLA; TREPONEMAL INFECTIONS;

EID: 33645048219     PISSN: 00223484     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0765.2005.00832.x     Document Type: Article

References (21)

1. Klausen B, Evans RT, Ramamurthy NS et al. Periodontal bone level and gingival proteinase activity in gnotobiotic rats immunized with Bacteroides gingivalis. Oral Microbiol Immunnl 1991;6:193-201.
2. Genco CA, Kapczynski DR, Cutler CW, Arko RJ, Arnold RR. Influence of immunization on Porphyromonas gingivalis colonization and invasion in the mouse chamber model. Infect Immun 1992;60:1447-1454.
3. Choi JI, Schifferle RE, Yoshimura F, Kim BW. Capsular polysaccharide-fimbrial protein conjugate vaccine protects against Porphyromonas gingivalis infection in SCID mice reconstituted with human peripheral blood lymphocytes. Infect Immun 1998:66:391-393.
4. Rajapakse PS, O'Brien-Simpson NM, Slakeski N, Hoffman B, Reynolds EC. Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against bone loss in the rat periodontitis model. Infect Immun 2002;70:2480-2486.
5. DeCarlo AA, Huang Y, Collyer CA, Langley DB, Katz J. Feasibility of an HA2 domain-based periodontitis vaccine. Infect Immun 2003;71:562-566.
6. Klausen B. Microbiological and immunological aspects of experimental periodontal disease in rats: a review article. J Periodontol 1991:62:59-73.
7. Page RC. The humoral response in patients with periodontitis: Effects of treatment and prospects for a vaccine. Campend Contin Educ Dent Suppl 1994;18:S666-S671.
8. Dzink JL, Socransky SS, Haffajee AD. The predominant cultivable microbiota of active and inactive lesions of destructive periodontal diseases. J Clin Periodontol 1988;15:316-323.
9. Podmore M, Ebersole JL, Kinane DF. Immunodominant antigens in periodontal disease: a real or illusive concept? Crit Rev Oral Biol Med 2001;12:179-185.
10. Hinode D, Nakamura R, Grenier D, Mayrand D. Cross-reactivity of specific antibodies directed to heat shock proteins from periodontopathogenic bacteria and of human origin. Oral Microbiol Immunol 1998;13:55-58.
11. Choi JI, Choi KS, Yi NN, Kim US, Choi JS, Kim SJ. Recognition and phagocytosis of multiple periodontopathogenic bacteria by anti-Porphyromonas gingivalis heat-shock protein 60 antisera. Oral Microbiol Immunol 2005;20:51-55.
12. Maeda H, Miyamoto M, Hongyo H, Nagai A, Kurihara H, Murayama Y. Heat shock protein 60 (GroEL) from Porphyromonas gingivalis: Molecular cloning and sequence analysis of its gene and purification of the recombinant protein. FEMS Microbiol Lett 1994;119:129-136.
13. Choi JI, Chung SW, Rang HS, Rhim BY, Kim SJ, Kim SJ. Establishment of Porphyromonas gingivalis heat-shock-protein-specific T-cell lines from atherosclerosis patients. J Dent Res 2002;81:344-348.
14. Chung SW, Kang HS, Park HR, Kim SJ, Kim SJ, Choi JI. Immune responses to heat shock protein in Porphyromonas gingivalis-infected periodontitis and atherosclerosis patients. J Periodont Res 2003;38:388-393.
15. Goncharoff P, Figurski DH, Stevens RH, Fine DH. Identification of Actinobacillus actinomycetemcomitans: polymerase chain reaction amplification of lktA-specific sequences. Oral Microbiol Immunol 1993;8:105-110.
16. Fouad AF, Barry J, Caimano M et al. PCR-based identification of bacteria associated with endodontic infections. J Clin Microbiol 2002;40:3223-3231.
17. Gmür R, Thurnheer T, Guggenheim B, Dominant cross-reactive antibodies generated during the response to a variety of oral bacterial species detect phosphorylcholine. J Dent Res 1999;78:77-85.
18. Laine ML, Appelmelk BJ, van Winkelhoff AJ. Prevalence and distribution of six capsular serotypes of Porphyromonas gingivalis in periodontitis patients. J Dent Res 1997;76:1840-1844.
19. Choi JI, Kang HS, Park YM, Kim SJ, Kim US. Identification of T-cell epitopes of Porphyromonas gingivalis heat-shock-protein 60 in periodontitis. Oral Microbiol Immunol 2004;19:1-5.
20. Ando T, Kato T, Ishihara K, Ogiuchi H, Okuda K. Heat shock proteins in human periodontal disease process. Microbiol Immunol 1995;39:321-327.
21. Yamazaki K, Ohsawa Y, Tabeta K et al. Accumulation of human heat shock protein 60-reactive T cells in the gingival tissues of periodontitis patients. Infect Immun 2002;70:2492-2501.