Recognition and phagocytosis of multiple periodontopathogenic bacteria by anti-Porphyromonas gingivalis heat-shock protein 60 antisera

Oral Microbiology and Immunology

Volumn 20, Issue 1, 2005, Pages 51-55

  Choi, Jeom Il ^a   Choi, K S ^a   Yi, N N ^a   Kim, U S ^a   Choi, J S ^a   Kim, S J ^a  

^a Pusan National University   (South Korea)

Author keywords

Heat shock protein; Periodontal disease; Porphyromonas gingivalis; Vaccine

Indexed keywords

ANTISERUM; BACTERIAL PROTEIN; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 60 ANTISERUM; IMMUNOGLOBULIN G ANTIBODY; UNCLASSIFIED DRUG; VACCINE;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; CROSS REACTION; FUSOBACTERIUM NUCLEATUM; MOLECULAR RECOGNITION; MOUSE; MOUTH FLORA; NONHUMAN; OPSONIZATION; PERIODONTAL DISEASE; PERIODONTITIS; PHAGOCYTOSIS; PORPHYROMONAS GINGIVALIS; PREVOTELLA INTERMEDIA; STRAIN DIFFERENCE; TANNERELLA FORSYTHENSIS; TREPONEMA DENTICOLA; VACCINATION;

ANIMALS; ANTIBODY SPECIFICITY; BACTERIAL VACCINES; BLOTTING, WESTERN; CHAPERONIN 60; CROSS REACTIONS; DRUG EVALUATION, PRECLINICAL; IMMUNE SERA; MICE; PERIODONTAL DISEASES; PORPHYROMONAS GINGIVALIS;

EID: 12444289443     PISSN: 09020055     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-302X.2005.00182.x     Document Type: Article

References (18)

1. Ando T, Kato T, Ishihara K, Ogiuchi H, Okuda K. Heat shock proteins in human periodontal disease process. Microbiol Immunol 1995: 39: 321-327.
2. Choi JI, Schifferle RE, Yoshimura F, Kim BW. Capsular polysaccharide-fimbrial protein conjugate vaccine protects against Porphyromonas gingivalis infection in SCID mice reconstituted with human peripheral blood lymphocytes. Infect Immun 1998: 66: 391-393.
3. Choi JI, Chung SW, Kang HS, Rhim BY, Kim SJ, Kim SJ. Establishment of Porphyromonas gingivalis heat-shock-protein-specific T-cell lines from atherosclerosis patients. J Dent Res 2002: 81: 344-348.
4. Choi JI, Kang HS, Park YM, Kim SJ, Kim US. Identification of T-cell epitopes of Porphyromonas gingivalis heat-shock-protein 60 in periodontitis. Oral Microbiol Immunol 2004: 19: 1-5.
5. Choi JI, Yi NN, Kim US, Choi JS, Kim SJ. Porphyromonas gingivalis heat shock protein vaccine reduces the alveolar bone loss induced by multiple periodontopathogenic bacteria. J Dent Res 2004: 83: in press.
6. Dzink JL, Socransky SS, Haffajee AD. The predominant cultivable microbiota of active and inactive lesions of destructive periodontal diseases. J Clin Periodontol 1988: 15: 316-323.
7. Gmür R, Thurnheer T, Guggenheim B. Dominant cross-reactive antibodies generated during the response to a variety of oral bacterial species detect phosphorylcholine. J Dent Res 1999: 78: 77-85.
8. Hinode D, Nakamura R, Grenier D, Mayrand D. Cross-reactivity of specific antibodies directed to heat shock proteins from periodontopathogenic bacteria and of human origin. Oral Microbiol Immunol 1998: 13: 55-58.
9. Kaufmann SHE, Schoel B, van Embden JDA, Koga T, Wand-Wurttenberger A, Munk ME, Steinhoff U. Heat-shock protein 60: Implications for pathogenesis of and protection against bacterial infections. Immunol Rev 1991: 121: 67-90.
10. Klausen B. Microbiological and immunological aspects of experimental periodontal disease in rats: a review article. J Periodontol 1991: 62: 59-73.
11. Klausen B, Evans RT, Ramamurthy NS, Golub LM, Sfintescu C, Lee JY, et al. Periodontal bone level and gingival proteianse activity in gnotobiotic rats immunized with Bacteroides gingivalis. Oral Microbiol Immunol 1991: 6: 193-201.
12. Laine ML, Appelmelk BJ, van Winkelhoff AJ. Prevalence and distribution of six capsular serotypes of Porphyromonas gingivalis in periodontitis patients. J Dent Res 1997: 76: 1840-1844.
13. Maeda H, Miyamoto M, Hongyo H, Nagai A, Kurihara H, Murayama Y. Heat shock protein 60 (GroEL) from Porphyromonas gingivalis. Molecular cloning and sequence analysis of its gene and purification of the recombinant protein. FEMS Microbiol Lett 1994: 119: 129-136.
14. Page RC. The humoral response in patients with periodontitis: Effects of treatment and prospects for a vaccine. Compend Contin Educ Dent Suppl 1994: 18: S666-S671.
15. Podmore M, Ebersole JL, Kinane DF. Immunodominant antigens in periodontal disease: a real or illusive concept? Crit Rev Oral Biol Med 2001: 12: 179-185.
16. Rajapakse PS, O'Brien-Simpson NM, Slakeski N, Hoffman B, Reynolds EC. Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against bone loss in the rat periodontitis model. Infect Immun 2002: 70: 2480-2486.
17. Shinnick TM. Heat shock proteins as antigens of bacterial and parasitic pathogens. Curr Top Microbiol Immunol 1991: 167: 145-160.
18. Yamazaki K, Ohsawa Y, Tabeta K, Ito H, Ueki K, Oda T, et al. Accumulation of human heat shock protein 60-reactive T cells in the gingival tissues of periodontitis patients. Infect Immun 2002: 70: 2492-2501.