Progress and hindrances in tuberculosis vaccine development

Lancet

Volumn 367, Issue 9514, 2006, Pages 947-949

  Doherty, T Mark ^a   Rook, Graham ^b  

^a STATENS SERUM INSTITUT   (Denmark)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BCG VACCINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4; PROTEIN AG85B; PROTEIN ESAT6; PROTEIN MTB72F; RECOMBINANT PROTEIN; SRL 172; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

BACTERIAL VIRULENCE; BCG VACCINATION; CD25+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL TRIAL; DRUG EFFICACY; HUMAN; LUNG TUBERCULOSIS; MEMORY CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SHORT SURVEY; T LYMPHOCYTE; TH1 CELL; TH2 CELL; TUBERCULOSIS;

EID: 33645008275     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(06)68389-X     Document Type: Review

References (11)

1. P Andersen, TM Doherty The success and failure of BCG: implications for a novel tuberculosis vaccine Nat Rev Microbiol 3 2005 656 662
2. TM Doherty, P Andersen Vaccines for tuberculosis: novel concepts and recent progress Clin Micro Rev 18 2005 687 702
3. GAW Rook, K Dheda, A Zumla Immune responses to TB in developing countries: implications for new vaccines Nat Rev Immmunol 5 2005 661 667
4. A Demissie, M Abebe, A Aseffa Healthy individuals that control a latent infection with M tuberculosis express high levels of Th-1 cytokines and the IL-4 antagonist IL-4δ2 J Immunol 172 2004 6938 6943
5. K Dheda, J-S Chang, RA Breen In vivo and in vitro studies of a novel cytokine, interleukin-4delta2, in pulmonary tuberculosis Am J Respir Crit Care Med 172 2005 501 508
6. C Manca, MB Reed, S Freeman Differential monocyte activation underlies strain-specific Mycobacterium tuberculosis pathogenesis Infect Immun 72 2004 5511 5514
7. JO Olobo, M Geletu, A Demissie Circulating TNF-alpha, TGF-beta, and IL-10 in tuberculosis patients and healthy contacts Scand J Immunol 53 2001 85 91
8. Y Belkaid, BT Rouse Natural regulatory T cells in infectious disease Nat Immunol 6 2005 353 360
9. V Guyot-Revol, JA Innes, S Hackforth, T Hinks, A Lalvani Regulatory T Cells are expanded in blood and disease sites in tuberculosis patients Am J Respir Crit Care Med 2005 Published online Dec 9, 2005
10. M Walther, JE Tongren, L Andrews Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection Immunity 23 2005 287 296
11. F Gerosa, C Nisii, S Righetti CD4(+) T cell clones producing both interferon-gamma and interleukin-10 predominate in bronchoalveolar lavages of active pulmonary tuberculosis patients Clin Immunol Immunopathol 92 1999 224 234